A5107336376- Ion channel regulation and function
- Connexins and lens biology
- Trypanosoma species research and implications
- Yersinia bacterium, plague, ectoparasites research
- Supply Chain and Inventory Management
- Nicotinic Acetylcholine Receptors Study
- Cancer, Stress, Anesthesia, and Immune Response
- Consumer Market Behavior and Pricing
- Research on Leishmaniasis Studies
- Erythrocyte Function and Pathophysiology
- Heat shock proteins research
- Insect and Pesticide Research
- Sustainable Supply Chain Management
- Calcium signaling and nucleotide metabolism
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Parasitic Infections and Diagnostics
- Adenosine and Purinergic Signaling
- Marine Invertebrate Physiology and Ecology
University of Antofagasta
2017-2023
Yale University
2023
Pontificia Universidad Javeriana
2021
Significance This work shows that rat and human pannexin1 channels are not intrinsically sensitive to membrane stretch their activation, previously associated with a physiologic increase in cytoplasmic Ca 2+ concentration, results from phosphorylation via CaMKII the amino acid residue S394 located C terminus of pannexin1. posttranslational modification does significantly affect unitary conductance channel but increases permeability lateral tunnels adenosine triphosphate (ATP) permits influx...
Trypanosoma cruzi, the etiological agent of Chagas diseases, invades cardiac tissue causing acute myocarditis and heart electrical disturbances. In T. cruzi invasion, parasite induces [Ca2+]i transients in host cells, an essential phenomenon for invasion. To date, knowledge on mechanism that elicits during infection myocytes has not been fully characterized. Pannexin1 (Panx1) channel are poorly selective channels found all vertebrates serve as a pathway ATP release. this article, we...
Cells of vertebrate and invertebrate organisms express proteins specialized in membrane channel–based cell–cell communication that are absent unicellular organisms. We recently described the prediction some members large-pore channel family kinetoplastids, consisting called unnexins, which share several structural features with innexin pannexin proteins. Here, we demonstrated unnexin1 protein (Unx1) is delivered to cell membrane, displaying a topology four transmembrane domains C N termini...
This paper studies integration between pricing and coordinated inventory decisions for a two-echelon supply chain in competitive environment. To the best of our knowledge, these problems have traditionally been solved separately. Therefore, we aim to support decision-making process by following an integrated approach. First, develop novel mathematical model that coordinates policies one warehouse N retailers determines selling price using multinomial logit (MNL) demand functions. Then, given...
Abstract Large‐pore channels, including those formed by connexin, pannexin, innexin proteins, are part of a broad family plasma membrane channels found in vertebrates and invertebrates, which share topology features. Despite their relevance parasitic diseases such as Chagas malaria, it was unknown whether these large‐pore present unicellular organisms. We identified 14 putative proteins Trypanosomatidae parasites presumptive homologs proteins. All possess the canonical motif family,...