A5000661913- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Pituitary Gland Disorders and Treatments
- Cardiac Arrhythmias and Treatments
- Obstructive Sleep Apnea Research
- Psychosomatic Disorders and Their Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Hip and Femur Fractures
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cardiovascular Disease and Adiposity
- Migraine and Headache Studies
- Ophthalmology and Eye Disorders
- Cardiac Health and Mental Health
- Cerebrovascular and Carotid Artery Diseases
- Genetic Associations and Epidemiology
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Health disparities and outcomes
Lund University
2016-2025
Skåne University Hospital
2016-2025
Malmö University
2017-2024
Hammersmith Hospital
2017
GTx (United States)
2012
Abstract Aims Diagnostic criteria for ambulatory blood pressure monitoring (ABPM) in patients with suspected reflex syncope are lacking. The study hypothesis was that have a higher prevalence of systolic (SBP) drops on ABPM. Methods and results ABPM data from controls, matched by average 24 h SBP, age, sex, hypertension were compared. Patients constitutional hypotension, orthostatic predominant cardioinhibition during carotid sinus massage or prolonged electrocardiogram competing causes...
Recent studies indicate that the urokinase system could have an important role in atherogenesis and plaque rupture. The relationships among soluble plasminogen activator receptor (suPAR), carotid plaque, incidence of ischemic stroke coronary artery disease (CAD) events were studied a prospective cohort.Occurrence plasma levels suPAR assessed 5166 men women, aged 45 to 68 years, participating Malmö Diet Cancer study. Incidences CAD monitored during mean follow-up 15 years.Subjects with had...
We hypothesized that cardiovascular physiology differs in reflex syncope patients compared with the general population, predisposing such individuals to vasovagal reflex.
Abstract Aims Unexplained syncope is an important clinical challenge. The influence of age at first on the final diagnosis not well studied. Methods and results Consecutive head-up tilt patients (n = 1928) evaluated for unexplained were stratified into groups <30, 30–59, ≥60 years based syncope. Clinical characteristics analysed in relation to investigation. had a bimodal distribution with peaks 15 70 years. Prodromes (64 vs. 26%, P < 0.001) vasovagal (VVS, 59 19%, more common...
Abstract Background Postural orthostatic tachycardia syndrome (POTS) is a common cardiovascular autonomic disorder characterized by excessive heart rate (HR) increase on standing and symptoms of intolerance, posing significant limitations functional capacity. No objective tool exists to classify symptom burden in POTS. Methods We conducted case–control study 62 POTS patients 50 healthy controls compare between groups using the newly developed, self‐rating, 12‐item, Malmö Score (MAPS; 0–10...
Background Ambulatory blood pressure (BP) monitoring has long been used to monitor BP in hypertension and lately emerged as a useful tool detect hypotensive susceptibility reflex syncope. However, hemodynamic characteristics syncope have not sufficiently explored. The present study investigated the differences between ambulatory profiles associated with normal population. Methods Results This is an observational comparing data from 50 patients 100 controls without syncope, age- sex-matched...
The contribution of diastolic blood pressure measurement to the diagnosis classical orthostatic hypotension is not known. We aimed explore prevalence isolated systolic and components in patients with syncope intolerance. A total 1520 aged >15 years suspected and/or symptoms intolerance were investigated a tertiary center using tilt-table testing continuous non-invasive monitoring. Classical was defined as decline ≥20 mmHg ≥10 at 3 min tilt test. upright <90 its overlap also assessed. One...
Background Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive heart rate increase on standing and intolerance. Previous data indicate autoimmune involvement. We studied serum activity against G protein–coupled receptors in relation to symptoms patients with POTS controls using a commercial cell‐based assay. Methods Results Forty‐eight (aged 28.6±10.5 years; 44 women) 25 healthy individuals 30.7±8.6 21 were included. The 10‐item Orthostatic Hypotension...
Background: Postural orthostatic tachycardia syndrome (POTS) is a disorder of intolerance that primarily affects women childbearing age. The underlying pathophysiology POTS not fully understood, but it has been suggested autoimmunity may play role. aim this study was to compare concentrations autoantibodies cardiovascular G protein–coupled receptors between patients with and healthy controls. Methods: Sera were collected from 116 (91% female; medium age, 29 years) 81 controls (84% 27...
Abstract Background Orthostatic hypotension (OH) is an important differential diagnosis in unexplained syncope. Neurogenic OH (nOH) has been postulated to differ from non-neurogenic (non-nOH), yet pathophysiological differences are largely unexplored. We aimed investigate etiology and tilt table test (TTT)-induced hemodynamic responses symptomatic patients. Methods performed a retrospective study analyzing patients referred for syncope or highly orthostatic intolerance with TTT-verified...
Background Preserved ratio impaired spirometry (PRISm) is a pattern of interest regarding incident airflow obstruction and higher mortality risk. We applied proteomic approach to gain more insight into the biological mechanisms associated with PRISm. Methods From population-based Swedish CArdioPulmonary bioImage Study (SCAPIS), participants in Main (n=4835) Pilot (n=1054) studies, were included as discovery replication cohorts. Lower limit normal (LLN) post-bronchodilator FEV 1 , FVC /FVC...
Background: Orthostatic hypotension (OH) is a major sign of cardiovascular autonomic failure leading to orthostatic intolerance and syncope. traditionally divided into classical OH (cOH) delayed (dOH), but the differences between two variants are not well-studied. We performed systematic clinical neuroendocrine characterization patients in tertiary syncope unit. Methods: Among 2,167 consecutive (1,316 women, 60.7%; age, 52.6 ± 21.0 years) evaluated for unexplained severe with standardized...
Abstract Postural orthostatic tachycardia syndrome (POTS) is a cardiovascular autonomic disorder characterized by excessive heart rate increase on standing, leading to debilitating symptoms with limited therapeutic possibilities. Proteomics large-scale study of proteins that enables systematic unbiased view disease and health, allowing stratification patients based their protein background. The aim the present was determine plasma biomarkers POTS reveal proteomic pathways differentially...
Abstract Purpose Arterial stiffness is independently associated with orthostatic hypotension in older individuals. The relationship between blood pressure adaptation and aortic has not been thoroughly examined a younger population. We investigated the adaptations, central hemodynamics, cohort of predominantly middle-aged adults. Methods analyzed an observational, population-based study 5259 individuals living Malmö, Sweden. related hemodynamics assessed by carotid–femoral pulse wave velocity...
Rationale: Postbronchodilator spirometry is used for the diagnosis of chronic obstructive pulmonary disease. However, prebronchodilator reference values are interpretation. Objectives: To compare resulting prevalence rates abnormal and study consequences using pre- or postbronchodilator generated within SCAPIS (Swedish CArdioPulmonary bioImage Study) when interpreting in a general population. Methods: were based on 10,156 1,498 never-smoking, healthy participants, respectively. We studied...
Abstract Postural Orthostatic Tachycardia Syndrome (POTS) reflects an autonomic dysfunction, which can occur as a complication to COVID-19. Our aim was examine gastrointestinal symptoms and gut microbiota composition in patients with POTS post-acute COVID-19 syndrome (PACS), compared controls. ( n = 27), PACS 32) controls 39) delivered fecal samples completed 4-day food diary, irritable bowel syndrome-severity scoring system (IBS-SSS), visual analog scale for IBS (VAS-IBS). A total of 98 DNA...
We applied near-infrared-spectroscopy (NIRS) to measure absolute frontal cerebral tissue oxygen saturation (SctO2) during head-up tilt test (HUT) in patients investigated for unexplained syncope.Synchronized non-invasive beat-to-beat haemodynamic monitoring, ECG, SctO2 (NIRS; normal range: 60-80%), and peripheral (left hand, SpO2) were HUT a random sample of with syncope. Tracings 54 (mean-age: 55 ± 19 years, 39% male) negative HUT, vasovagal syncope (VVS), or orthostatic hypotension (OH)...
Abstract Aims Syncope is a common condition with many possible causes, ranging from benign to life-threatening aetiologies. Establishing diagnosis can be difficult, and specialized syncope units, using cardiovascular autonomic tests (CATs), including head-up tilt test, increase the diagnostic yield. However, up one-fifth of examined patients have inconclusive CAT results. The aim present study was investigate predictive value history, clinical findings for unexplained after characterize...
Chromosome 9p21 variants are associated with cardiovascular disease (CVD) but not any of its known risk markers. However, recent studies have suggested that the variation is modified by a prudent dietary pattern and smoking. We tested if increased CVD single nucleotide polymorphism rs4977574 intakes vegetables, fruits, alcohol, or wine, interacts environmental factors on Multivariable Cox regression analyses were performed in 23,949 individuals from population-based prospective Malmö Diet...
Abstract Background Genetic variation in the cluster on chromosome 15, encoding nicotinic acetylcholine receptor subunits ( CHRNA 5‐ 3‐ CHRNB 4 ), has shown strong associations with tobacco consumption and an additional risk increase smoking‐related diseases such as chronic obstructive pulmonary disease COPD peripheral artery lung cancer. Objectives To test whether rs1051730 (C/T), a tag for multiple variants 3 cluster, is associated change of mortality morbidity Malmö Diet Cancer study,...
Abstract Studies evaluating the relationship between platelet indices and cardiovascular (CV) outcomes yielded conflicting results. We assessed incidence of adverse events according to baseline quintiles in prospective cohort Malmö Diet Cancer Study. A total 30,314 individuals (age 57 ± 8 years) were followed for a median 16 years (468,490 person-years). Outcome measures included all-cause death, CV myocardial infarction (MI), ischemic stroke. The fifth quintile count (> 274.6 × 109/L)...
Background Vasovagal reflex is the most common form of syncope, but pathophysiological mechanisms that initiate are not well understood. We aimed to study supine and early orthostatic levels neurohormones involved in control circulatory homeostasis relation onset tilt‐induced vasovagal syncope (VVS). Methods Results A total 827 patients who were investigated for unexplained with head‐up tilt test (HUT) optional nitroglycerin provocation (Italian protocol) had blood samples collected while...
Aims The CHA 2 DS VASc score is used to evaluate the risk of thromboembolic events in patients with non-valvular atrial fibrillation. We assessed prognostic yield for new-onset fibrillation, cardiovascular morbidity and mortality a non-atrial fibrillation population. Methods analysed population-based cohort 22,179 middle-aged individuals ( n = 3542) without 18,367) history fibrillation; we grouped population into five strata (0–1–2–3–≥4), compared major adverse cerebro-cardiovascular...