A5054581648- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Medicine and Dermatology Studies History
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Advancements in Transdermal Drug Delivery
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Receptor Mechanisms and Signaling
- Cutaneous lymphoproliferative disorders research
- Myofascial pain diagnosis and treatment
- Food Allergy and Anaphylaxis Research
- Botulinum Toxin and Related Neurological Disorders
- Mast cells and histamine
- Social and Educational Sciences
- Peripheral Nerve Disorders
- Exercise and Physiological Responses
- Synthesis and properties of polymers
- Nostalgia and Consumer Behavior
- Skin Protection and Aging
- Hypothalamic control of reproductive hormones
Skåne University Hospital
2011-2024
Lund University
2014-2024
SingHealth
2019
Uppsala University
2019
Austrian Society of Dermatology and Venereology
2001-2019
Getinge (Sweden)
2009
Malmö University
1986-1987
Chronic itch is a common and distressing symptom that arises from variety of skin conditions systemic diseases. Despite this, there no clinically based classification pruritic diseases to assist in the diagnosis cost-effective medical care patients with pruritus. The proposed focuses on clinical signs distinguishes between without primary or secondary lesions. Three groups are proposed: pruritus diseased (inflamed) (group I), non-diseased (non-inflamed) II), presenting severe chronic scratch...
Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person the general population has suffered from chronic pruritus at least once lifetime with 12-month incidence of 7%. In patient populations its frequency much higher depending on underlying cause, ranging around 25% haemodialysis patients to 100% skin diseases such as urticaria and atopic dermatitis (AD). may be result dermatological or non-dermatological disease. Especially non-diseased it caused by...
Elke WEISShAAr1, Jacek C. SzEpIEToWSkI2, Ulf DArSoW3, Laurent MISEry4, Joanna WALLENgrEN5, Thomas METTANg6, Uwe gIELEr7, Torello LoTTI8, Julien LAMbErT9, peter MAISEL10, Markus STrEIT11, Malcolm W. grEAVES12, Andrew CArMIChAEL13, Erwin TSChAChLEr14, Johannes rINg3 and Sonja STaNDEr15 1Department of Clinical Social Medicine, Environmental Occupational Dermatology, Ruprecht-Karls-University Heidelberg, Germany, 2Department Venereology Allergology, Wroclaw Medical University, Poland,...
Abstract Background The term prurigo has been used for many decades in dermatology without clear definition, and currently terminology of is inconsistent confusing. Especially, itch‐related remains unexplored regarding the epidemiology, clinical profile, natural course, underlying causes, available treatments economic burden, although burdensome difficult to treat. Objective To address these issues, multicentre European Prurigo Project (EPP) was designed increase knowledge on chronic (CPG)....
Sensitive skin is a frequent complaint in the general population, patients, and among subjects suffering from itch. The International Forum for Study of Itch (IFSI) decided to initiate special interest group (SIG) on sensitive skin. Using Delphi method, was defined as "A syndrome by occurrence unpleasant sensations (stinging, burning, pain, pruritus, tingling sensations) response stimuli that normally should not provoke such sensations. These cannot be explained lesions attributable any...
The content and distribution of substance P (SP), somatostatin, vasoactive intestinal peptide (VIP), calcitonin gene-related (CGRP) neuropeptide Y (NPY) in human skin were investigated. Radioimmunoassay was performed on pooled tissue samples from several regions (fingers, toes, axillas thighs) fluid spontaneous blisters inflamed skin. Immunocytochemical localization showed all peptides examined except somatostatin to be present nerve fibers. Nerve fibers storing SP CGRP, which found coexist,...
Chronic prurigo (CPG) is a highly burdensome pruritic disease characterized by chronic itch, prolonged scratching behavior and the development of localized or generalized hyperkeratotic pruriginous lesions. Neuronal sensitization an itch-scratch cycle contribute to augmentation pruritus chronicity disease. We provide here first international guideline for rational diagnostic therapeutic approach CPG. Recommendations are based on available evidence expert opinion. The diagnosis CPG made...
Abstract The special interest group on sensitive skin of the International Forum for Study Itch previously defined as a syndrome by occurrence unpleasant sensations (stinging, burning, pain, pruritus and tingling sensations) in response to stimuli that normally should not provoke such sensations. This additional paper focuses pathophysiology management skin. Sensitive is an immunological disorder but related alterations nervous system. Skin barrier abnormalities are frequently associated,...
Abstract Background Chronic nodular prurigo (CNPG) is a condition characterized by chronic itch, prolonged scratching behaviour and the presence of pruriginous nodules. A comprehensive understanding this condition, especially regarding its clinical characteristics impact on quality life still lacking. Objectives Aim pan‐European multicentre cross‐sectional study was to establish profile CNPG, including associated burden. Methods Fifteen centres from 12 European countries recruited CNPG...
The purpose of this study was to gain an understanding why phototherapy relieves itching. Skin samples (3 mm punch biopsies) from non-inflamed gluteal skin 10 patients undergoing were compared before and after 20 treatments. All the cutaneous nerve fibres here visualized by antibodies against PGP 9.5, sensory calcitonin gene-related peptide (CGRP) capsaicin-sensitive primary nociceptive afferents VR1-receptor. Following treatment, number 9.5-positive in epidermis reduced 193 +/- 52 102 34 (p...
Immunoreactivity (IR) of substance P (SP) and Vasoactive Intestinal Peptide (VIP) were determined by radioimmunoassay in serum 56 patients with inflammatory skin diseases, blister fluid 40 spontaneous blisters 31 subjects induced blisters. Serum concentrations SP-IR VIP-IR mostly low or non-detectable. Spontaneous contained high amounts SP-IR, particularly bullous pemphigoid some dermatoses, while levels usually low. Suction from inflamed but not normal often more seldom VIP-IR.
Chronic pruritus is a frequently occurring symptom of various dermatoses that causes high burden and impaired quality life. An effective anti pruritic therapy important for the patient, but its effectiveness difficult to evaluate. Diverse methods interpretations metrics are utilized in clinical trials daily practice different countries, resulting difficulties comparing collected data.We founded European Network on Assessment Severity Burden Pruritus (PruNet) supported by EADV. PruNet...
The actions and interactions of putative mediators inflammation, such as substance P (SP), histamine, bradykinin prostaglandins (PGE2) were studied in human skin. In addition, the effects capsaicin examined it is known to release (and deplete) SP calcitonin gene‐related peptide from C‐fibres. flare evoked by was abolished pretreatment with lignocain (local anaesthetic), compound 48/80 (mast‐cell histamine liberator), mepyramine (H1‐receptor antagonist) indomethacin (cyclo‐oxygenase...
It has been reported that 10–50% of patients with pruritus but no skin rash have an underlying systemic disease and up to 70% a psychiatric one. The aim this retrospective study was review the records large number chronic for concomitant diseases treatment options. Medical 139 (52 males, 87 females) who visited outpatient dermatological clinic during 17-month period were reviewed. Itch presenting symptom in 6 47 17 31 disease. Twenty-four had neuropathic itch 37 unknown origin. most severe...
The mast cell granule metalloprotease CPA3 is proposed to have important tissue homeostatic functions. However, the basal mRNA and protein expression among populations has remained poorly investigated. Using a novel histology-based methodology that yields quantitative data on at single-cell level, present study maps throughout MCT MCTC in healthy skin, gut lung tissues. cells had both higher frequency of protein-containing protein-staining intensity than population. Among tissues, skin MCs...