A5091553385- Inflammatory Bowel Disease
- Microscopic Colitis
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Biosimilars and Bioanalytical Methods
- Immunodeficiency and Autoimmune Disorders
- Spondyloarthritis Studies and Treatments
- Eosinophilic Esophagitis
- Dermatology and Skin Diseases
- Systemic Sclerosis and Related Diseases
- Cerebrovascular and Carotid Artery Diseases
- Folate and B Vitamins Research
- Pregnancy and Medication Impact
- Ultrasound and Hyperthermia Applications
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Therapeutic Uses of Natural Elements
- Gastrointestinal motility and disorders
- Immune Response and Inflammation
- Gastrointestinal Bleeding Diagnosis and Treatment
- Mast cells and histamine
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psoriasis: Treatment and Pathogenesis
Lund University
2016-2025
Skåne University Hospital
2016-2025
Leiden University Medical Center
2023
King's College London
2023
Getinge (Sweden)
2022
University of Padua
2021
XinHua Hospital
2019
Sahlgrenska University Hospital
2014
Ludwig-Maximilians-Universität München
2006
Universidad Autónoma de Madrid
2006
CD103+CD11b+ dendritic cells (DCs) represent the major migratory DC population within small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a deletion Irf4 displayed reduced numbers of interleukin 17 (IL-17)-secreting helper T (Th17) and failed to support Th17 cell differentiation draining mesenteric lymph nodes (MLN) following immunization. The latter associated...
Immune checkpoint inhibitors (ICPI), such as ipilimumab [anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibody] and nivolumab or pembrolizumab [anti-programmed cell death protein-1 (PD-1) antibodies], improve survival in several cancer types. Since inhibition of CTLA-4 PD-1 leads to non-selective activation the immune system, immune-related adverse events (irAEs) are frequent. Enterocolitis is a common irAE, currently managed with corticosteroids and, if necessary, anti-tumor necrosis...
Abstract The mucosal lymphocyte integrin αE(CD103)β7 is thought to be important for intraepithelial (IEL) localization or function. We cloned the murine gene encoding αE, localized it chromosome 11, and generated αE-deficient mice. In αE−/− mice, intestinal vaginal IEL numbers were reduced, consistent with known binding of αEβ7 E-cadherin expressed on epithelial cells. However, was surprising that lamina propria T diminished, as not in propria. contrast, peribronchial, intrapulmonary,...
The recruitment of antigen-specific T lymphocytes to the intestinal mucosa is central development an effective mucosal immune response, yet mechanism by which this process occurs remains be fully defined. Here we show that CC chemokine receptor 9 (CCR9) selectively and functionally expressed on murine αEβ7+ naive CD8αβ+ a subset recently activated CD69+ lymphocytes. Using cell transgenic transfer model, demonstrate CCR9 expression maintained following activation in mesenteric lymph nodes but...
The recruitment of antigen-specific T lymphocytes to the intestinal mucosa is central development an effective mucosal immune response, yet mechanism by which this process occurs remains be fully defined. Here we show that CC chemokine receptor 9 (CCR9) selectively and functionally expressed on murine αEβ7+ naive CD8αβ+ a subset recently activated CD69+ lymphocytes. Using cell transgenic transfer model, demonstrate CCR9 expression maintained following activation in mesenteric lymph nodes but...
Altered microbial composition of the intestine, commonly referred to as dysbiosis, has been associated with several autoimmune diseases including primary Sjögren's syndrome (pSS). The aims current study were intestinal balance in pSS and identify clinical features dysbiosis.Forty-two consecutive patients 35 age-matched sex-matched control subjects included an open clinic setting. Stool samples analyzed for dysbiosis using a validated 16S rRNA-based microbiota test (GA-map™ Dysbiosis Test;...
Recent evidence suggests a link between autoimmunity and the intestinal microbial composition in several rheumatic diseases including systemic sclerosis (SSc). The objective of this study was to investigate prevalence dysbiosis SSc characterise patients suffering from potentially immunomodulatory deviation. This consisted 98 consecutive subject in-hospital care. Stool samples were analysed for microbiota using validated genome-based test (GA-map™ Dysbiosis Test, Genetic Analysis, Oslo,...
Clinical trials have demonstrated the efficacy of vedolizumab in inflammatory bowel disease (IBD). However, these findings may not reflect clinical practice. Therefore, we aimed to describe a vedolizumab-treated patient population and assess long-term effectiveness.Patients initiating between 1 June 2014 30 May 2015 were identified through Swedish National Quality Registry for IBD. Prospectively collected data on treatment activity extracted. remission was defined as Patient Harvey Bradshaw...
Summary Background and Aims Vedolizumab is a gut‐selective treatment approved for Crohn’s disease (CD) ulcerative colitis (UC). Recently, subcutaneous formulation of vedolizumab was approved. The aims this study were to evaluate efficacy, safety, pharmacokinetics, patient experience costs following switch from intravenous treatment. Methods Patients switched maintenance followed prospectively 6 months subgroup 12 months. primary endpoint change in faecal calprotectin levels. Furthermore, we...
Abstract γδ T cells have been attributed a wide variety of functions, which in some cases may appear as contradictory. To better understand the enigmatic biology it is crucial to define constituting subpopulations. previously categorized into two subpopulations: CD8αα+ and CD8− cells. In this study we defined characterized novel subset human T-cells expressing CD8αβ. These CD8αβ+ differed from described cell subsets several aspects, including degree enrichment within gut mucosa, activation...
BackgroundWhether infliximab therapy can be successfully discontinued after patients with Crohn’s disease have attained sustained, clinical, biochemical, and endoscopic remission is unknown.MethodsWe conducted a multicenter, randomized, double-blind, placebo-controlled withdrawal study of in who were standard maintenance for at least 1 year. Patients randomly assigned 1:1 to continue or receive matching placebo 48 weeks. The primary end point was time relapse.ResultsThis 115 either the...
Based on clinical and genetic associations, axial spondyloarthritis (axSpA) inflammatory bowel disease (IBD) are suspected to have a linked pathogenesis. Gut dysbiosis, intrinsic IBD, has also been observed in axSpA. It is, however, not established what degree gut dysbiosis is associated with axSpA severity. The objective of this study was compare frequency between controls, non-radiographic (nr-axSpA), ankylosing spondylitis (AS) patients investigate whether cross-sectionally activity,...
It is uncertain whether the risk of major congenital anomalies (mCAs) increased in children women with inflammatory bowel disease (IBD). We aimed to determine mCAs a Swedish nationwide cohort 13,131 singleton live births from 1997 2020 IBD and 61,909 matched without general population. additionally examined according periconceptional histological inflammation (vs remission: 1,124 646 births, respectively) or clinically active quiescent: 3,380 6,603 respectively). Adjusted ratios (aRRs) for...
Purpose: There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of Swedish inception cohort IBD (SIC-IBD) demonstrate its potential identification such signatures. Participants: Patients aged 18 years or older with gastrointestinal symptoms who were referred gastroenterology unit due suspected at eight hospitals between November 2011 March 2021 eligible inclusion. Findings date: In...
Abstract Background Fatigue is characterized as an overwhelming sense of tiredness, weakness, or exhaustion, which can be physical, psychological, a combination both. common symptom and significant concern for patients with IBD. International studies indicate that between 44% 86% active disease, 22% to 41% those in remission, experience fatigue. This limit individual activities negatively impact health-related quality life. Despite its profound effects on patients, fatigue often overlooked...
Mucosal tissues contain large numbers of memory CD4+ T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance tissue integrity. Here we identify major subset at surfaces that coexpress interleukin-18 receptor alpha (IL-18Rα) death receptor-3 (DR3), display innate lymphocyte functionality. The cytokines IL-15 or the DR3 ligand tumor necrosis factor (TNF)-like cytokine 1A (TL1a) induced...
Background Real-life long-term data on infliximab treatment in ulcerative colitis are limited. Aim To study the efficacy and safety of chronic active possible predictors colectomy response were also examined. Methods A retrospective multi-centre 250 patients with inclusion criteria: age ≥18 years, ambulatory treated, steroid-dependent or intolerant and/or immunomodulator refractory intolerant. Results Steroid-free clinical remission was achieved by 123/250 (49.2%) at 12 months 126/250 a...
The mast cell granule metalloprotease CPA3 is proposed to have important tissue homeostatic functions. However, the basal mRNA and protein expression among populations has remained poorly investigated. Using a novel histology-based methodology that yields quantitative data on at single-cell level, present study maps throughout MCT MCTC in healthy skin, gut lung tissues. cells had both higher frequency of protein-containing protein-staining intensity than population. Among tissues, skin MCs...