A5100721480- Hair Growth and Disorders
- Wound Healing and Treatments
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Skin and Cellular Biology Research
- Genetic Mapping and Diversity in Plants and Animals
- Mesenchymal stem cell research
- Adipose Tissue and Metabolism
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Skin Protection and Aging
- Nerve injury and regeneration
- melanin and skin pigmentation
- Pluripotent Stem Cells Research
- Extracellular vesicles in disease
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- 2D Materials and Applications
Sun Yat-sen University
2017-2025
University of Tennessee Health Science Center
2008-2025
Shaanxi Provincial People's Hospital
2025
Fudan University
2025
Southern Medical University
2014-2024
Nanfang Hospital
2024
Chinese Research Academy of Environmental Sciences
2024
Tongji University
2024
State Key Laboratory of Pollution Control and Resource Reuse
2024
St. Jude Children's Research Hospital
2024
Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments transcriptomic organization diseased brains are limited. In this work, we integrated genotypes RNA sequencing brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, bipolar disorder, as well controls. More than 25% the transcriptome exhibits differential splicing or expression,...
2D black phosphorus (BP) nanomaterials are presented as a delivery platform. The endocytosis pathways and biological activities of PEGylated BP nanosheets in cancer cells revealed for the first time. Finally, triple-response combined therapy strategy is achieved by nanosheets, showing promising enhanced antitumor effect. As service to our authors readers, this journal provides supporting information supplied authors. Such materials peer reviewed may be re-organized online delivery, but not...
As a novel 2D material, black phosphorus (BP) nanosheets are considered as promising candidate for drug delivery platform synergistic chemo/photothermal therapy. However, the intrinsic instability of bare BP poses challenge in its biomedical applications. To date, some strategies have been employed to prevent from rapid ambient degradation. Unfortunately, most these not suitable systems. Here, simple polydopamine modification method is developed enhance stability and photothermal performance...
The lateral flow assay is one of the most convenient analytical techniques for analyzing immune response, but its applicability to precise genetic analyses limited by false-positive signal and tedious inefficient hybridization steps. Here, we introduce CRISPR (clustered regularly interspaced short palindromic repeats) /Cas system into assay, termed CRISPR/Cas9-mediated nucleic acid (CASLFA), address such issues. In this study, CASLFA utilized identify Listeria monocytogenes, genetically...
A nanocarrier system of d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized polydopamine-coated mesoporous silica nanoparticles (NPs) is developed for sustainable and pH-responsive delivery doxorubicin (DOX) as a model drug the treatment drug-resistant nonsmall cell lung cancer. Such are desired particle size, loading, release profile. The surface morphology, charge, chemical properties also successfully characterized by series techniques such transmission electron...
The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by combination of environmental genetic factors associated with several polygenic diseases. In this study we combined next-generation sequencing, mapping, set physiological traits the BXD mouse population to explore explain differences gut its impact on metabolic traits. Molecular profiling revealed quantitative microbial composition among...
The recently reported freezing-based labeling method for constructing DNA-AuNP probes is rapid but still requires thiol modification. Here, we evaluated a poly(A)-tagged DNA sequence using the method, and results demonstrated that approximately 10 A bases at ends are essential. More detailed observations revealed some sequences tend to form secondary structures thus shield exposed bases, resulting in inefficient or failed labeling. However, successful was restored by simply increasing...
Abstract Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF cells, leading to telogen–anagen transition (TAT) around the wound and de novo regeneration, mostly through TNF signalling. Both knockout overexpression attenuate neogenesis wounds, suggesting dose-dependent induction by TNF, which is consistent with TNF-induced AKT signalling vitro . β-catenin...
Abstract In cancer, both histopathologic images and genomic signatures are used for diagnosis, prognosis, subtyping. However, combining with data predicting as well the relationships between them, has rarely been explored. this study, we present an integrative genomics framework constructing a prognostic model clear cell renal carcinoma. We patient from The Cancer Genome Atlas (n = 410), extracting hundreds of cellular morphologic features digitized whole-slide eigengenes functional to...
Low targeting efficiency limits the applications of nanoparticles in cancer therapy. The fact that mesenchymal stem cells (MSC) trapped lung after systemic infusion is a disadvantage for cell therapy purposes. Here, we utilized MSC as cancer-targeted drug delivery vehicles by loading (NP) with anti-cancer drug. showed higher intake capacity than fibroblasts. In addition, predominant trapping both rabbit and monkey. IR-780 dye, fluorescent probe used to represent docetaxel (DTX) NP, delivered
Cultured epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs) were capable of reconstituting functional hair follicles after implantation, while the signaling pathways that regulate neogenic follicle formation are poorly investigated. In this study, we aimed to understand interactions between Epi-SCs SKPs during skin organoid uncover key signal crucial for de novo regeneration.To track their fate transplantation, derived from neonatal C57BL/6 mice labeled with tdTomato, isolated...
The development and optimization of metal-based anticancer drugs with novel cytotoxic mechanisms have emerged as key strategies to overcome chemotherapeutic resistance side effects. Agents that simultaneously induce ferroptosis autophagic death received extensive attention potential modalities for cancer therapy. However, only a limited set or treatment can synergistically tumor cell death. In this work, we designed synthesized four new cycloplatinated (II) complexes harboring an...
Microplastics (MPs) are pervasive pollutants in the natural environment and contribute to increased levels of illness both animals humans. However, specific impacts MPs on skin damage alopecia not yet well understood. In this study, we have examined effects two types polystyrene (pristine aged) hair follicle mice. UV irradiation changed chemical physical properties aged MPs, including functional groups, surface roughness, contact angles. vivo vitro experiments, cell injuries related...
A remarkably diverse set of traits maps to a region on mouse distal chromosome 1 (Chr 1) that corresponds human Chr 1q21-q23. This is highly enriched in quantitative trait loci (QTLs) control neural and behavioral phenotypes, including motor behavior, escape latency, emotionality, seizure susceptibility (Szs1), responses ethanol, caffeine, pentobarbital, haloperidol. also controls the expression large number genes, genes are associated with some classical map (e.g., susceptibility). Here, we...
Genetical genomics is a strategy for mapping gene expression variation to quantitative trait loci (eQTLs). We performed genetical experiment in four functionally distinct but developmentally closely related hematopoietic cell populations isolated from the BXD panel of recombinant inbred mouse strains. This analysis allowed us analyze eQTL robustness/sensitivity across different cellular differentiation states. Although we identified large number (365) "static" eQTLs that were consistently...
A smart nanoplatform which co-delivers doxorubicin and P-gp siRNA exhibited an excellent synergistic effect for targeted multidrug-resistant cancer therapy.
Abstract Wound healing is a dynamic process involving the timely transition of organized phases. However, infected wounds often experience prolonged inflammation due to microbial overload. Thus, addressing viable treatment needs across different stages critical challenge in wound management. Herein, novel core‐shell microneedle (CSMN) patch designed for sequential delivery tannic acid‐magnesium (TA‐Mg) complexes and extracellular vesicles from Lactobacillus druckerii (LDEVs). Upon...