A5062936567- Systemic Lupus Erythematosus Research
- Retinal and Optic Conditions
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Melanoma and MAPK Pathways
- Drug-Induced Adverse Reactions
- Inflammatory mediators and NSAID effects
- Leprosy Research and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Corneal surgery and disorders
- Cardiomyopathy and Myosin Studies
- Cellular Mechanics and Interactions
- Hernia repair and management
- Mechanical Circulatory Support Devices
- Psychological Well-being and Life Satisfaction
- Ocular Surface and Contact Lens
- Colorectal Cancer Treatments and Studies
- Ocular Diseases and Behçet’s Syndrome
- Child Nutrition and Feeding Issues
- Galectins and Cancer Biology
- Retinal Imaging and Analysis
- Drug-Induced Ocular Toxicity
- Contact Dermatitis and Allergies
- Nail Diseases and Treatments
- Facial Nerve Paralysis Treatment and Research
Icahn School of Medicine at Mount Sinai
2016-2024
Child Health and Development Institute
2016-2024
SUNY Upstate Medical University
2021
Universidad de Navarra
2008-2013
Hospital Clínico Universitario Lozano Blesa
2006
Hospital General de La Rioja
2005
Germline mutations in BRAF cause cardio-facio-cutaneous syndrome (CFCS), whereby 40% of patients develop hypertrophic cardiomyopathy (HCM). As the role RAS/MAPK pathway HCM pathogenesis is unclear, we generated a human induced pluripotent stem cell (hiPSC) model for CFCS from three with activating mutations. By sorting SIRPα and CD90, method to examine hiPSC-derived type-specific phenotypes cellular interactions underpinning HCM. BRAF-mutant SIRPα(+)/CD90(-) cardiomyocytes displayed...
Sex-based differences in the impact of comorbidities on coronavirus disease 2019 (COVID-19) related symptoms remain underexplored due to predominance sex-aggregated data. We aimed examine sex associations between preexisting and COVID-19-related during COVID-19 pandemic Dominican Republic. conducted a cross-sectional study using questionnaire survey Republic September 2021 December 2021. Data demographic factors, comorbidities, self-reported were collected. A multiple logistic regression...
Germline
Systemic Arterial hypertension (AHT) is one of the most frequent diseases in industrialised countries, with an incidence reaching 30%, a figure that rising due to greater life expectancy population. This rise arterial tension causes, or accelerates, changes vascular wall target organs such as kidney, brain, heart and eye. At ocular level, AHT produces lesions retina, choroids optic nerve head; this can include wide range lesions, from slight narrowing severe visual loss ischaemic optical...
A 29-year-old man presented with blurred vision, photophobia, and pain after trauma to his left eye caused by a screwdriver. He had history of moderate myopia (visual acuity, 20/25) undergone uneventful bilateral laser-assisted in situ keratomileusis (LASIK) 10 years previously. On examination, he 180-degree traumatic corneal flap dislocation an inverted tear the temporal cornea (Panel A, fluorescein dye). After repositioning flap, disposable contact lens, used as therapeutic bandage, was...
Context: Ethyl chloride (EC) is a fast-acting vapo-coolant spray that provides rapid, transient, local analgesia for minor invasive procedures. Although the application of EC has decreased, it can be used as cryoanalgesic agent in surgical Objective: Despite widespread use anesthetic, there are few reported cases serious adverse side effects. Material and methods: We report 67-year old otherwise healthy man who underwent excision papilloma on his superior right eyelid by general practitioner...
IntroductionLeprosy is a chronic and systemic infection caused by Mycobacterium leprae. According tothe World Health Organization, the prevalence of leprosy registered at beginning 2008stood 212,802 cases. Thanks to anti-leprosy multidrug therapy number new casesdetected globally has fallen.Lagophthalmos can appear in newly diagnosed lepromatous patients underanti-leprosy therapy. Thus, lagophthalmos continues be sight-threatening evenin cured patients.
RASopathies are rare genetic disorders caused by mutations in genes within the canonical Ras/MAPK signaling pathway, affecting cell growth and differentiation. These syndromes, which include conditions like Noonan syndrome (NS), characterized developmental delays, distinctive facial dysmorphia, a variety of cardiac defects, notably hypertrophic cardiomyopathy (HCM). Despite their prevalence impact, therapeutic options for remain limited. Rigosertib, novel dual PI3K/AKT pathway inhibitor, is...
RESUMENCaso clínico: Hombre de 65 años que había sido tratado con AINE tópico (Ketorolaco).El paciente presentó inyección conjuntival, edema párpados, y dermatitis periorbitaria por eccema alérgico contacto secundario a AINE, un hecho raro en este tipo tratamiento.Discusión: Este es caso raro, ya la aplicación Ketorolaco seguro mayoría los pacientes oftalmológicos.Además, las reacciones adversas
Ocular involvement in rheumatoid arthritis (RA) can arise independently of articular and extraarticular disease1. RA is the most common underlying condition associated with destructive corneal disease2,3. Peripheral ulcerative keratitis (PUK) develops form crescent-shaped stromal inflammation on limbal edge cornea, characterized by local thinning affected area. PUK typically a disease long-standing seropositive, erosive RA, which may have serious ocular complications4. Symptoms signs include...