Joost Brandsma
A5011380932- Asthma and respiratory diseases
- Microbial Community Ecology and Physiology
- Metabolomics and Mass Spectrometry Studies
- Marine and coastal ecosystems
- IL-33, ST2, and ILC Pathways
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bacteriophages and microbial interactions
- Mass Spectrometry Techniques and Applications
- Methane Hydrates and Related Phenomena
- Sepsis Diagnosis and Treatment
- Marine Bivalve and Aquaculture Studies
- COVID-19 Clinical Research Studies
- Eosinophilic Esophagitis
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Wastewater Treatment and Nitrogen Removal
- Genomics and Phylogenetic Studies
- S100 Proteins and Annexins
- Single-cell and spatial transcriptomics
- Advanced Proteomics Techniques and Applications
- Nosocomial Infections in ICU
- Inflammasome and immune disorders
- Analytical Chemistry and Chromatography
- Digital Imaging for Blood Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
Henry M. Jackson Foundation
2021-2025
University of Southampton
2013-2024
NIHR Southampton Biomedical Research Centre
2018-2024
Karolinska Institutet
2018-2023
National Institute for Health Research
2023
Karolinska University Hospital
2023
Jackson Foundation
2021
Royal Netherlands Institute for Sea Research
2011-2021
Southampton General Hospital
2017-2021
Manchester Academic Health Science Centre
2021
As the lipidomics field continues to advance, self-evaluation within community is critical. Here, we performed an interlaboratory comparison exercise for using Standard Reference Material (SRM) 1950-Metabolites in Frozen Human Plasma, a commercially available reference material. The study comprised 31 diverse laboratories, with each laboratory different workflow. A total of 1,527 unique lipids were measured across all laboratories and consensus location estimates associated uncertainties...
BackgroundAlthough several studies link high levels of IL-6 and soluble receptor (sIL-6R) to asthma severity decreased lung function, the role trans-signaling (IL-6TS) in asthmatic patients is unclear.ObjectiveWe sought explore association between epithelial IL-6TS pathway activation molecular clinical phenotypes patients.MethodsAn gene signature obtained from air-liquid interface cultures human bronchial cells stimulated with sIL-6R was used stratify transcriptomic data (Unbiased Biomarkers...
Upon phosphorus (P) deficiency, marine phytoplankton reduce their requirements for P by replacing membrane phospholipids with alternative non-phosphorus lipids. It was very recently demonstrated that a SAR11 isolate also shares this capability when phosphate starved in culture. Yet, the extent to which process occurs other heterotrophic bacteria and natural environment is unknown. Here, we demonstrate substitution of variety lipids conserved response deficiency among phylogenetically diverse...
Primary ciliary dyskinesia (PCD) is a heterogeneous inherited disorder caused by mutations in approximately 50 cilia-related genes. PCD genotype-phenotype relationships have mostly arisen from small case series because existing statistical approaches to investigating been unsuitable for rare diseases.We applied topological data analysis (TDA) approach investigate PCD. Data separate training and validation cohorts included 396 genetically defined individuals carrying pathogenic variants To...
Abstract Climate change-induced global warming threatens the survival of key ecosystems including shallow water coral reefs. Elevated temperatures can disrupt normal physiological functioning photosynthetic organisms by altering fluidity and permeability chloroplast membranes that is defined regulated their lipid composition. Since habitat-forming reef corals rely on obligatory symbiosis with dinoflagellates family Symbiodiniaceae , heat stress response be expected to strongly influenced...
Rationale: New approaches are needed to guide personalized treatment of asthma.Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping.Methods: Urinary prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes were quantified in the U-BIOPRED (Unbiased Biomarkers for Prediction Respiratory Diseases Outcomes) study including 86 adults with mild-to-moderate (MMA), 411 severe (SA), 100 healthy control participants. Validation was performed internally...
Background: The anti-IgE monoclonal, omalizumab, is widely used for severe asthma. This study aimed to identify biomarkers that predict clinical improvement during one year of omalizumab treatment. Methods: 1-year, open-label, Study Mechanisms action Omalizumab in Severe Asthma (SoMOSA) involving 216 (GINA step 4/5) uncontrolled atopic asthmatics (≥2 exacerbations previous year) on high-dose inhaled corticosteroids, long-acting β-agonists, ± mOCS. It had two phases: 0-16 weeks, assess early...
Anaerobic ammonium oxidation (anammox) is an important process for nitrogen removal in marine pelagic and benthic environments represents a major sink the global cycle. We applied suite of complementary methods detection enumeration anammox activity bacteria sediments Gullmar Fjord, compared results obtained with each technique. (15) N labelling experiments showed that through N2 production was essentially limited to upper 2 cm sediment, where contributed 23-47% total production. The...
Airborne pathogenic transmission from sources to humans is characterised by atmospheric dispersion and influence of environmental conditions on deposition reaerosolisation. We applied a One Health approach using human, veterinary data regarding the 2009 epidemic in The Netherlands, investigated whether observed human Q fever incidence rates were correlated risk factors. identified 158 putative (dairy goat sheep farms) included 2339 cases. performed high-resolution (1 × 1 km) zero-inflated...
Phytoplankton replace phosphorus-containing lipids (P-lipids) with non-P analogues, boosting growth in P-limited oceans. In the model diatom Thalassiosira pseudonana, substitution dynamics of lipid headgroups are well described, but those individual lipids, differing fatty acid composition, unknown. Moreover, behavior outside common headgroup classes and relationship between cellular particulate organic P (POP) have yet to be reported. We investigated these through mass spectrometric...
Introduction With the emergence of new SARS-CoV-2 variants has come significant variations in disease manifestation, severity, and duration non-hospitalized infected patients. To characterize symptom patterns risk factors associated with severity duration, COVID-19 influenza-like illness (ILI) outpatients their contacts were enrolled at two sites United States America one site Thailand. Methods infection was confirmed enrollment a positive antigen or PCR test. Baseline demographics medical...
We characterized and quantified the intact polar lipid (IPL) composition of surface waters North Sea investigated its relationships with environmental conditions, microbial abundances, community composition. The total IPL pool comprised at least 600 different species in seven main classes: glycerophospholipids phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE); sulfur‐bearing glycerolipid sulfoquinovosyldiacylglycerol (SQDG); nitrogen‐bearing betaine lipids...
Research Article| October 01, 2006 Salt-marsh erosion associated with hurricane landfall in southern New England the fifteenth and seventeenth centuries Orson van de Plassche; Plassche 1Faculty of Earth Life Sciences, Vrije Universiteit, Amsterdam, De Boelelaan 1085, 1081 HV Netherlands Search for other works by this author on: GSW Google Scholar Gilles Erkens; Erkens Frank Vliet; Vliet Joost Brandsma; Brandsma Klaas der Borg; Borg 2R.J. Van Graaff Laboratorium, Universiteit Utrecht, P.O....
Abstract. Temporal variations in the abundance and composition of intact polar lipids (IPLs) North Sea coastal marine water were assessed over a one-year seasonal cycle, compared with environmental parameters microbial community composition. Sulfoquinovosyldiacylglycerol (SQDG) was most abundant IPL class, followed by phosphatidylcholine (PC), phosphatidylglycerol (PG) diacylglyceryl-(N,N,N)-trimethylhomoserine (DGTS) roughly equal concentrations, smaller amounts phosphatidylethanolamine...
The relative flow of carbon through the viral shunt and microbial loop is a pivotal factor controlling contribution secondary production to food web rates nutrient remineralization respiration. current study examines significance these processes in coastal waters Antarctic during productive austral summer months. Throughout general trend towards lower bacterioplankton heterotrophic nanoflagellate (HNF) abundances was observed, whereas virioplankton concentration increased. A corresponding...
Objectives We evaluated the performance of commonly used sepsis screening tools across prospective cohorts in USA, Cambodia and Ghana. Design Prospective cohort studies. Setting participants From 2014 to 2021, with two or more SIRS (Systemic Inflammatory Response Syndrome) criteria suspected infection were enrolled emergency departments medical wards at hospitals Ghana hospitalised USA. Cox proportional hazards regression was performed, Harrell’s C-statistic calculated determine 28-day...