Paolo Montuschi
A5021762566- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Chemical Sensor Technologies
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- IL-33, ST2, and ILC Pathways
- Respiratory Support and Mechanisms
- Air Quality and Health Impacts
- Metabolomics and Mass Spectrometry Studies
- Gas Sensing Nanomaterials and Sensors
- Neuropeptides and Animal Physiology
- Nitric Oxide and Endothelin Effects
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug-Induced Adverse Reactions
- Antioxidant Activity and Oxidative Stress
- Delphi Technique in Research
- Eicosanoids and Hypertension Pharmacology
- Cystic Fibrosis Research Advances
- Pediatric health and respiratory diseases
- Free Radicals and Antioxidants
- Insect Pheromone Research and Control
- Neuroscience of respiration and sleep
Università Cattolica del Sacro Cuore
2016-2025
Imperial College London
2001-2025
Agostino Gemelli University Polyclinic
2014-2024
University of the Sacred Heart
2003-2022
Tameside and Glossop Integrated Care NHS Foundation Trust
2022
University of Florence
2022
University of Trieste
2022
Azienda Sanitaria Universitaria Integrata di Trieste
2022
Humanitas University
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020
Oxidative stress has an important role in the pathogenesis of asthma. 8-Isoprostane is a prostaglandin (PG)-F2–like compound belonging to F2 isoprostane class that produced vivo by free radical-catalyzed peroxidation arachidonic acid. biomarker oxidative stress, and its concentration increased bronchoalveolar lavage fluid patients with interstitial lung diseases. We measured 8-isoprostane concentrations exhaled breath condensate healthy subjects mild (steroid naive, n = 12), moderate...
Most of the studies linking chronic obstructive pulmonary disease (COPD) with oxidative stress are in vitro, using invasive techniques, or measuring systemic stress. The aim this study was to quantify lungs patients COPD and healthy smokers, as reflected by 8-isoprostane concentrations breath condensate. This is a noninvasive method collect airway secretions. 8-Isoprostane prostaglandin-F(2alpha) isomer that formed vivo free radical-catalyzed peroxidation arachidonic acid. We also studied...
Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables exhaled breath condensate (EBC) and other measurements. For EBC for FeNO, official recommendations standardised procedures are more than 10 years old there is none VOCs particles. The aim this document to provide technical standards sample collection analytic approaches highlight future research priorities field. new developments advances technology have been evaluated current...
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective improving understanding asthma disease mechanisms using systems biology approach. This cross-sectional assessment adults severe asthma, mild/moderate healthy controls from countries consisted analyses patient-reported outcomes, lung function, blood airway inflammatory measurements. Patients (nonsmokers, n=311; smokers/ex-smokers, n=110) had more...
bacKgrOund: Air pollution is associated with respiratory symptoms, lung function decrements, and hospitalizations.However, there little information about the influence of air on injury.Objective: In this study we investigated acute effects pulmonary airway oxidative stress inflammation in asthmatic children.MethOds: We studied 182 children asthma, 9-14 years age, for 4 weeks.Daily ambient concentrations sulfur dioxide, nitrogen ozone, particulate matter ≤ 2.5 µm aerodynamic diameter (PM )...
BackgroundAlthough several studies link high levels of IL-6 and soluble receptor (sIL-6R) to asthma severity decreased lung function, the role trans-signaling (IL-6TS) in asthmatic patients is unclear.ObjectiveWe sought explore association between epithelial IL-6TS pathway activation molecular clinical phenotypes patients.MethodsAn gene signature obtained from air-liquid interface cultures human bronchial cells stimulated with sIL-6R was used stratify transcriptomic data (Unbiased Biomarkers...
The role of eicosanoids, including leukotrienes (LTs) and prostaglandins (PGs), in chronic obstructive pulmonary disease (COPD) is uncertain. aim this study was to investigate whether eicosanoids are measurable exhaled breath condensate (EBC), a non-invasive method collecting airway secretions, patients with stable mild moderate COPD, show possible differences their concentrations compared control subjects.LTB(4), LTE(4), PGE(2), PGD(2)-methoxime, PGF(2alpha), thromboxane B(2) (TxB(2)) were...
Oxidative stress contributes to the pathophysiology of interstitial lung diseases, such as cryptogenic fibrosing alveolitis (CFA), associated with systemic sclerosis (FASSc) and sarcoidosis. F2-isoprostanes are a series prostaglandin (PG) F2-like compounds produced in vivo independent cyclooxygenase, products radical-catalyzed lipid peroxidation. Measurement concentrations has proved be valuable assessing oxidative vivo. The aim this study was measure 8-epi-PGF2 α concentrations, one most...
bacKgrOund: Air pollution is associated with respiratory symptoms, lung function decrements, and hospitalizations.However, there little information about the influence of air on injury.Objective: In this study we investigated acute effects pulmonary airway oxidative stress inflammation in asthmatic children.MethOds: We studied 182 children asthma, 9-14 years age, for 4 weeks.Daily ambient concentrations sulfur dioxide, nitrogen ozone, particulate matter ≤ 2.5 µm aerodynamic diameter (PM )...
Cystic fibrosis is characterised by oxidative stress in the airways. Isoprostanes are prostaglandin isomers formed free radical catalysed peroxidation of arachidonic acid. 8-Isoprostane increased interstitial lung diseases, asthma, chronic obstructive pulmonary disease, and adult respiratory distress syndrome. Exhaled nitric oxide (NO) carbon monoxide (CO) biomarkers inflammation airways, respectively.Concentrations 8-isoprostane breath condensate 10 normal subjects 19 patients with stable...
Nitrosothiols (RS-NOs) are formed by interaction of nitric oxide (NO) with glutathione and may limit the detrimental effect NO. Because NO generation is increased in airway inflammation, we have measured RS-NOs exhaled breath condensate patients asthma, cystic fibrosis, or chronic obstructive pulmonary disease (COPD). We also nitrite (NO2 −) same subjects. were detectable all higher subjects severe asthma (0.81 ± 0.06 μ M) when compared normal control (0.11 0.02 M, p < 0.01) mild (0.08 0.01...
The pathogenesis of aspirin-induced asthma (AIA) has not yet been clearly elucidated, although eicosanoid metabolites appear to play an important role. We hypothesized that levels eicosanoids in exhaled air condensate are abnormal patients with AIA and they change receiving steroid therapy. measured cysteinyl-leukotrienes (cys-LTs), prostaglandin E2 (PGE2), leukotriene B4 (LTB4), also 8-isoprostane as a marker oxidative stress, by enzyme immunoassay breath from (17 naive; mean age, 41 ± 23...
<h3>Background</h3> Metabolomics could provide new insights into the pathophysiology of cystic fibrosis (CF) by identifying profiles endogenous metabolites. <h3>Objectives</h3> To investigate whether metabolomics exhaled breath condensate discriminate between patients with unstable CF, stable CF and healthy subjects, selected metabolites were responsible for between-group differences. <h3>Methods</h3> Twenty-nine 24 31 subjects (age 9–24 years) participated in a cross-sectional study. was...