A5081783610- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Neuropeptides and Animal Physiology
- Inhalation and Respiratory Drug Delivery
- Food Allergy and Anaphylaxis Research
- Pediatric health and respiratory diseases
- Receptor Mechanisms and Signaling
- Occupational exposure and asthma
- Mast cells and histamine
- Advanced Chemical Sensor Technologies
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- Heart Rate Variability and Autonomic Control
- Cystic Fibrosis Research Advances
- Delphi Technique in Research
- Eicosanoids and Hypertension Pharmacology
- Eosinophilic Esophagitis
- Hydrogen's biological and therapeutic effects
- Health, psychology, and well-being
- Renal function and acid-base balance
Uppsala University
2015-2024
Uppsala University Hospital
2008-2019
Health and Human Development (2HD) Research Network
2019
Odense University Hospital
2017
Women's & Children's Health Research Institute
2015
Aerocrine (Sweden)
2014
Karolinska Institutet
1999-2008
Centre for Research and Development
2008
Swedish University of Agricultural Sciences
2001-2008
Örebro University
2003
The presence of nitric oxide (NO) in the exhaled air humans has recently been described. We wanted to assess at what level NO originates normal airways, and determine whether airway inflammation induces changes levels NO. Exhaled was continuously measured by chemiluminescence technique during tidal breathing through nose or mouth, with a detection limit 1 part per billion (ppb). Twelve control subjects were compared eight patients mild atopic asthma rhinitis caused occupational allergen. In...
High values (800-6000 parts per billion) of nitric oxide (NO) in expelled air from the stomach were shown humans by chemiluminescence technique. These NO more than 100 times higher those found orally exhaled air. Intragastric production is probably non-enzymatic, requiring an acidic environment, as was reduced 95% after pretreatment with proton pump inhibitor omeprazole. Furthermore, large amounts formed vitro lettuce and saliva when placed hydrogen chloride (pH < 2). In conclusion, are...
The exact origin of nitric oxide (NO) in exhaled air is not known. We wanted to further investigate at what site NO produced and determine whether children with Kartagener's syndrome exhibited altered levels NO. was measured by chemiluminescence technique sampled directly from the nose normally four (2.5-13 years old) syndrome, 20 healthy children, adults, conscious tracheostomized adults. almost absent (98% reduced) (4 +/- 1 parts per billion (ppb)), compared age-matched controls (221 14...
Measurement of fractional exhaled nitric oxide in air is an exciting innovative technique that gives new insights to the pathophysiology lung disease and asthma particular, with many potential clinical applications. Careful standardisation measurement techniques will facilitate use this paediatric respiratory medicine: Task Force was set up for purpose. Methodologies, all age groups, are already available there abundant questions relating interpretation application waiting be addressed....
The fundamental, yet poorly understood, physiological mechanism known as 'acidic-metabolic' vasodilation, contributes to local blood flow regulation during hypoxia/ischaemia and increased metabolic activity. vasodilator nitric oxide (NO) has been suggested be involved in this event. Besides enzymatic production by NO synthases, a novel for generation of gas vivo was recently described. This involves non-enzymatic reduction inorganic nitrite NO, reaction that takes place predominantly...
Nitric oxide (NO) is present in exhaled air of humans. This NO mostly produced the upper airways, whereas basal excretion lower airways low. Children with Kartagener9s syndrome have an almost total lack nasally derived air, adult asthmatics increased orally air. was measured nasal cavity and 19 healthy children, 36 age matched subjects asthma, eight children cystic fibrosis. levels were similar controls fibrosis, at 4.8 (SD 1.2) v 5.8 (0.8) parts per billion (ppb), but asthmatic who...
Abstract Background Exhaled nitric oxide (NO) measurement has been shown to be a valuable tool in the management of patients with asthma. Up now, most measurements have done stationary, chemiluminescence-based NO analysers, which are not suitable for primary health care setting. A hand-held analyser simplifies would value both specialized and care. In this study, performance new electrochemical device exhaled (NIOX MINO) was compared standard stationary chemiluminescence unit (NIOX). Methods...
Dietary and metabolic nitrate is distributed from the blood to saliva by active uptake in salivary glands, reduced nitrite oral cavity action of certain bacteria. Since it has been reported that nitric oxide may be formed nonenzymatically this study aimed determine whether could influence measurements exhaled NO. Ten healthy subjects fasted overnight ingested 400 mg potassium nitrate, equivalent approximately 200 g spinach. Exhaled NO nasal were regularly measured with a chemiluminescence...
The relationship between nitric oxide in exhaled air, levels of sputum eosinophils, eosinophil cationic protein (ECP) and urinary X (EPX) excretion has not yet been investigated corticosteroid-dependent childhood asthma. Therefore, taking 25 children with stable asthma (mean age 11.2 yrs) treated inhaled corticosteroids nine nonatopic healthy control 12.8 the level NO was measured by means a chemiluminescence analyser before after induction. This conducted as slow vital capacity manoeuvre...
Periostin has been suggested as a novel, phenotype-specific biomarker for asthma driven by type 2 inflammation. However, large studies examining relationships between circulating periostin and patient characteristics are lacking the suitability of in remains unclear.To examine healthy controls subjects with from general population different severity treatment profiles, both without chronic rhinosinusitis (CRS), relation to other biomarkers clinical characteristics.Serum was examined ELISA...
Rationale: New approaches are needed to guide personalized treatment of asthma.Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping.Methods: Urinary prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes were quantified in the U-BIOPRED (Unbiased Biomarkers for Prediction Respiratory Diseases Outcomes) study including 86 adults with mild-to-moderate (MMA), 411 severe (SA), 100 healthy control participants. Validation was performed internally...