A5101604058- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Retinoids in leukemia and cellular processes
- Neuroendocrine regulation and behavior
- Infant Health and Development
- Neuroscience of respiration and sleep
- Visual perception and processing mechanisms
- Vagus Nerve Stimulation Research
- Hedgehog Signaling Pathway Studies
- RNA regulation and disease
- Nicotinic Acetylcholine Receptors Study
- Endoplasmic Reticulum Stress and Disease
- Neonatal Respiratory Health Research
- Muscle activation and electromyography studies
- Neurobiology and Insect Physiology Research
- EEG and Brain-Computer Interfaces
- Folate and B Vitamins Research
- Neurological disorders and treatments
- Motor Control and Adaptation
- RNA Research and Splicing
- Photoreceptor and optogenetics research
- Animal Vocal Communication and Behavior
- Sympathectomy and Hyperhidrosis Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Nerve injury and regeneration
New York University
2016-2024
Yale University
1992-2024
University School
2022-2023
Howard Hughes Medical Institute
2015-2022
Janelia Research Campus
2016-2022
ORCID
2021
Creative Commons
2021
Enzo Life Sciences (United States)
2018
Neurosciences Institute
2016
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2013
The standard one-dimensional Rall cable model assumes that the electrotonic structure of neurons does not change in response to synaptic input. This is used a great number both theoretical and anatomical-physiological structure-function studies. In particular, membrane time constant, tau m, somatic input resistance, Rin, length are characterize single cells. However, these studies do take into account embedded network spontaneously active Synapses from cells will contribute significantly...
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression proteins in cells. Various insults activate kinases that phosphorylate GTPase eIF2 leading to inhibition its exchange factor eIF2B. Vanishing White Matter (VWM) is a neurological disease caused by eIF2B mutations that, like phosphorylated eIF2, reduce activity. We show introduction human VWM mutation into mice leads persistent ISR induction central nervous system. activation precedes...
The interaction of descending neocortical outputs and subcortical premotor circuits is critical for shaping skilled movements. Two broad classes motor cortical output projection neurons provide input to many areas: pyramidal tract (PT) neurons, which project throughout the neuraxis, intratelencephalic (IT) within cortex striatum. It unclear whether these are functionally in series or each class carries distinct components control signals. Here, we combine large-scale neural recordings across...
The action potential discharge response of single neurons to both visual stimulation and injections current were obtained during intracellular recordings in cat cortex order estimate the net excitatory arriving at soma stimulation. Of 45 recorded intracellularly, 19 pyramidal one basket cell labelled with horseradish peroxidase. all adapted constant current. For 40 neurons, a exponential provided good fit adapting (r2 = 0.73 +/- 0.03) for intensities. Superficial layer significantly faster...
The posterior lateral line primordium (PLLp) migrates caudally and periodically deposits neuromasts. Coupled, but mutually inhibitory, Wnt-FGF signaling systems regulate proto-neuromast formation in the PLLp: FGF ligands expressed response to Wnt activate receptors initiate formation. receptor signaling, turn, inhibits signaling. However, mechanisms that determine periodic neuromast deposition PLLp remain poorly understood. Previous studies showed neuromasts are deposited closer together...
Abstract Microtubule associated proteins (MAPs) interact with tubulin to modulate neurite stability and growth during development. The phosphorylated form of one these MAPs, MAP1B (MAP1B‐P) is hypothesized be particular importance for the regulation outgrowth. To investigate mechanisms by which MAP1B‐P contribute this regulation, we used a new antibody against an isoform determine its pattern expression neuronal development in vitro. We examined cultured hippocampal neurons because provide...
Extracellular recordings indicate that mechanisms control contrast gain of neuronal discharge are found in the retina, thalamus and cortex. In addition, cortex is able to adapt its response function match average local contrast. Here we examine mechanism adaptation by direct intracellular vivo. Both simple (n = 3) complex cells 4) show during recording. For cells, amplitude fluctuations membrane potential induced a drifting grating stimulus follows relation similar lateral geniculate relay...
Abstract The Integrated Stress Response (ISR) attenuates the rate of protein synthesis while inducing expression stress proteins in cells. Various insults activate kinases that phosphorylate GTPase eIF2 leading to inhibition its exchange factor eIF2B. Vanishing White Matter (VWM) is a neurological disease caused by eIF2B mutations that, like phosphorylated eIF2, reduce activity. We show introduction human VWM mutation into mice leads persistent ISR induction central nervous system....
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition milk ejection during nursing 1–8 . Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate levels in new human mothers 9–11 indicating that cries activate hypothalamic neurons. Here we describe neural circuit routing auditory information about vocalizations to mouse We performed vivo electrophysiological recordings photometry from identified...
Abstract The interaction of descending neocortical outputs and subcortical premotor circuits is critical for shaping the skilled movements. Two broad classes motor cortical output projection neurons provide input to many areas: pyramidal tract (PT), which project throughout neuraxis; intratelencephalic (IT), within cortex striatum. It unclear whether these are functionally in series or separable components control signals distributed across distinct neurons. Here we combine large-scale...
Abstract We recently demonstrated that the collaterals of substantia nigra (SN) projection neurons can implement divisive feedback inhibition, or gain control (Brown et al., 2014). While in vivo recordings were consistent with a causal test was lacking. A model nigral microcircuit implies behavioral effects disrupting intranigral inhibition are distinct from previous functional models. To predictions experimentally, we develop chemogenetic approach selectively suppress synaptic release...
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition milk ejection during nursing1-8. Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate levels in new human mothers9-11 indicating that cries activate hypothalamic neurons. Here we describe neural circuit routing auditory information about vocalizations to mouse We performed vivo electrophysiological recordings photometry from identified...
Abstract Motor cortex is a key node in the forebrain circuits that enable flexible control of limb movements. The influence motor on movement execution primarily carried by either pyramidal tract neurons (PT), which project directly to brainstem and spinal cord, or intratelencephalic (IT), within forebrain. logic interplay between these cell types their relative contribution coordination scaling forelimb movements remains unclear. Here we combine large-scale neural recordings across all...