A5083860545- Muscle activation and electromyography studies
- Zebrafish Biomedical Research Applications
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Neurobiology and Insect Physiology Research
- Axon Guidance and Neuronal Signaling
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Autophagy in Disease and Therapy
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Dermatology and Skin Diseases
- Cellular transport and secretion
- Planarian Biology and Electrostimulation
- Genetics and Neurodevelopmental Disorders
- Retinal Development and Disorders
- Nerve injury and regeneration
- Musicians’ Health and Performance
- Motor Control and Adaptation
- Protein Tyrosine Phosphatases
- Calcium signaling and nucleotide metabolism
- Circular RNAs in diseases
- EEG and Brain-Computer Interfaces
- Angiogenesis and VEGF in Cancer
- Viral-associated cancers and disorders
University Hospital Cologne
2023-2025
University of Cologne
2024-2025
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2024
Salk Institute for Biological Studies
2017-2023
Max Planck Institute of Neurobiology
2010-2014
Max Planck Society
2010-2013
University of Naples Federico II
2008-2010
MRC Laboratory of Molecular Biology
2010
The Epstein–Barr virus (EBV)-encoded latent membrane protein-1 (LMP1), a functional homologue of the tumor necrosis factor receptor family, substantially contributes to EBV's oncogenic potential by activating nuclear factor-κB (NF-κB). miR-155 is an miRNA critical for B-cell maturation and immunoglobulin production in response antigen. We report that expression much higher EBV-immortalized B cells than EBV-negative cells. LMP1, but not LMP2, up-regulated miR-155, when transfected analyzed...
Abstract Dysfunctions in autophagy, a cellular mechanism for breaking down components within lysosomes, often lead to neurodegeneration. The specific mechanisms underlying neuronal vulnerability due autophagy dysfunction remain elusive. Here we show that contributes cerebellar Purkinje cell (PC) survival by safeguarding their glycolytic activity. Outside the conventional housekeeping role, is also involved ATG5-mediated regulation of glucose transporter 2 (GLUT2) levels during maturation....
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding control has grown rapidly thanks new methods for recording and analyzing populations many individual neurons over time. In contrast, current the nervous system's actual output - activation muscle fibers by typically cannot detect electrical events produced during natural behaviors scale poorly across species groups. Here we a novel class electrode devices ('Myomatrix arrays')...
The expression of the RNA-binding factor Fragile X mental retardation protein (FMRP) is disrupted in most common inherited form cognitive deficiency humans. FMRP controls neuronal morphogenesis by mediating translational regulation and localization a large number mRNA targets, these functions are closely associated with transport complexes within neurites microtubule-based motors. However, mechanisms that link to motors regulate its poorly understood. Here we show complexed Bicaudal-D (BicD)...
Abstract Animals change their location in space by means of walking, running, swimming, or flying, a series rhythmic motor behaviours that together are defined as locomotion. Individual types locomotion require unique coordinated pattern muscle contractions can be inferred the joints across body. Implementations recent advancements machine learning (ML), such DeepLabCut and Simi Shape, have automated tracking body posture, even markerless subjects. Despite ML algorithms alleviating effort,...
SUMMARY Neural circuits in the spinal cord are composed of diverse sets interneurons that play crucial roles shaping motor output. Despite progress revealing cellular architecture cord, extent cell type heterogeneity within interneuron populations remains unclear. Here, we present a single-nucleus transcriptomic atlas V1 across postnatal development. We find core molecular taxonomy distinguishing neonatal perdures into adulthood, suggesting conservation function Moreover, identify key role...
Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). Although locomotor CPGs have been extensively characterized, it remains unknown how the neuronal populations composing them interact to generate adaptive rhythms. We explored non-linear cooperation dynamics among three main of ipsilaterally projecting spinal CPG neurons - V1, V2a, V2b in scratch reflex rhythmogenesis. Ablation all subtypes reduced oscillation frequency. Activation excitatory...
The loss of cerebellar Purkinje cells is a hallmark neurodegenerative movement disorders, but the mechanisms remain enigmatic. We show that endocytic adaptor protein complex 2 (AP-2) crucial for cell survival. Using mouse genetics, viral tracing, calcium imaging, and kinematic analysis, we demonstrate AP-2 μ subunit in leads to early-onset ataxia progressive degeneration. Synaptic dysfunction, marked by an overrepresentation parallel fibers (PFs) over climbing (CFs), precedes loss....
The importance of non-coding RNAs (ncRNAs) as fine regulators eukaryotic gene expression has emerged by several studies focusing on microRNAs (miRNAs). miRNAs represent a newly discovered family non coding-RNAs. They are thought to be crucial players human hematopoiesis and related tumorigenesis potential tool detect the early stages cancer. More recently, regulation numerous long ncRNAs been linked cell growth, differentiation cancer although molecular mechanism their function is still...
Axonal branches of the trigeminal ganglion (TG) display characteristic growth and arborization patterns during development. Subsets TG neurons express different receptors for factors, but these are unlikely to explain unique axonal arborizations. Intrinsic modulators may restrict or enhance cellular responses specific ligands thereby contribute development axon patterns. Protein tyrosine phosphatase receptor type O (PTPRO), which is required Eph receptor-dependent retinotectal in chick...
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding control has grown rapidly thanks new methods for recording and analyzing populations many individual neurons over time. In contrast, current the nervous system’s actual output – activation muscle fibers by typically cannot detect electrical events produced during natural behaviors scale poorly across species groups. Here we a novel class electrode devices (“Myomatrix arrays”)...
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding control has grown rapidly thanks new methods for recording and analyzing populations many individual neurons over time. In contrast, current the nervous system's actual output - activation muscle fibers by typically cannot detect electrical events produced during natural behaviors scale poorly across species groups. Here we a novel class electrode devices ("Myomatrix arrays")...
Abstract Dysfunctions in autophagy, a highly conserved cellular mechanism responsible for the degradation of intracellular components within lysosomes, often result neurodegeneration. The neuroprotective effect autophagy varies across neuronal subtypes, and mechanisms selective vulnerability neurons to dysfunction are currently unknown. Utilizing mouse model ATG5 deficiency inhibitory comprehensive approach, including PET imaging, metabolomics, stable-isotope labeling studies, live cell we...
Abstract Innate and goal-directed movements require a high-degree of trunk appendicular muscle coordination to preserve body stability while ensuring the correct execution motor action. The spinal neural circuits underlying postural are finely modulated by propriospinal, sensory descending feedback, yet how distinct neuron populations cooperate control limb remains unclear. Here, we identified microcircuit composed V2 lineage-derived excitatory (V2a) inhibitory (V2b) neurons that together...
Innate and goal-directed movements require a high-degree of trunk appendicular muscle coordination to preserve body stability while ensuring the correct execution motor action. The spinal neural circuits underlying postural are finely modulated by propriospinal, sensory descending feedback, yet how distinct neuron populations cooperate control limb remains unclear. Here, we identified microcircuit composed V2 lineage-derived excitatory (V2a) inhibitory (V2b) neurons that together coordinate...
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding control has grown rapidly thanks new methods for recording and analyzing populations many individual neurons over time. In contrast, current the nervous system’s actual output – activation muscle fibers by typically cannot detect electrical events produced during natural behaviors scale poorly across species groups. Here we a novel class electrode devices (“Myomatrix arrays”)...
Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding control has grown rapidly thanks new methods for recording and analyzing populations many individual neurons over time. In contrast, current the nervous system’s actual output – activation muscle fibers by typically cannot detect electrical events produced during natural behaviors scale poorly across species groups. Here we a novel class electrode devices (‘Myomatrix arrays’)...
Abstract Dysfunctions in autophagy, a cellular mechanism for breaking down components within lysosomes, often lead to neurodegeneration. The specific mechanisms underlying neuronal vulnerability autophagy dysfunction remain elusive. Here, we show that contributes the survival of cerebellar Purkinje cells (PCs) by safeguarding their glycolytic activity. This function is independent its conventional housekeeping role and involves ATG5-mediated regulation glucose transporter 2 (GLUT2) levels...