A5037427712- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Allergic Rhinitis and Sensitization
- Education, Healthcare and Sociology Research
- Palliative Care and End-of-Life Issues
- Child and Adolescent Health
- Psychiatric care and mental health services
Zealand University Hospital
2021-2022
University of Southern Denmark
2020-2022
Næstved Sygehus
2020
Systemic inflammation is a well-established feature of Chronic Obstructive Pulmonary Disease, COPD, but less known about in the upper airways disease. In current study, we investigated inflammatory profile airway and serum cohort patients with COPD. Patients were examined profiles measured on material from using 14-plex Bioplex multiplex immunoassay containing following cytokines: IL-1-beta, IL-3, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17, IL-18, Interferon-gamma, Tumour Necrosis...
Background Type 2 (T2) high asthma is recognised as a heterogenous entity consisting of several endotypes; however, the prevalence and distribution T2 biomarkers in general population, across severity, compartments largely unknown. The objective present study was to describe expression overlaps airway systemic clinically representative population. Methods Patients with from real-life BREATHE cohort referred specialist centre were included grouped according biomarkers: blood sputum...
Background: The BREATHE study is a cross-sectional of real-life patients with asthma and/or COPD in Denmark and Sweden aiming to increase the knowledge across severities combinations obstructive airway disease.Design: Patients suspicion healthy controls were invited participate had standard evaluation performed consisting questionnaires, physical examination, FeNO lung function, mannitol provocation test, allergy collection sputum blood samples. A subgroup bronchoscopy samples.Results:...
Background There is growing evidence that upper airway symptoms coexist with lower in COPD. Still, the prevalence and impact of disease on nature course COPD remain unclear. We aimed to describe this a cross-sectional study. Methods examined cohort patients pulmonary function tests, induced sputum, blood eosinophils, atopy tests computed tomography (CT) paranasal sinuses. Lower were assessed using Assessment Test (CAT), nasal subdomain 22-item Sino Nasal Outcome (SNOT22 ). recruited from...
Small Airways Disease (SAD) is a recognised part of the pathology in Chronic Obstructive Pulmonary (COPD) and contributes to symptom burden disease. Upper airway symptoms COPD an emerging field study, this we sought examine co-existence SAD upper airways cohort patients METHODS: We investigated with for presence three different modalities. performed High-Resolution CT (HRCT) Parametric Response Mapping (PRM) analysis recorded distribution emphysema (PRMEmph) functional (PRMfSAD). measured...
Objective: Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of mortality worldwide and it remains under-diagnosed. Unrecognized somatic contributes significantly to observed increased rate in patients with psychiatric diseases.Aims: To investigate whether screening spirometry simple questions on respiratory symptoms were efficacious identifying previously unknown cases COPD and/or asthma admitted wards.Methods: In this observational cohort study, we included...
<b>Background:</b> There is growing evidence that nasal symptoms coexist with lower respiratory in Chronic Obstructive Pulmonary Disease (COPD), but prevalence and impact on nature course of COPD remains unclear. We aimed to describe this a real-life, non-randomized, observational study. <b>Methods:</b> In study, we examined cohort patients confirmed (Post-BD FEV1/FVC <0.70) pulmonary function tests, induced sputum, blood eosinophils questionnaires using the assessment test (CAT score)...
<b>Background:</b> Small airways disease (SAD) and emphysema contribute to symptom burden in COPD. In this study, we sought examine the prevalence of SAD a cohort COPD patients investigate associations with lower upper airway symptoms. asthma, symptoms are associated. <b>Methods:</b> We examined from BREATHE High-Resolution CT (HRCT) subsequent Parametric Response Mapping (PRM) analysis recorded distribution (Emp<sub>PRM</sub>) functional Airways Disease (fSAD<sub>PRM</sub>). evaluated using...