A5042783947- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Coronary Interventions and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Elasticity and Material Modeling
- Pulmonary Hypertension Research and Treatments
- Atomic and Subatomic Physics Research
- Liver Disease Diagnosis and Treatment
- Congenital Heart Disease Studies
- Heart Rate Variability and Autonomic Control
- MRI in cancer diagnosis
- Advanced X-ray and CT Imaging
- Cardiovascular and exercise physiology
- Aortic aneurysm repair treatments
- Liver Disease and Transplantation
Linköping University
2016-2025
Linköping University Hospital
2001-2023
Örebro County Council
2012-2014
University of California, San Francisco
2010
Stanford University
2007-2009
Palo Alto Institute
2007
The beating heart is the generator of blood flow through cardiovascular system. Within heart's own chambers, normal complex patterns can be disturbed by diseases. Methods for quantification intra-cardiac flow, with its 4D (3D+time) nature, are lacking. We sought to develop and validate a novel semi-automatic analysis approach that integrates morphological data. In six healthy subjects three patients dilated cardiomyopathy, three-directional, three-dimensional cine phase-contrast magnetic...
Patients with mild heart failure (HF) who are clinically compensated may have normal left ventricular (LV) stroke volume (SV). Despite this, altered intra-ventricular flow patterns been recognized in these subjects. We hypothesized that, compared LVs, myopathic LVs would demonstrate a smaller proportion of inflow passing directly to ejection and diminished the end-diastolic preservation kinetic energy (KE). In 10 patients dilated cardiomyopathy (DCM) (49 ± 14 years, six females) healthy...
Quantification of the longitudinal- and transverse relaxation time in myocardium has shown to provide important information cardiac diagnostics. Methods for mapping generally demand a long breath hold measure either T1 or T2 single 2D slice. In this paper we present evaluate novel method 3D interleaved whole left ventricular within 15 heartbeats. The 3D-QALAS (3D-quantification using an Look-Locker acquisition sequence with preparation pulse) is based on spoiled Turbo Field Echo inversion...
Right ventricular (RV) function is a powerful prognostic indicator in many forms of heart disease, but its assessment remains challenging and inexact. RV dysfunction may alter the normal patterns blood flow, those have been incompletely characterized. We hypothesized that, based on anatomic differences, proportions energetics flow components would differ from identified left ventricle (LV) that portion inflow passing directly to outflow (Direct Flow) be prepared for effective systolic...
Intracardiac blood flow patterns are potentially important to cardiac pumping efficiency. However, these complex remain incompletely characterized both in health and disease. We hypothesized that normal left ventricular (LV) would preferentially optimize a portion of the end-diastolic volume (LVEDV) for effective rapid systolic ejection by virtue location near motion towards LV outflow tract (LVOT). Three-dimensional cine velocity morphological data were acquired 12 healthy persons 1 patient...
Abstract Subject-specific parameters in lumped hemodynamic models of the cardiovascular system can be estimated using data from experimental measurements, but parameter estimation may hampered by variability input data. In this study, we investigate influence inter-sequence, intra-observer, and inter-observer on subject-specific model a previously developed approach for model-based analysis 4D Flow MRI acquisitions cuff pressure measurements. The investigated describe left ventricular...
Purpose To assess turbulent kinetic energy (TKE) within the left ventricle (LV) of healthy subjects using novel 4D flow magnetic resonance imaging (MRI) methods and to compare TKE values those from a limited group patients with spectrum dilated cardiomyopathy (DCM). Materials Methods morphological MRI data were acquired in 11 9 different degrees diastolic dysfunction. LV was calculated at each timeframe. At peak early (E) late (A) filling, compared transmitral velocity, diameter, mitral...
Turbulent blood flow is implicated in the pathogenesis of several aortic diseases but extent and degree turbulent normal aorta unknown. We aimed to quantify turbulece assess whether age impacts turbulence. 22 young males (23.7 ± 3.0 y.o.) 20 old (70.9 3.5 were examined using four dimensional magnetic resonance imaging (4D Flow MRI) kinetic energy (TKE), a measure intensity turbulence, aorta. All healthy subjects developed aorta, with total TKE 3 – 19 mJ. The overall turbulence entire was...
Aims 4D flow magnetic resonance imaging (MRI) allows quantitative assessment of left ventricular (LV) function according to characteristics the dynamic in chamber. Marked abnormalities components’ volume and kinetic energy (KE) have previously been demonstrated moderately dilated depressed LV’s compared healthy subjects. We hypothesized that these flow-based measures would detect even subtle LV dysfunction remodeling. Methods Results acquired morphological MRI data from 26 patients with...
We hypothesized that the direction of global left ventricular (LV) hemodynamic forces during diastolic filling are concordant with main flow axes in normal LVs, but this pattern would be altered dilated and dysfunctional LVs. Therefore, we aimed to assess LV a group healthy subjects compare them results from patients cardiomyopathy (DCM). Ten 10 DCM were enrolled. Morphological short- (SAx) long-axis (LAx) images 4D MRI data acquired at 1.5T. The pressure gradients computed using...
Abstract Background Breathlessness is common in the population and can be related to a range of medical conditions. We aimed evaluate burden breathlessness different conditions middle-aged population. Methods Cross-sectional analysis population-based Swedish CArdioPulmonary bioImage Study adults aged 50–64 years. (modified Medical Research Council [mMRC] ≥ 2) was evaluated relation self-reported symptoms, stress, depression; physician-diagnosed conditions; measured body mass index (BMI),...
Flow volume quantification in the great thoracic vessels is used assessment of several cardiovascular diseases. Clinically, it often based on semi-automatic segmentation a vessel throughout cardiac cycle 2D cine phase-contrast Cardiovascular Magnetic Resonance (CMR) images. Three-dimensional (3D), time-resolved CMR with three-directional velocity encoding (4D flow CMR) permits net volumes and patterns retrospectively at any location 3D volume. However, analysis these datasets can be...
Background: Cardiac remodeling, after a myocardial insult, often causes progression to heart failure. The relationship between alterations in left ventricular blood flow, including kinetic energy (KE), and remodeling is uncertain. We hypothesized that increasing derangements flow would relate (1) conventional cardiac markers, (2) increased levels of biochemical (3) altered energetics, (4) worsening patient symptoms functional capacity. Methods Thirty-four dilated cardiomyopathy patients, 30...
Purpose To investigate four-dimensional (4D) flow CT for the assessment of intracardiac blood patterns as compared with 4D MRI. Materials and Methods This prospective study acquired coronary angiography MRI data between February December 2016 in a cohort 12 participants (age range, 36–74 years; mean age, 57 seven men [age years] five women 52–73 64 years]). Flow simulations based solely on CT-derived cardiac anatomy were assessed together measurements. patterns, rates, stroke volume, kinetic...
Blood flow simulations are making their way into the clinic, and much attention is given to estimation of fractional reserve in coronary arteries. Intracardiac blood also show promising results, here field expected depend on pulmonary venous (PV) rates. In absence vivo measurements, distribution from individual PVs often unknown typically assumed. Here, we performed intracardiac based time-resolved computed tomography three patients, investigated effect PV rate left atrium ventricle. A...
Background Segmenting the whole heart over cardiac cycle in 4D flow MRI is a challenging and time‐consuming process, as there considerable motion limited contrast between blood tissue. Purpose To develop evaluate deep learning‐based segmentation method to automatically segment chambers great thoracic vessels from MRI. Study Type Retrospective. Subjects A total of 205 subjects, including 40 healthy volunteers 165 patients with variety disorders were included. Data randomly divided into...
This study aimed to assess the validity of International Fitness Scale (IFIS) for evaluating cardiorespiratory fitness compared 6-minute walk test (criterion validity) and examine their associations with cardiometabolic body composition outcomes (construct in adults type 2 diabetes mellitus (T2DM). A cross-sectional analysis was conducted on 282 T2DM (mean age 63.6 +- 8.1 years, 37.9% women). Self-reported assessed using IFIS, including overall scores. Objective test. Associations (i.e.,...
Background: Arterial mechanics are crucial to cardiovascular functionality. The pressure–strain elastic modulus often delineates mechanical properties. Emerging methods use non-linear continuum and non-convex minimization identify tissue-specific parameters in vivo. Reliability of these methods, particularly their accuracy representing the vivo stress state, is a significant concern. This study aims compare predicted state collagen-attributed load-bearing fraction with from silico...
Obstructive sleep apnoea is a common yet frequently underdiagnosed condition in patients with type 2 diabetes, particularly primary care. Early detection important, as untreated may contribute to worsened metabolic control and increased cardiovascular risk. This study evaluated 164 diabetes found that 75% had obstructive apnoea, 31% requiring treatment for moderate severe cases. Predicting which medical indicated (i.e., OSA) proved challenging, typical clinical symptoms most other readily...
Abstract Imaging-defined atherosclerosis represents an intermediate phenotype of atherosclerotic cardiovascular disease (ASCVD). Genome-wide association studies (GWAS) on directly measured coronary plaques using computed tomography angiography (CCTA) are scarce. In the so far largest population-based cohort with CCTA data, we performed a GWAS plaque burden as determined by segment involvement score (SIS) in 24,811 European individuals. We identified 20 significant independent genetic markers...