A5011885090- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Whipple's Disease and Interleukins
- Obstructive Sleep Apnea Research
- Pediatric health and respiratory diseases
- Pneumonia and Respiratory Infections
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Psoriasis: Treatment and Pathogenesis
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Airway Management and Intubation Techniques
- Mobile Health and mHealth Applications
- Sinusitis and nasal conditions
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Stroke Rehabilitation and Recovery
- Cardiovascular and exercise physiology
- Sleep and related disorders
- Technology Use by Older Adults
- Electrical and Bioimpedance Tomography
- Cytokine Signaling Pathways and Interactions
- Inflammation biomarkers and pathways
Sahlgrenska University Hospital
2017-2025
University of Gothenburg
2009-2025
National Academy of Medicine
2024
Swedish Asthma and Allergy Association
2022
Respiratory Clinical Trials
2016
Centrallasarettet Växjö
1975
Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term therapy has been recommended to be used 24 day, more burdensome regimen.
Abstract Background Breathlessness is common in the population and can be related to a range of medical conditions. We aimed evaluate burden breathlessness different conditions middle-aged population. Methods Cross-sectional analysis population-based Swedish CArdioPulmonary bioImage Study adults aged 50–64 years. (modified Medical Research Council [mMRC] ≥ 2) was evaluated relation self-reported symptoms, stress, depression; physician-diagnosed conditions; measured body mass index (BMI),...
Purpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). However, combined data on CRS, function, lower airway symptoms, cigarette smoking from the general population are lacking. The current study investigates relationships between CRS airflow limitation (CAL), symptoms COPD in a middle-aged of ever-smokers never-smokers. Patients Methods: All subjects Swedish CArdioPulmonary bioImage Study (SCAPIS) were included. Subjects underwent...
Rationale: Postbronchodilator spirometry is used for the diagnosis of chronic obstructive pulmonary disease. However, prebronchodilator reference values are interpretation. Objectives: To compare resulting prevalence rates abnormal and study consequences using pre- or postbronchodilator generated within SCAPIS (Swedish CArdioPulmonary bioImage Study) when interpreting in a general population. Methods: were based on 10,156 1,498 never-smoking, healthy participants, respectively. We studied...
A series of 37 patients with cecal volvulus treated at three different Swedish hospitals during the years 1952–1973 is presented. The symptoms, physical findings and radiologic features are associted factors found operation described their possible role in provoking torsion discussed. In 5 diagnosis did not become clear until autopsy. Thirty-tow were subjected to operation. consisted dteorsion 11 cases, cecopexy 10, cecostomy 3 plus patients. remaining patiens right sided hemioclecotmy. Of...
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory lung with high morbidity and mortality. The IL-36 family are proinflammatory cytokines that known to shape innate immune responses, including those critical bacterial pneumonia. objective of this study was determine whether promote milieu in the lungs long-term smokers without COPD. Concentrations were measured plasma BAL fluid from subjects pilot (
In patient care, demand is growing for digital health tools to enable remote services and enhance involvement. People with chronic conditions often have multiple problems, long-term follow-up recommended meet their needs access appropriate support. A tool previsit preparation could time efficiency guide the conversation during visit toward patient's priorities.This study aims develop a explore potential end user's perceptions, using participatory approach stroke as case example.The was...
There is incomplete mechanistic understanding of the mobilization neutrophils in systemic and local compartment smokers with chronic obstructive pulmonary disease (COPD). In this pilot study, we characterized how adhesion molecules CD11b CD62L, surface markers indicative priming, are altered as extravasate, whether density CD62L differs between long-term tobacco (LTS) without COPD compared healthy never-smokers (HNS). Unstimulated blood from LTS (<i>n</i> = 5) 9) displayed lower...
We examined whether systemic cytokine signaling via interleukin (IL)-17 and growth-related oncogene-α (GRO-α) is impaired in smokers with obstructive pulmonary disease including chronic bronchitis (OPD-CB). also how this relates to bacterial colonization the airways of OPD-CB. Currently smoking OPD-CB patients (n=60, corresponding Global initiative for Obstructive Lung Disease [GOLD] stage I-IV) underwent recurrent blood sputum sampling over 60 weeks, during stable conditions at...
Background: The aim of this population-based study was to investigate the risk developing noninfectious rhinitis (NIR) in subjects with chronic obstructive pulmonary disease (COPD). Materials and methods: This is a longitudinal comprising 3,612 randomly selected from Gothenburg, Sweden, aged 25–75 years. Lung function measured at baseline spirometry included answered questionnaire on respiratory symptoms. At follow-up, response rate 87%. NIR defined as symptoms nasal obstruction, secretion,...
Patients with chronic obstructive pulmonary disease (COPD) frequently suffer from bronchitis (CB) and display steroid-resistant inflammation increased sputum neutrophils macrophages. Recently, a causal link between mucus hyper-concentration progression of CB has been suggested. In this study, we have evaluated the steroid sensitivity purified, patient-derived alveolar macrophages used novel mechanistic cross-talk assay to examine how bronchial epithelial cells regulate MUC5B production. We...
Background Coexisting obstructive sleep apnoea (OSA) in patients with COPD, defined as overlap syndrome (OVS), is prevalent and underdiagnosed. Routine assessment of OSA not common practice COPD care. Our study assessed the clinical impact by peripheral arterial tonometry (PAT) patients. Methods 105 (mean age 68.1±9 years, body mass index (BMI) 28.3±6.0 kg·m −2 , 44% males, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I to IV 2%, 40%, 42% 16%, respectively) underwent...
Methods: Over a period of 60 weeks for each subject, blood samples were repeatedly collected from smokers with OPD-CB during clinically stable periods, as well and after exacerbations. Myeloperoxidase (MPO) neutrophil elastase (NE) protein mRNA, growth bacteria in sputum, clinical parameters analyzed. Ten asymptomatic ten never-smokers included controls. Results: We found that, NE concentrations increased the when compared never-smokers. During exacerbations, MPO further OPD-CB, without...
Chronic airflow limitation (CAL) can be defined as fixed ratio of forced expiratory volume in 1 s (FEV1 )/forced vital capacity (FVC) < 0.70 after bronchodilation. It is unclear which the most optimal relation to respiratory morbidity. The aim was investigate what extent different ratios FEV1 /FVC were associated with any symptom. In a cross-sectional general population study, 15,128 adults (50-64 years age), 7,120 never-smokers and 8,008 ever-smokers completed questionnaire performed FVC We...
SUMMARY CD4+ and CD8+ lymphocytes are mobilized in severe chronic obstructive pulmonary disease (COPD) the cytokine interleukin (IL)-16 is believed to be important regulating recruitment activity of lymphocytes. In current study, we examined whether tobacco smoke exerts an impact not only on IL-16 lower airways but also or lymphoid tissue. The concentration protein was measured by enzyme-linked immunosorbent assay (ELISA) concentrated bronchoalveolar lavage fluid (BALF) collected from 33...
Interleukin-16-producing NK cells and T-cells in the blood of tobacco smokers with without COPD Anders Andersson,1,* Carina Malmhäll,2,* Birgitta Houltz,1 Sara Tengvall,1 Margareta Sjöstrand,2 Ingemar Qvarfordt,1 Lindén,3 Apostolos Bossios2 1Respiratory Medicine Allergology, Department Internal Clinical Nutrition, Institute Medicine, Sahlgrenska Academy at University Gothenburg, Sweden; 2Krefting Research Center, 3Unit for Lung Airway Research, Environmental Karolinska...
Abstract There is little information on mucins versus potential regulatory factors in the peripheral airway lumen of long-term smokers with (LTS+) and without (LTS−) chronic obstructive pulmonary disease (COPD). We explored these matters bronchoalveolar lavage (BAL) samples from two study materials, both including LTS+ LTS− a very similar historic exposure to tobacco smoke, healthy non-smokers (HNSs; n=4–20/group). Utilizing slot blot immunodetection processed (filtered centrifuged), as well...
Chronic exposure to tobacco smoke leads an increase in the frequency of infections and number CD8 + CD4 cells as well chemoattractant cytokine IL-16 airways. Here, we investigated whether depletes intracellular protein inhibits de novo production from human airways blood while increasing extracellular oxygen free radicals (OFR) are involved. Intracellular mRNA all was decreased bronchoalveolar lavage (BAL) samples chronic smokers. This also case exposed water-soluble components vitro, which...
Chronic obstructive pulmonary disease (COPD) is associated with colonization by bacterial pathogens and repeated airway infections, leading to exacerbations impaired lung function. The highly glycosylated mucins in the mucus lining airways are an important part of host defense against pathogens. However, accumulation can contribute COPD pathology. Here, we examined whether inflammation glycosylation changes that affect interactions between We isolated from lower samples (n = 4-9) long-term...
Background The diagnosis of chronic obstructive pulmonary disease is based on the presence persistent respiratory symptoms and airflow limitation (CAL). CAL ratio forced expiratory volume in 1 s to vital capacity (FEV :FVC) after bronchodilation, FEV :FVC less than fifth percentile often used as a cut-off for CAL. aim was investigate if increasing percentiles were associated with any symptom (cough phlegm, dyspnoea or wheezing) general population sample never-smokers ever-smokers. Methods In...
Abstract Purpose Chronic obstructive pulmonary disease (COPD) is associated with several co-morbidities and non-infectious rhinitis (NIR) has emerged as a new possible co-morbidity. The primary aim of this study to confirm previously reported association between NIR COPD in multicentre population over time. secondary investigate the course time such an through comparison early- late-onset COPD. Methods This part European Community Respiratory Health Survey (ECRHS). A random adult from 25...
<b>Background:</b><i>Chronic obstructive pulmonary disease (COPD) comprises local and systemic neutrophilic inflammation. Neutrophils contain the intracellular enzymes myeloperoxidase (MPO) neutrophil elastase (NE) these contribute to anti-bacterial activity in host defense. However, it is not known if hypoxia during COPD exacerbations associated with resulting MPO NE release.</i> <b>Aims:</b><i>To determine <b>Methods:</b><i>Blood samples were harvested (ie. blood gas partial oxygen...