A5075774778- Neuroendocrine regulation and behavior
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Sleep and Wakefulness Research
- Infant Health and Development
- Memory and Neural Mechanisms
- Neonatal Respiratory Health Research
- Primate Behavior and Ecology
- Birth, Development, and Health
- Advanced Neuroimaging Techniques and Applications
- Neural and Behavioral Psychology Studies
- Nicotinic Acetylcholine Receptors Study
- Chromosomal and Genetic Variations
- Hemispheric Asymmetry in Neuroscience
- Pregnancy and preeclampsia studies
- Carbohydrate Chemistry and Synthesis
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Vagus Nerve Stimulation Research
- Insect and Arachnid Ecology and Behavior
- Glycosylation and Glycoproteins Research
New York University
2021-2025
Johns Hopkins University
2020-2024
University School
2023
George Washington University
2016-2018
Embryonic development in many species, including case reports humans, can be temporarily halted before implantation during a process called diapause. Facultative diapause occurs under conditions of maternal metabolic stress such as nursing. While molecular mechanisms have been studied, natural inducing factor has yet to identified. Here, we show that oxytocin induces embryonic mice. We gestational delays were triggered nursing or optogenetic stimulation neurons simulating patterns. Mouse...
Abstract The attachment of a sugar to hydrophobic polyisoprenyl carrier is the first step for all extracellular glycosylation processes. enzymes that perform these reactions, polyisoprenyl-glycosyltransferases (PI-GTs) include dolichol phosphate mannose synthase (DPMS), which generates donor in endoplasmic reticulum. Here we report 3.0Å resolution crystal structure GtrB, glucose-specific PI-GT from Synechocystis , showing tetramer each protomer contributes two helices membrane-spanning...
Abstract Circadian clocks generate rhythms of arousal, but the underlying molecular and cellular mechanisms remain unclear. In Drosophila , clock output molecule WIDE AWAKE (WAKE) labels rhythmic neural networks cyclically regulates sleep arousal. Here, we show, in a male mouse model, that mWAKE/ANKFN1 subpopulation dorsomedial hypothalamus (DMH) neurons involved arousal acts DMH to reduce at night. vivo Ca 2+ imaging reveals elevated mWAKE activity during wakefulness rapid eye movement...
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition milk ejection during nursing 1–8 . Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate levels in new human mothers 9–11 indicating that cries activate hypothalamic neurons. Here we describe neural circuit routing auditory information about vocalizations to mouse We performed vivo electrophysiological recordings photometry from identified...
Abstract Oxytocin is a neuropeptide important for maternal physiology and childcare, including parturition milk ejection during nursing1-8. Suckling triggers oxytocin release, but other sensory cues- specifically infant cries- can elevate levels in new human mothers9-11 indicating that cries activate hypothalamic neurons. Here we describe neural circuit routing auditory information about vocalizations to mouse We performed vivo electrophysiological recordings photometry from identified...
Summary The daily cycling of sleep and arousal states is among the most prominent biological rhythms under circadian control. While much known about core clock 1,2 , how this tunes remains poorly understood 3 . In Drosophila we previously characterized WIDE AWAKE (WAKE), a clock-output molecule that promotes at night 4,5 Here, show function WAKE in regulating circadian-dependent neural excitability conserved mice. mWake + cells are found suprachiasmatic nucleus (SCN) dorsomedial hypothalamus...
SUMMARY Sleep is under homeostatic control, whereby increasing wakefulness generates sleep need and triggers drive. However, the molecular cellular pathways by which encoded are poorly understood. In addition, mechanisms underlying both how when transformed to drive unknown. Here, using ex vivo in imaging, we show Drosophila that astroglial Ca 2+ signaling increases with need. We demonstrate this dependent on a specific L-type channel required for rebound. Thermogenetically astrocytes...
Sleep is regulated by homeostatic sleep drive and the circadian clock. While tremendous progress has been made in elucidating molecular components of core oscillator, output mechanisms which this robust oscillator generates rhythmic behaviour remain poorly understood. At cellular level, growing evidence suggests that subcircuits master pacemaker suprachiasmatic nucleus (SCN) mammals clock network Drosophila regulate distinct aspects sleep. Thus, to identify novel molecules regulating timing...