A5028636644- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Kruppel-like factors research
- Heusler alloys: electronic and magnetic properties
- Magnetic properties of thin films
- Magnetic Properties of Alloys
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- ZnO doping and properties
Norwegian University of Science and Technology
2023-2025
Yale University
2022-2024
FeSn is a room-temperature antiferromagnet composed of alternating Fe3Sn kagome layers and honeycomb Sn layers. Its distinctive lattice allows the formation linearly dispersing Dirac bands topological flatbands in its electronic band structure, positioning as an ideal candidate for investigating interplay between magnetism topology. In this study, we investigate epitaxial growth thin films on GaAs(111) substrates by molecular beam epitaxy. A significant challenge process diffusion Ga As from...
Background: The phenotypic plasticity of vascular smooth muscle cells is central to growth and remodeling processes, but also underlies many cardiovascular pathologies, including atherosclerosis, restenosis, intimal hyperplasia. This ability VSMCs reversibly differentiate dedifferentiate incompletely understood. SUV39H1, a histone methyltransferase, that generates the H3K9Me3 mark results in epigenetic transcriptional repression. We hypothesized SUV39H1 plays key role VSMC plasticity....
Abstract Background Reversible DNA methylation contributes to the phenotypic plasticity of vascular smooth muscle cells (VSMCs). This growth remodeling, but also underlies cardiovascular pathologies, including intimal hyperplasia. We investigated role SUV39H1, a histone methyltransferase that generates H3K9me3 repressive epigenetic mark, in VSMC Methods applied knockdown, qPCR, western blotting, chromatin immunoprecipitation (ChIP) assays, and RNA-Seq human coronary artery SMCs (hCASMCs),...
Surface morphology and magnetic properties of ferromagnetic Heusler alloy Co2FeSi thin films their multi-layers with anti-ferromagnetic Ir50Mn50, which find applications in spintronic devices were investigated. The sputtering process flow for large area deposition on 3 inch size thermally oxidized single crystal Si(100)/SiO2 substrates have been developed by optimizing the geometry other parameters. A uniform film composition, thickness, smooth surface, good crystallinity achieved over...
The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to growth and remodeling processes, but also contributes the pathology atherosclerosis, restenosis, other cardiovascular diseases. This ability VSMCs reversibly differentiate de-differentiate incompletely understood. SUV39H1, a histone methyltransferase, specifically trimethylates Lys-9 H3 (H3K9me3), resulting in epigenetic transcriptional repression. We hypothesized that SUV39H1 plays role VSMC switching. Using...
Vascular smooth muscle cell (VSMC) phenotypic switching contributes to cardiovascular diseases. Epigenetic regulation is emerging as a key regulatory mechanism, with the methyl cytosine dioxygenase TET2 acting master regulator of SMC phenotype. The histone acetyltransferases (HATs) p300 and CBP are highly homologous often considered be interchangeable, their roles in not known. We assessed human VSMC knockdown, inducible muscle-specific knockout mice ( iKO or ), intimal hyperplasia. P300,...
Introduction: The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to growth and remodeling processes, but also contributes cardiovascular disease. This unique ability VSMCs reversibly differentiate de-differentiate incompletely understood. SUV39H1 a histone methyltransferase that specifically trimethylates Lysine-9 H3 (H3K9me3), resulting in transcriptional repression through epigenetic gene silencing. Hypothesis: We hypothesized may play role SMC switch. Methods:...