A5075584909- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Allergic Rhinitis and Sensitization
- Pharmacological Effects and Assays
- Cystic Fibrosis Research Advances
- Reproductive System and Pregnancy
- Cardiovascular and exercise physiology
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Occupational exposure and asthma
- Exercise and Physiological Responses
- Thermoregulation and physiological responses
- Pregnancy and preeclampsia studies
- Pediatric health and respiratory diseases
- Dysphagia Assessment and Management
- Neuroscience of respiration and sleep
- Phagocytosis and Immune Regulation
- Heart Rate Variability and Autonomic Control
- Sports Performance and Training
- Infection Control and Ventilation
- Cardiovascular Effects of Exercise
- Astrophysics and Cosmic Phenomena
- Particle accelerators and beam dynamics
The University of Sydney
2001-2023
Royal Prince Alfred Hospital
2008-2018
Jones Institute
2010-2014
Eastern Virginia Medical School
2010-2014
Interstitial Cystitis Association
2013
University of Arizona
2013
University of Aberdeen
2007
Svenska Örtmedicinska Institute
2007
Karolinska Institutet
2007
Monash University
2002-2003
Asthma and chronic obstructive pulmonary disease (COPD, also called airflow limitation (CAL)) are the most frequent diagnoses in patients with intrathoracic airways obstruction [1]. Often these show a spontaneous variability degree of obstruction, which can be documented by serial lung function measurements. Large is indicative an increased susceptibility patient to environmental stimuli that cause acute airway narrowing. Knowledge potential severity episodes clinical interest. Therefore,...
Section:ChooseTop of pageAbstract <<ContentsExecutive SummaryIntroductionMethodsPathogenesisRole the EnvironmentDiagnosisTreatmentScreening for EIBExercise, Asthma, and Dop...ReferencesCITING ARTICLES
To assess non-specific bronchial reactivity the effect of inhaling ultrasonically nebulised solutions distilled water and hypotonic (0.3%), isotonic (0.9%), hypertonic (2.7%, 3.6%) saline was investigated in 10 asthmatic patients nine normal subjects. Expired ventilation maximum percentage fall forced expiratory volume one second (FEV1) were recorded. The sensitivity to inhaled determined by measuring required induce a FEV1 20% from prechallenge value. Hypotonic but not caused significant...
Asthmatic children, known to be susceptible exercise-induced bronchoconstriction, exercised by running or walking on a treadmill. Changes in airways obstruction were estimated measurement of peak expiratory flow rate before, during, and after exercise. Post exercise bronchoconstriction reached maximum when the duration was 6 8 minutes gradient treadmill 10 15%; for longer periods at steeper gradients produced no significant increase bronchoconstriction. Bronchoconstriction much greater than...
To determine predictors for failed reduction of inhaled corticosteroids (ICS), in 50 subjects with well-controlled asthma (age 43.7 [18–69]; 22 males) taking a median dose 1,000 μ g ICS/d (100–3,600 g/d), ICS were halved every 8 wk. Airway hyperresponsiveness (AHR) to bronchial provocation test (BPT) histamine was measured at baseline. AHR BPT mannitol, spirometry, exhaled nitric oxide (eNO), and, 31 subjects, sputum inflammatory cells baseline and monthly intervals. Thirty-nine suffered an...
We developed a bronchial provocation test (BPT) with dry powder preparation of mannitol. The mannitol was inhaled from gelatin capsules containing 5, 10, 20, or 40 mg to cumulative dose 635 mg, and delivered via an Inhalator, Halermatic, Dinkihaler device. studied the airway sensitivity mannitol, repeatability response, recovery after challenge in 43 asthmatic subjects 18 39 yr age who had 20% decrease FEV1 response inhaling 4.5% NaCl. compared this methacholine 25 subjects. geometric mean...
The prevalence of bronchial hyperresponsiveness in adult populations is not known. To document its and distribution to determine the factors associated with it, a random sample population Busselton, Western Australia, was studied. Spirometric function, responsiveness histamine, atopic responses skin prick tests were measured. Respiratory symptoms determined by questionnaire. Data obtained from 916 subjects. Of these, 876 underwent histamine inhalation test (defined as dose provoking 20% fall...
Abstract Background Inhaled mannitol is a new bronchial provocation test (BPT) developed to improve portability and standardisation of osmotic challenge testing. Osmotic tests have an advantage over the traditional methods measuring airway hyperresponsiveness using methacholine as they demonstrate higher specificity identify asthma thus need for treatment with inhaled corticosteroids (ICS). The safety efficacy (M) BPT measure were compared hypertonic (4.5%) saline (HS) in people both without...
The airway response to the inhalation of ultrasonically nebulised distilled water was determined in 55 asthmatic patients and 16 normal subjects. We calculated dose required induce a 20% reduction (PD20) forced expiratory volume one second (FEV1) by measuring output nebuliser ventilated each subject. Forty-eight had PD20 9 ml or less but three as much 24 ml. A not recorded subjects challenge stopped after 33 In 12 repeated within six months shown be reproducible at equivalent doses water....
Hyperosmolarity of the airway surface liquid (ASL) has been proposed as stimulus for hyperpnoea-induced asthma. We found previously that mucociliary clearance (MCC) was increased after isocapnic hyperventilation (ISH) with dry air, and we increase related to transient hyperosmolarity ASL. investigated effect increasing osmolarity ASL on MCC, by administering an aerosol concentrated salt solution. MCC measured using 99mTc-sulphur colloid, gamma camera computer analysis in 12 asthmatic 10...
Asthma can be difficult to diagnose, but bronchial provocation with methacholine, exercise or mannitol is helpful when used identify hyperresponsiveness (BHR), a key feature of the disease. The utility these tests in subjects signs and symptoms asthma without clear diagnosis has not been investigated. We investigated sensitivity specificity exercise-induced bronchoconstriction (EIB) as manifestation BHR; compared this methacholine; methacholine for clinician asthma. 509 people (6–50 yr) were...