A5051452931- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Neural dynamics and brain function
- Planarian Biology and Electrostimulation
- MicroRNA in disease regulation
- Muscle activation and electromyography studies
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- RNA regulation and disease
- Systemic Sclerosis and Related Diseases
- Retinal Development and Disorders
- Circular RNAs in diseases
- Immune Cell Function and Interaction
Salk Institute for Biological Studies
2021-2023
University of California, San Diego
2020-2023
Abstract Innate and goal-directed movements require a high-degree of trunk appendicular muscle coordination to preserve body stability while ensuring the correct execution motor action. The spinal neural circuits underlying postural are finely modulated by propriospinal, sensory descending feedback, yet how distinct neuron populations cooperate control limb remains unclear. Here, we identified microcircuit composed V2 lineage-derived excitatory (V2a) inhibitory (V2b) neurons that together...
Innate and goal-directed movements require a high-degree of trunk appendicular muscle coordination to preserve body stability while ensuring the correct execution motor action. The spinal neural circuits underlying postural are finely modulated by propriospinal, sensory descending feedback, yet how distinct neuron populations cooperate control limb remains unclear. Here, we identified microcircuit composed V2 lineage-derived excitatory (V2a) inhibitory (V2b) neurons that together coordinate...
microRNAs (miRNAs) have unique gene regulatory effects in different neuronal subpopulations. Here, we describe a protocol to identify subtype-specific of miRNA murine motor neuron We detail the preparation primary mouse spinal tissue for single cell RNA sequencing and bioinformatics analyses pseudobulk expression data. This applies differential testing approaches target networks heterogeneous subpopulations that cannot otherwise be captured by bulk approaches. For complete details on use...
The Antiphospholipid Syndrome (APS) is a prothrombotic disorder associated with autoantibodies, and used ‘Sapporo criteria’ or revised ‘Sydney for classification. APS may be primary secondary to systemic lupus erythematosus, infectious diseases. Viral infections, especially HCV lead chronic antigenic stimulation, induce autoimmunity antiphospholipid antibodies due molecular mimicking. Such as APL, factor V Leiden mutation also thrombotic events. These two disorders are reported rarely in...
Innate and goal-directed movements require a high-degree of trunk appendicular muscle coordination to preserve body stability while ensuring the correct execution motor action. The spinal neural circuits underlying postural are finely modulated by propriospinal, sensory descending feedback, yet how distinct neuron populations cooperate control limb remains unclear. Here, we identified microcircuit composed V2 lineage-derived excitatory (V2a) inhibitory (V2b) neurons that together coordinate...