A5049082461- Advanced Electron Microscopy Techniques and Applications
- Electron and X-Ray Spectroscopy Techniques
- Neonatal Respiratory Health Research
- Electronic and Structural Properties of Oxides
- Asthma and respiratory diseases
- Magnetic and transport properties of perovskites and related materials
- Congenital Diaphragmatic Hernia Studies
- Integrated Circuits and Semiconductor Failure Analysis
- Magnetic properties of thin films
- Advanced Materials Characterization Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced Condensed Matter Physics
- Advanced X-ray Imaging Techniques
- Inhalation and Respiratory Drug Delivery
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immune Response and Inflammation
- Platelet Disorders and Treatments
- Epigenetics and DNA Methylation
- Particle Detector Development and Performance
- Advanced Surface Polishing Techniques
- Machine Learning in Materials Science
- Estrogen and related hormone effects
- Theoretical and Computational Physics
- Multiferroics and related materials
- Cell Image Analysis Techniques
Norwegian University of Science and Technology
2013-2025
AstraZeneca (Sweden)
2007-2023
University of Antwerp
2019-2023
AstraZeneca (Brazil)
2023
National Patient Safety Foundation
2021-2023
University of Glasgow
2016-2021
AstraZeneca (United Kingdom)
2021
AstraZeneca (United States)
2021
Scottish Universities Physics Alliance
2017
University of California, Davis
2017
Scanning transmission electron microscopy (STEM) data with atomic resolution can contain a large amount of information about the structure crystalline material. Often, this is hard to extract, due number columns and differences in intensity from sublattices consisting different elements. In work, we present free open source software tool for analysing both position shapes STEM-images, using 2-D elliptical Gaussian distributions. The tested on variants perovskite oxide structure. By first...
Abstract Background Leukotrienes ( LT s) are potent pro‐inflammatory mediators involved in asthma. Exosomes, nanosized vesicles released from various cells, can stimulate or down‐regulate immune responses, depending on the state and nature of originating cell. We have recently shown an altered exosome profile bronchoalveolar lavage fluid BALF ) patients with sarcoidosis, but their role asthma is unknown. Our aims were to investigate whether exosomes biosynthetic capacity explore phenotypic...
Estrogens have well-documented effects on lung development and physiology. However, the classical estrogen receptor alpha (ERalpha) is undetectable in lung, this has left many unanswered questions about mechanism of action organ. Here we show, both vivo vitro, that ERbeta abundantly expressed biologically active lung. Comparisons lungs from wild-type mice with an inactivated gene (ERbeta(-/-)) revealed decreased numbers alveoli adult female ERbeta(-/-) findings suggesting deficient alveolar...
Chronic allergic asthma is characterized by Th2-polarized inflammation and leads to airway remodeling fibrosis but the mechanisms involved are not clear. To determine whether epithelial-mesenchymal transition contributes in asthma, we induced mice intranasal administration of house dust mite (HDM) extract for up 15 consecutive weeks. We report that respiratory exposure HDM led significant thickening smooth muscle layer wall large airways. Transforming growth factor beta-1 (TGF-β1) levels...
A diagnosis of aspirin-intolerant asthma requires aspirin provocation in specialist clinics. Urinary leukotriene E(4) (LTE(4)) is increased asthma. study was undertaken to investigate new biomarkers intolerance by comparing basal levels cysteinyl-leukotrienes (CysLTs) and B(4) (LTB(4)) saliva, sputum ex vivo stimulated blood subjects with aspirin-tolerant The effects aspirin- allergen-induced bronchoconstriction on saliva were also compared the provocations urinary mediators.Induced sputum,...
Vertically aligned radial-junction solar cell designs offer potential improvements over planar geometries, as carrier generation occurs close to the junction for all absorption depths, but most production methods still require a single crystal substrate. Here, we report on fabrication of such cells from polycrystalline, low purity (99.98%) p-type silicon starting material, formed into core, silica sheath fibres using bulk glass draw techniques. Short segments were cut and was etched one...
We report on the optimisation of amorphous molybdenum silicide thin film growth for superconducting nanowire single-photon detector (SNSPD) applications. Molybdenum was deposited via co-sputtering from Mo and Si targets in an Ar atmosphere. The transition temperature (Tc) sheet resistance (Rs) were measured as a function thickness compared to several theoretical models disordered films. Superconducting optical properties materials are very sensitive short- (up 1 nm) medium-range order (∼1–3...
Background Fractional exhaled nitric oxide is elevated in allergen-provoked asthma. The cellular and molecular source of the fractional is, however, uncertain. Objective To investigate whether associated with increased airway epithelial inducible synthase (iNOS) Methods was measured healthy controls (n = 14) allergic asthmatics 12), before after bronchial provocation to birch pollen out season. Bronchoscopy performed 24 hours allergen provocation. Bronchial biopsies brush were processed for...
Using Scanning Transmission Electron Microscopy (STEM) coupled with Dual Energy Loss Spectroscopy (DualEELS) and scanned diffraction, the corrosion incorporation of Secondary Phase Particles (SPPs) in oxide layer Zircaloy-4 material has been investigated. This study focuses on mapping Zr2Fe Zr(Fe, Cr)2 precipitates during oxidation process depicting their morphology as front advances through material. It found that SPPs retain same general shape pre stage, transform to a nanocrystalline...
Clausen et al., (2020). LiberTEM: Software platform for scalable multidimensional data processing in transmission electron microscopy. Journal of Open Source Software, 5(50), 2006, https://doi.org/10.21105/joss.02006
FeSn is a room-temperature antiferromagnet composed of alternating Fe3Sn kagome layers and honeycomb Sn layers. Its distinctive lattice allows the formation linearly dispersing Dirac bands topological flatbands in its electronic band structure, positioning as an ideal candidate for investigating interplay between magnetism topology. In this study, we investigate epitaxial growth thin films on GaAs(111) substrates by molecular beam epitaxy. A significant challenge process diffusion Ga As from...
We describe here the cloning and characterization of a novel member thioredoxin family, thioredoxin-like protein 2 (Txl-2). The Txl-2 open reading frame codes for 330 amino acids consisting two distinct domains: an N-terminal domain typical thioredoxins C-terminal belonging to nucleoside-diphosphate kinase separated by small interface domain. gene spans ∼28 kb, is organized into 11 exons, maps at locus 3q22.3-q23. A splicing variant lacking exon 5 (Δ5Txl-2) has also been isolated. By...
Clara cell secretory protein (CCSP) is a product of nonciliated cells the conducting airway epithelium. The normal physiological function CCSP unknown. However, ability to bind small lipophilic molecules, such as steroid hormones and certain pollutants, has led speculation that this may mediate biological accumulation potentially harmful polychlorinated biphenyl (PCB) metabolites within lung. To investigate contribution in vivo methylsulfonyl-PCB, line mice was established were homozygous...
Estrogen, mainly estradiol (E2), and progesterone (P) are essential for the growth differentiation of breast, but their roles in breast cancer highly debated. To understand how E2 P influence cell proliferation differentiation, it is to know receptors regulated. Because limited tissue availability, little known about regulation two estrogen (ERα ERβ) receptor isoforms (PR-A PR-B) normal human breast. What we comes from rodent studies, which not always pertinent We report now on gonadal...
Allergic asthma is caused by allergen-specific IgE and T-helper cell (Th) type 2 responses towards airborne allergens. The objective of this study was to investigate local systemic regulatory mechanisms in the early asthmatic response bronchial allergen provocation.Birch pollen-allergic patients with mild (n = 13) healthy nonallergic controls 14) were subjected bronchoalveolar lavage (BAL) blood sampling. On BAL performed twice: without preceding provocation ('before samples') 24 h after...
An oxygen vacancy driven structural response at the epitaxial interface between La0.7Sr0.3MnO3 films and SrTiO3 substrates is reported. A combined scanning transmission electron microscopy energy loss spectroscopy study reveal presence of an elongated out-of-plane lattice parameter, coupled to vacancies reduced manganese oxidation state side interface. Density functional theory calculations support that measured structure a disordered deficient brownmillerite structure. The effect mobility...
Nanoscale modifications of strain and magnetic anisotropy can open pathways to engineering domains for device applications. A periodic domain structure be stabilized in sub-200 nm wide linear as well curved magnets, embedded within a flat non-ferromagnetic thin film. The nanomagnets are produced B2-ordered Fe60 Al40 film, where local irradiation by focused ion beam causes the formation disordered strongly ferromagnetic regions A2 . An anisotropic lattice relaxation is observed, such that...
The link between respiratory complications in prematurely born infants and susceptibility for developing chronic obstructive pulmonary disease (COPD) is receiving increasing attention. We have previously found that CCAAT/enhancer binding protein (C/EBP) activity airway epithelial cells of COPD patients decreased compared to healthy smokers, suggesting a unknown role C/EBPs pathogenesis. To investigate the transcription factor C/EBPα lung development its potential COPD, mice with...
In crystalline thin film growth a prerequisite is substrate surfaces with stable and uniform structure chemical composition. Various treatments were used to obtain atomically smooth, step-and-terrace (111)-oriented SrTiO3 cation layers at the surface, i.e., single termination. The surface control enables subsequent layer-by-layer epitaxial of perovskite films La0.7Sr0.3MnO3, LaFeO3, BaTiO3. Reflection high-energy electron diffraction energy loss spectroscopy revealed that chemically...
The use of fast pixelated detectors and direct electron detection technology is revolutionizing many aspects scanning transmission microscopy (STEM). widespread adoption these new technologies impeded by the technical challenges associated with them. These include issues related to hardware control, acquisition, real-time processing visualization, storage data from such detectors. We discuss problems present software solutions for them, a view making benefits in context STEM more accessible....