A5053160401- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Infant Health and Development
- Neuroscience of respiration and sleep
- Hearing Loss and Rehabilitation
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Neonatal Respiratory Health Research
- Retinal Development and Disorders
- Cellular transport and secretion
- Animal Vocal Communication and Behavior
- Olfactory and Sensory Function Studies
- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Plant and Biological Electrophysiology Studies
- Pregnancy and preeclampsia studies
- Hearing, Cochlea, Tinnitus, Genetics
- EEG and Brain-Computer Interfaces
- Ion channel regulation and function
- Birth, Development, and Health
- Anesthesia and Neurotoxicity Research
- Electrochemical Analysis and Applications
- Photoreceptor and optogenetics research
New York University
2018-2025
University of Cologne
2023-2025
University Hospital Cologne
2025
University School
2022
Gènes, synapses et cognition
2021
Centre Interdisciplinaire de Recherche en Biologie
2015-2019
Centre National de la Recherche Scientifique
2017-2018
Collège de France
2014-2018
Inserm
2017-2018
Sorbonne Université
2016-2018
Abstract Astrocytes, via excitatory amino-acid transporter type-2 (EAAT2), are the major sink for released glutamate and contribute to set strength timing of synaptic inputs. The conditions required emergence Hebbian plasticity from distributed neural activity remain elusive. Here, we investigate role EAAT2 in expression a physiologically relevant form learning, spike timing-dependent (STDP). We find that transient blockade disrupts temporal contingency plasticity. Indeed, STDP is replaced...
The loss of cerebellar Purkinje cells is a hallmark neurodegenerative movement disorders, but the mechanisms remain enigmatic. We show that endocytic adaptor protein complex 2 (AP-2) crucial for cell survival. Using mouse genetics, viral tracing, calcium imaging, and kinematic analysis, we demonstrate AP-2 μ subunit in leads to early-onset ataxia progressive degeneration. Synaptic dysfunction, marked by an overrepresentation parallel fibers (PFs) over climbing (CFs), precedes loss....
Embryonic development in many species, including case reports humans, can be temporarily halted before implantation during a process called diapause. Facultative diapause occurs under conditions of maternal metabolic stress such as nursing. While molecular mechanisms have been studied, natural inducing factor has yet to identified. Here, we show that oxytocin induces embryonic mice. We gestational delays were triggered nursing or optogenetic stimulation neurons simulating patterns. Mouse...
Modern neurophysiological experiments frequently involve multiple channels separated by very small distances. A unique methodological concern for multiple-electrode is that of capacitive coupling (cross-talk) between channels. Yet the nature cross-talk recording circuit not well known in field, and extent to which it practically affects neurophysiology has never been fully investigated. Here we describe a simple electrical model simultaneous stimulation with two or more experimentally verify...
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition milk ejection during nursing 1–8 . Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate levels in new human mothers 9–11 indicating that cries activate hypothalamic neurons. Here we describe neural circuit routing auditory information about vocalizations to mouse We performed vivo electrophysiological recordings photometry from identified...
Although many details remain unknown, several positive statements can be made about the laminar distribution of primate frontal eye field (FEF) neurons with different physiological properties. Most certainly, pyramidal in deep layer FEF that project to brainstem carry movement and fixation signals but clear evidence also support at least some deep-layer projecting superior colliculus visual responses. Thus, are functionally heterogeneous. Despite useful functional distinctions between...
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition milk ejection during nursing1-8. Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate levels in new human mothers9-11 indicating that cries activate hypothalamic neurons. Here we describe neural circuit routing auditory information about vocalizations to mouse We performed vivo electrophysiological recordings photometry from identified...
Abstract The selective loss of cerebellar Purkinje cells is a hallmark various neurodegenerative movement disorders, yet the precise mechanism driving their degeneration remains enigmatic. Here, we show that endocytic adaptor protein complex 2 (AP-2) essential for survival cells. Employing multidisciplinary approach encompassing mouse genetics, viral tracing, ex vivo calcium imaging, and kinematic analysis, demonstrate mice lacking µ-subunit AP-2 in exhibit early-onset ataxia associated with...
The genesis of the Local Field Potential (LFP) highly depends on electric properties extracellular medium, but such are still subject to a controversy because contradictory measurements. One possibility is that use metal electrodes as current sources in previous studies provides non-physiological results. We tested this by performing impedance measurements conditions close possible physiological conditions. generated single-cell LFPs injecting subthreshold inputs single neurons using...
Infant cries evoke powerful responses in parents 1–4 . To what extent are parental animals innately sensitive to neonatal vocalizations, or might instead learn about key vocal cues for appropriate parenting responses? In mice, naive virgins do not recognize the meaning of pup distress calls, but begin retrieve pups nest following cohousing with a mother and litter 5–8 These isolation calls can be variable, requiring co-caring generalize across features reliable retrieval 9, 10 Here, using...