A5054571568- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Animal Vocal Communication and Behavior
- Adipose Tissue and Metabolism
- Amyotrophic Lateral Sclerosis Research
- Advanced Memory and Neural Computing
- Circadian rhythm and melatonin
- Hormonal Regulation and Hypertension
- Infant Health and Development
- Neuroscience and Music Perception
- Cardiac electrophysiology and arrhythmias
- Hypothalamic control of reproductive hormones
- Cardiomyopathy and Myosin Studies
- Vagus Nerve Stimulation Research
- Animal Nutrition and Physiology
- Transcranial Magnetic Stimulation Studies
- Dementia and Cognitive Impairment Research
- Biochemical Analysis and Sensing Techniques
- Neurological Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Biochemical effects in animals
New York University
2018-2025
Washington University in St. Louis
2025
NYU Langone Health
2020-2024
Seoul National University
2023
Shandong University
2022
Neurosciences Institute
2020
The University of Texas at San Antonio
2014
University of North Carolina at Chapel Hill
2011
Indiana University School of Medicine
2010
Transactivating response region DNA binding protein 43 (TDP-43) pathology is prevalent in dementia, but the cell type-specific effects of TDP-43 are not clear, and therapeutic strategies to alleviate TDP-43-linked cognitive decline lacking. We found that patients with Alzheimer's disease or frontotemporal dementia have aberrant accumulation hippocampal astrocytes. In mouse models, induction widespread hippocampus-targeted astrocytic caused progressive memory loss localized changes antiviral...
Neurons respond to synaptic inputs in cell-type-specific ways. Each neuron type may thus uniquely shared patterns of input. We applied statistically identical barrages artificial four striatal cell types assess differences their responses a realistic input pattern. interneuron fired phase with specific input-frequency component. The fast-spiking relation the gamma-band (and higher) frequencies, low-threshold spike beta-band and cholinergic neurons delta-band frequencies. Low-threshold...
Importance Age, sex, and apolipoprotein E ( APOE ) are the strongest risk factors for late-onset Alzheimer disease (AD). The role of in AD varies with sex ancestry. While association biomarkers also across ancestry, no study has systematically investigated both sex-specific ancestry differences on cerebrospinal fluid (CSF) together, resulting limited insights generalizability. Objective To investigate -ε4 3 core CSF ancestries. Design, Setting, Participants This cohort examined (amyloid...
Psychosocial and environmental factors, including loss of natural reward, contribute to the risk drug abuse. Reward has been modeled in animals by removal from social or sexual contact, transfer enriched impoverished housing, restriction food. We previously showed that food increases unconditioned rewarding effects abused drugs conditioned incentive drug-paired environments. Mechanistic studies provided evidence decreased basal dopamine (DA) transmission, adaptive upregulation signaling...
Germline
Striatal interneurons and spiny projection (SP) neurons are differentially tuned to spectral components of their input. Previous studies showed that spike responses somatostatin/NPY-expressing low threshold (LTS) have broad frequency tuning, setting these cells apart from other striatal GABAergic SP neurons. We investigated the mechanism LTS interneuron spiking resonance its relationship non-spiking membrane impedance resonance, finding abolition did not alter resonance. Because pacemakers...
Abstract Background We determined the clinical presentation and outcomes of Omicron variant severe acute respiratory syndrome coronavirus 2 infection in hemodialysis patients identified risk factors for disease (COVID-19) mortality context high vaccination coverage. Methods This was a retrospective cohort study involving who were vaccinated against COVID-19 during March–September 2022, when predominant, rate high. The proportion people with or evaluated using univariate logistic regression....
Abstract TDP-43 pathology is prevalent in dementia but the cell type-specific effects of are not clear and therapeutic strategies to alleviate TDP-43-linked cognitive decline lacking. We found that patients with Alzheimer’s disease (AD) or frontotemporal (FTD) have aberrant accumulation hippocampal astrocytes. In mouse models, induction widespread hippocampus-targeted astrocytic caused progressive memory loss localized changes antiviral gene expression. These were cell-autonomous correlated...
Abstract We previously reported altered neuronal Ca 2+ dynamics in the motor cortex of 12-month-old JNPL3 tauopathy mice during quiet wakefulness or forced running, with a tau antibody treatment significantly restoring activity profile and decreasing pathological these 1 . Whether functional deficits occur at an early stage if is effective younger needed further investigation. In addition, network firing patterns have not been well studied behaving models. this study, we first performed vivo...
Abstract INTRODUCTION It is unclear how early neuronal deficits occur in tauopathies, if these are associated with changes network activity, and they can be alleviated therapies. METHODS To address this, we performed vivo two‐photon Ca 2+ imaging tauopathy mice at 6 versus 12 months, compared to controls, treated the younger animals a tau antibody. RESULTS Neuronal function was impaired months but did not deteriorate further presumably because cortical burden comparable ages. At neurons were...
Summary Inhibitory interneurons regulate excitability, information flow, and plasticity in neural circuits. synapses are also plastic can be modified by changes experience or activity, often together with to excitatory synapses. However, given the diversity of inhibitory cell types within cerebral cortex, it is unclear if similar for various inputs what functional significance might be. Here we examined spike-timing-dependent from four major subtypes GABAergic cells onto layer 2/3 pyramidal...
Infant cries evoke powerful responses in parents 1–4 . To what extent are parental animals innately sensitive to neonatal vocalizations, or might instead learn about key vocal cues for appropriate parenting responses? In mice, naive virgins do not recognize the meaning of pup distress calls, but begin retrieve pups nest following cohousing with a mother and litter 5–8 These isolation calls can be variable, requiring co-caring generalize across features reliable retrieval 9, 10 Here, using...
TDP-43 pathology is linked to cognitive deficits in diverse neurodegenerative disorders, including frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD). The effects of different cell types, astrocytes, are not clear.In this study, we used postmortem human brain samples, extensive behavioral testing numerous cohorts doubly transgenic mice, gene profiling isolated regions cells, glial-neuronal co-culture assays physiology, biochemical identify...
Background: Deoxycorticosterone (DOC) is an endogenous neurosteroid found in brain and serum, precursor of the GABAergic neuroactive steroid (3a,5a)-3,21-dihydroxypregnan-20-one (tetrahydrodeoxycorticosterone, THDOC) glucocorticoid corticosterone.These steroids are elevated following stress or ethanol administration, contribute to sensitivity, their elevation blunted dependence.Methodology/Principal Findings: To systematically define genetic basis, regulation, behavioral significance DOC...