A5102858372- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Retinal Development and Disorders
- Neuropeptides and Animal Physiology
- Neurogenesis and neuroplasticity mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Maternal Mental Health During Pregnancy and Postpartum
- Effects and risks of endocrine disrupting chemicals
- Child and Adolescent Psychosocial and Emotional Development
- Circadian rhythm and melatonin
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- S100 Proteins and Annexins
- RNA regulation and disease
- Axon Guidance and Neuronal Signaling
- Histone Deacetylase Inhibitors Research
- Phosphodiesterase function and regulation
Hunter College
2016-2025
The Graduate Center, CUNY
2015-2025
City University of New York
2011-2023
SUNY Downstate Health Sciences University
2000-2008
State University of New York
2003-2008
University at Albany, State University of New York
2000
Northwestern University
2000
University of California, Berkeley
1994
Analogous to learning and memory storage, long-term potentiation (LTP) is divided into induction maintenance phases. Testing the hypothesis that mechanism of LTP stores information requires reversing this in vivo finding out whether stored lost. This was not previously possible. Recently however, persistent phosphorylation by atypical protein kinase C isoform, Mzeta (PKMz), has been found maintain late hippocampal slices. Here we show a cell-permeable PKMz inhibitor, injected rat...
Protein kinase M zeta (PKM zeta) is a newly described form of PKC that necessary and sufficient for the maintenance hippocampal long term potentiation (LTP) persistence memory in Drosophila. PKM independent catalytic domain atypical isoform produces effects at synapses because it persistently active, lacking autoinhibition from regulatory zeta. has been thought as proteolytic fragment PKC. Here we report brain new isoform, synthesized mRNA encoding without domain. Multiple zeta-specific...
How long-term memories are stored is a fundamental question in neuroscience. The first molecular mechanism for memory storage the brain was recently identified as persistent action of protein kinase Mzeta (PKMζ), an autonomously active atypical C (PKC) isoform critical maintenance potentiation (LTP). PKMζ maintains aversively conditioned associations, but what general form information encodes unknown. We confirmed specificity zeta inhibitory peptide (ZIP) by disrupting place avoidance with...
Although the maintenance mechanism of late long-term potentiation (LTP) is critical for storage memory, expression synaptic enhancement during late-LTP unknown. The autonomously active protein kinase C isoform, Mζ (PKMζ), a core molecule maintaining late-LTP. Here we show that PKMζ maintains through persistent N -ethylmaleimide-sensitive factor (NSF)/glutamate receptor subunit 2 (GluR2)-dependent trafficking AMPA receptors (AMPARs) to synapse. Intracellular perfusion into CA1 pyramidal cells...
Protein kinase Mζ (PKMζ), an autonomously active atypical PKC isoform, is both necessary and sufficient for enhanced synaptic transmission during long-term potentiation (LTP) maintenance. LTP, however, evolves through several temporal phases, which may be mediated by distinct molecular mechanisms of potentiation. Here, we determined the specific phase LTP maintained PKMζ. Using a selective, cell-permeable ζ-pseudosubstrate inhibitor at concentrations that block produced postsynaptic...
Ramón y Cajal proposed 100 years ago that memory formation requires the growth of nerve cell processes. One-half century later, Hebb suggested presynaptic axons and postsynaptic dendrites consequent to coactivity in these synaptic elements was essential for such information storage. In past 25 years, candidate genes have been implicated learning processes, but it has not demonstrated they fact enhance them. Here, we show genetic overexpression growth-associated protein GAP-43, axonal kinase...
Exposure to Bisphenol-A (BPA), an endocrine disruptor used in plastics, occurs the United States on a daily basis. Recent studies suggest exposure during development causes memory deficits later life; however, ramifications of adulthood are unclear. We examined effects acute BPA administration (40 μg/kg) and synaptic plasticity adult male rats. significantly impaired both visual spatial decreased dendritic spine density pyramidal cells CA1 medial prefrontal cortex (mPFC). Additionally,...
Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile social stress-induced mood-related endophenotypes, we examined behavioral, morphological, and biochemical effects of defeat stress model depression on hippocampal dendritic spines within CA1 stratum radiatum. Adolescent (postnatal day 35) male C57BL/6 mice were subjected to episodes 10 consecutive days....
GluA2-containing AMPA receptors and their association with protein kinase M zeta (PKMζ) post-synaptic density-95 (PSD-95) are important for learning, memory synaptic plasticity processes. Here we investigated these markers in the context of an acute 1h platform stress, which can disrupt spatial retrieval a short-term on object placement task long-term well-learned radial arm maze task. Acute stress increased serum corticosterone elevated expression PKMζ while decreasing GluA2. Using...
Long-term potentiation (LTP) and long-term depression (LTD) are persistent modifications of synaptic strength that have been implicated in learning, memory, neuronal development.Despite their opposing effects, both forms plasticity can be triggered by the activation NMDA receptors.One mechanism proposed for this bidirectional response is specific patterns afferent stimulation producing LTP LTD activate to different degrees a uniform receptor population.A second possibility these separate...
Local dendritic protein synthesis provides a mechanism by which the effects of gene expression can be spatially restricted within synaptodendritic compartments neurons. In present study, we show that long-term potentiation (LTP), induced two strong tetanic trains, produced in isolated CA1 apical dendrites and new is critical for this LTP. LTP also blocked rapamycin, an inhibitor growth-related synthesis, similar to observed intact hippocampal slice. These results increased translation...
Increased physical activity is a common feature of anorexia nervosa (AN). Although high levels are associated with greater risk developing AN, particularly when combined dieting, most individuals who diet and exercise maintain healthy body weight. It unclear why some develop AN while do not. A rodent model resilience vulnerability to would be valuable research. Dopamine, which believed play crucial role in regulates both reward may modulate vulnerability.Adolescent young adult female...
Stress can significantly impact brain function and increase the risk for developing various psychiatric disorders. Many of regions that are implicated in disorders vulnerable to effects stress also involved mediating emotional learning. Emotional learning has been a subject intense investigation past 30 years, with vast majority studies focusing on amygdala its role associative fear However, mechanisms by which affects amygdala-dependent memories remain unclear. Here we review literature...
Background Nearly two-thirds of Alzheimer's disease (AD) patients are women. Therapeutics for women critical to lowering their elevated risk developing this major cause adult dementia. Moreover, targeting epigenetic processes such as histone acetylation that regulate multiple cellular pathways is advantageous given the multifactorial nature AD. Histone takes part in memory consolidation, and its disruption linked Objective Determine whether investigational drug RG2833 has repurposing...
Objectives/Goals: Alzheimer’s disease (AD) has limited treatments and an extremely high rate of clinical trial failure. Through a collaborative effort, Agomelatine (AGO) was identified as having repurposing potential for AD. This study sets out to evaluate the preclinical AGO treatment Methods/Study Population: The TgF344-AD rat model (expresses human mutant “Swedish” amyloid-precursor protein Δ exon 9 presenilin 1) used test AGO’s reduce cognitive deficits neuropathology. chosen due its...
Abstract Hippocampal dendritic spine density rapidly increases following estradiol (E 2 ) treatment, but the types of spines and trafficking synaptic markers have received little investigation. We assessed rapid effects E over time on four (stubby, filopodial, long thin, mushroom) AMPA receptor subunit GluA2 PSD95 tertiary, apical dendrites in CA1. Castrated male rats 20 μg kg −1 or vehicle were sacrificed 30 120 min later. Images Golgi‐Cox impregnated PSD95/GluA2 stained captured under...
Methamphetamine (MA) is a toxic, addictive drug shown to modulate learning and memory, yet the neural mechanisms are not fully understood. We investigated effects of 2 weekly injections MA (30 mg/kg) on working memory using radial 8-arm maze (RAM) across 5 weeks in adolescent-age mice. MA-treated mice show significant improvement performance 1 week following first injection compared saline-injected controls. Following abstinence were re-trained reference version RAM assess cognitive...