A5062315448- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Mesenchymal stem cell research
- Pulmonary Hypertension Research and Treatments
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- Complementary and Alternative Medicine Studies
- Disaster Response and Management
- Acupuncture Treatment Research Studies
- Veterinary Equine Medical Research
- Veterinary Pharmacology and Anesthesia
- Atherosclerosis and Cardiovascular Diseases
- Pain Management and Placebo Effect
- Trauma and Emergency Care Studies
- Global Cancer Incidence and Screening
- AI in cancer detection
- Obstructive Sleep Apnea Research
- Immune Cell Function and Interaction
- TGF-β signaling in diseases
- Olfactory and Sensory Function Studies
Aston University
2014-2024
Allina Health
2014-2016
Penny George Institute for Health and Healing
2014-2016
Karolinska Institutet
2009-2015
Lung Institute
2015
Imperial College London
2012-2015
National Institutes of Health
2012-2015
University of Minnesota
1992-2014
University of Minnesota Medical Center
2014
Abbott Northwestern Hospital
2014
It is now fully appreciated that asthma a disease of chronic nature resulting from intermittent or continued aeroallergen exposure leading to airway inflammation. To investigate responses continuous antigen exposure, mice were exposed either house dust mite extract (HDM) ovalbumin intranasally for five consecutive days, followed by 2 days rest, up seven weeks. Continuous HDM, unlike ovalbumin, elicited severe and persistent eosinophilic Flow cytometric analysis demonstrated an accumulation...
Objective— To characterize equine adipose tissue‐derived stromal cell (ASC) frequency and growth characteristics assess of their adipogenic osteogenic differentiation potential. Study Design— In vitro experimental study. Animals— Horses (n=5; aged, 9 months to 5 years). Methods— Cell doubling ASCs harvested from supragluteal subcutaneous tissue were evaluated over 10 passages. Primary, second (P2), fourth (P4) passage induced under appropriate conditions undergo adipogenesis osteogenesis....
Objectives— To characterize equine bone marrow (BM)‐derived mesenchymal stem cell (MSC) growth characteristics and frequency as well their adipogenic osteogenic differentiation potential. Study Design— In vitro experimental study. Animals— Foals (n=3, age range, 17–51 days) young horses (n=5, 9 months to 5 years). Methods— Equine MSCs were harvested isolated from sternal BM aspirates grown up passage 10 determine cell‐doubling (CD) characteristics. Limit dilution assays performed on primary...
Objective— To compare the chondrogenic potential of adult equine mesenchymal stem cells derived from bone marrow (MSCs) or adipose tissue (ASCs). Study Design— In vitro experimental study. Animals— Adult Thoroughbred horses (n=11). Methods— BM (5 horses; mean [±SD] age, 4±1.4 years) (6 3.5±1.1 samples were obtained. Cryopreserved MSCs and ASCs used for pellet cultures in stromal medium (C) induced into chondrogenesis±transforming growth factor‐3 (TGFβ 3 ) morphogenic factor‐6 (BMP‐6)....
Chronic allergic asthma is characterized by Th2-polarized inflammation and leads to airway remodeling fibrosis but the mechanisms involved are not clear. To determine whether epithelial-mesenchymal transition contributes in asthma, we induced mice intranasal administration of house dust mite (HDM) extract for up 15 consecutive weeks. We report that respiratory exposure HDM led significant thickening smooth muscle layer wall large airways. Transforming growth factor beta-1 (TGF-β1) levels...
Therapy-induced resistance remains a significant hurdle to achieve long-lasting responses and cures in cancer patients. We investigated the long-term consequences of genetically impaired angiogenesis by engineering multiple tumor models deprived endoglin, co-receptor for TGF-β endothelial cells actively engaged angiogenesis. Tumors from endoglin-deficient mice adapted weakened angiogenic response, refractoriness diminished endoglin signaling was accompanied increased metastatic capability....
It is now believed that both chronic airway inflammation and remodeling contribute significantly to dysfunction clinical symptoms in allergic asthma. Transforming growth factor (TGF)-beta a powerful regulator of the tissue repair inflammatory responses, numerous experimental studies suggest it may play an integral role pathogenesis asthma.We investigated TGF-beta regulation using mouse model house dust mite (HDM)-induced disease.We have previously shown intranasal administration HDM extract...
Allergic asthma is characterized by airway inflammation in response to antigen exposure, leading remodeling and lung dysfunction. Epithelial-mesenchymal transition (EMT) may play a role through the acquisition of mesenchymal phenotype epithelial cells. TGF-β1 known promote EMT; however, other cytokines expressed severe with extensive remodeling, such as IL-22, also contribute this process. In study, we evaluated contribution IL-22 EMT primary bronchial cells from healthy asthmatic...
Mouse models of allergic airway disease have greatly contributed to our understanding induction and pathogenesis. Although these typically investigate responses a single antigen or allergen, humans are frequently exposed myriad allergens, each with distinct antigenic potential.Given that exposure ovalbumin (OVA), prototypic innocuous antigen, induces inhalation tolerance, we wished how this response would be altered if OVA were encountered concurrently house dust mite extract (HDM), which...
Eight cases of hepatitis due to herpes simplex virus (HSV) (five "confirmed," three "possible") were identified among marrow-transplant recipients at the Fred Hutchinson Cancer Research Center between 1975 and 1988. The clinical pathological characteristics these patients are described compared with published findings for non-marrow-transplant HSV hepatitis. Clinical syndromes in ranged from fever associated abdominal pain elevations serum aminotransferase levels fulminant Evidence hepatic...
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Few studies have investigated the effectiveness of integrative medicine (IM) therapies on pain and anxiety among oncology inpatients.Retrospective data obtained from electronic medical records identified patients with an International Classification Diseases-9 code who were admitted to a large Midwestern hospital between July 1, 2009 December 31, 2012. Outcomes change in patient-reported anxiety, rated before after individual IM treatment sessions, using numeric scale (0-10).Of 10948...
Myofibroblast accumulation, subepithelial fibrosis, and vascular remodeling are complicating features of chronic asthma, but the mechanisms not clear. Platelet-derived growth factors (PDGFs) regulate fate function various mesenchymal cells have been implicated as mediators lung fibrosis. However, it is known whether PDGF-BB signaling via PDGFRβ, which critical for recruitment pericytes to blood vessels, plays a role in airway asthma. In present study, we used selective PDGFRβ inhibitor...
Given the risks of opioid medications, nonpharmacological strategies should be considered for total joint replacement patients. We investigated acupuncture as an adjunct therapy postsurgical pain management in a program by examining which hip and knee patients elected to receive effect on short-term pain. A using fast-track physiotherapy offered elective all patients, at no additional cost, opioids management. The Joint Replacement Center Abbott Northwestern Hospital, 630-bed teaching...
The incidence of sleep-related breathing disorders is correlated with lower and upper airway inflammatory diseases, such as asthma allergic rhinitis. We hypothesized that corticosteroids treatment would lead to a greater reduction in disease severity obstructive sleep apnoea syndrome (OSAS) patients concomitant rhinitis vs. non-allergic OSAS by reducing the level inflammation tissues.This study was performed determine whether intranasal could reduce improve parameters or without...