A5027958194- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Neural dynamics and brain function
- Infant Health and Development
- Neurobiology and Insect Physiology Research
- Memory and Neural Mechanisms
- Decision-Making and Behavioral Economics
- Circadian rhythm and melatonin
- Animal Behavior and Reproduction
- Sleep and Wakefulness Research
- Neonatal Respiratory Health Research
- Biochemical Analysis and Sensing Techniques
- Zebrafish Biomedical Research Applications
- Evolutionary Game Theory and Cooperation
- Retinal Development and Disorders
- Shoulder Injury and Treatment
- Astronomical Observations and Instrumentation
- Behavioral Health and Interventions
- Gene Regulatory Network Analysis
- Child and Animal Learning Development
- Robotics and Sensor-Based Localization
- Neurotransmitter Receptor Influence on Behavior
- Photochromic and Fluorescence Chemistry
Johns Hopkins University
2020-2024
Johns Hopkins Medicine
2020-2024
Max Planck Florida Institute for Neuroscience
2017-2024
Allen Institute
2023-2024
Allen Institute for Neural Dynamics
2023-2024
Dartmouth College
2013-2019
Korea Advanced Institute of Science and Technology
2014-2017
Korea National University of Transportation
2012
Abstract Ras and Rho small GTPases are critical for numerous cellular processes including cell division, migration, intercellular communication. Despite extensive efforts to visualize the spatiotemporal activity of these proteins, achieving sensitivity dynamic range necessary in vivo application has been challenging. Here, we present highly sensitive intensiometric GTPase biosensors visualizing multiple single cells vivo. Red-shifted sensors combined with blue light-controllable optogenetic...
Abstract Genetically defined subgroups of inhibitory interneurons are thought to play distinct roles in learning, but heterogeneity within these has limited our understanding the scope and nature their specific contributions. Here we reveal that chandelier cell (ChC), an interneuron type specializes inhibiting axon-initial segment (AIS) pyramidal neurons, establishes cortical microcircuits for organizing neural coding through selective axo-axonic synaptic plasticity. We found organized motor...
Abstract Oxytocin (OXT) is a neuropeptide originating in the paraventricular nucleus (PVN) of hypothalamus, with role influencing various social behaviors. However, pinpointing its actions only during time animals are performing specific behaviors has been difficult to study. Here we developed an optogenetic gene expression system designed selectively label neuronal populations activated by OXT presence blue-light, named “OXTR-iTango2”. The OXTR-iTango2 was capable inducing reporter both...
Stress adversely affects an array of cognitive functions. Although stress-related disorders are often addressed in adulthood, far less is known about how early-life stress (ELS) the developing brain early postnatal periods. Here we show that ELS, induced by maternal separation, leads to synaptic alteration layer 2/3 pyramidal neurons prefrontal cortex (PFC) mice. We find increased excitatory synapse numbers following ELS and this accompanied hyperexcitability PFC-projecting dopamine (DA)...
A fundamental understanding of behavior requires predicting when and what an individual will choose. However, the actual temporal sequential dynamics successive choices made among multiple alternatives remain unclear. In current study, we tested hypothesis that there is a general bursting property in both timing patterns foraging decisions. We conducted experiment which rats chose four different foods over continuous two-week time period. Regarding were made, found bursts rapidly occurring...
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition milk ejection during nursing 1–8 . Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate levels in new human mothers 9–11 indicating that cries activate hypothalamic neurons. Here we describe neural circuit routing auditory information about vocalizations to mouse We performed vivo electrophysiological recordings photometry from identified...
The nucleus accumbens (NAc) shell lies anatomically at a critical intersection within the brain's reward system circuitry, however, its role in voluntary choice behavior remains unclear. Rats with electrolytic lesions NAc were tested novel foraging paradigm. Over continuous two-week period they freely chose among four nutritionally identical but differently flavored food pellets by pressing corresponding levers. We examined lesion's effects on three behavioral dynamics components: motivation...
Animals typically must make a number of successive choices to achieve goal: e.g., eating multiple food items before becoming satiated. However, it is unclear whether choosing the best first or saving for last represents choice strategy maximize overall reward. Specifically, since outcomes can be evaluated prospectively (with future rewards discounted and more immediate preferred) retrospectively prior recent preferred), conditions under which each are used remains unclear. On one hand,...
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition milk ejection during nursing1-8. Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate levels in new human mothers9-11 indicating that cries activate hypothalamic neurons. Here we describe neural circuit routing auditory information about vocalizations to mouse We performed vivo electrophysiological recordings photometry from identified...
Real-life decisions often require a comparison of multi-attribute options with various benefits and costs, the evaluation each option depends partly on other ones in choice set (i.e., context). Although reinforcement learning models have successfully described behavior, it remains unclear how information is taken into account for making context-dependent decision algorithms. Here we develop computational model attention control that includes context effects decisions, linking model. The...
Purpose The purpose of this study was to evaluate whether extracorporeal shock wave therapy (ESWT) is an effective treatment for myofascial pain syndrome (MPS) upper trapezius.Methods Study subject were 20 patients (7 male and 13 female).The evaluated by assessing function using visual analog scale (VAS) pressure threshold (PPT) Constant-Murley (CMS).Statistical analysis used paired T-test know significance probability between pre-test post-test. ResultsThere no statistical in the change...
Background A fundamental understanding of behavior requires predicting when and what an individual will choose. However, the actual temporal sequential dynamics successive choices made among multiple alternatives remain unclear. Methods In current study, we tested hypothesis that there is a general bursting property in both timing patterns foraging decisions. We conducted experiment which rats chose four different foods over continuous two-week time period.
Neural circuits are reorganized with specificity during learning. Genetically-defined subgroups of inhibitory interneurons thought to play distinct roles in learning, but heterogeneity within these has limited our understanding the scope and nature their specific contributions Here we reveal that chandelier cell (ChC), an interneuron type specializes inhibiting axon-initial segment (AIS) pyramidal neurons, establishes cortical microcircuits for organizing neural coding through selective...
Animals navigate environment based on cognitive map built upon spatial cues and desired outcomes. However, how the goal representation stems from information outcomes, its causal role in action control, remain elusive. Here we show that ‘where-to-escape’ relies formulated by shelter experience. Dopamine (DA) neurons ventral tegmental area (VTA) exhibit valence encodings phasic burst stimulations of VTADA sufficiently generate latent memory. Converging DA excitatory inputs VTA hippocampus...