A5081094480- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Genomic variations and chromosomal abnormalities
- Genetic Syndromes and Imprinting
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Tryptophan and brain disorders
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Functional Brain Connectivity Studies
- Chromosomal and Genetic Variations
- Prenatal Screening and Diagnostics
- Gene expression and cancer classification
- Autism Spectrum Disorder Research
- Sepsis Diagnosis and Treatment
- Bipolar Disorder and Treatment
- Family Caregiving in Mental Illness
- Genetic Mapping and Diversity in Plants and Animals
- RNA and protein synthesis mechanisms
- Gene Regulatory Network Analysis
- Energy, Environment, Economic Growth
- Congenital heart defects research
Yale University
2024-2025
Hainan Medical University
2024-2025
Cell and Gene Therapy Catapult
2025
Henan Psychiatric Hospital
2021-2024
Xinxiang Medical University
2021-2024
Chengdu Research Base of Giant Panda Breeding
2021-2024
Massachusetts General Hospital
2022-2024
Broad Institute
2022-2024
Children's Hospital of Fudan University
2024
Central South University
2014-2023
Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments transcriptomic organization diseased brains are limited. In this work, we integrated genotypes RNA sequencing brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, bipolar disorder, as well controls. More than 25% the transcriptome exhibits differential splicing or expression,...
Abstract Inflammation is a natural defence response of the immune system against environmental insult, stress and injury, but hyper- hypo-inflammatory responses can trigger diseases. Accumulating evidence suggests that inflammation involved in multiple psychiatric disorders. Using inflammation-related factors as biomarkers disorders requires proof reproducibility specificity changes different disorders, which remains to be established. We performed cross-disorder study by systematically...
Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet little understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, multiomics datasets into resource comprising >2.8 million nuclei from prefrontal cortex across 388 individuals. For 28 cell types, assessed population-level variation in expression and chromatin families drug targets. We identified >550,000 type-specific...
POU3F2 regulates expression of key genes in postmortem brain tissue from patients with schizophrenia or bipolar disorder.
Cellular heterogeneity in the human brain obscures identification of robust cellular regulatory networks, which is necessary to understand function non-coding elements and impact genetic variation. Here we integrate genome-wide chromosome conformation data from purified neurons glia with transcriptomic enhancer profiles, characterize gene landscape two major cell classes brain. We then leverage cell-type-specific landscapes gain insight into etiology several disorders. find that Alzheimer's...
The long noncoding RNA DGCR5 in the 22q11.2 deletion may regulate expression of certain protein-coding genes that are associated with schizophrenia.
Many psychiatric disorders exhibit sex differences, but the underlying mechanisms remain poorly understood. We analyzed transcriptomics data from 2160 postmortem adult prefrontal cortex brain samples PsychENCODE consortium in a sex-stratified study design. compared of patients with schizophrenia (SCZ), bipolar disorder (BD), and autism spectrum (ASD) control brains individuals without known history disease. found that females SCZ, BD, ASD showed higher burden transcriptomic dysfunction than...
The huanglungbin agent was successfully transmitted from diseased citrus plants to healthy Ponkan mandarin seedlings by fourth and fifth instar nymphs of Diaphorina citri Kuwayama not first third nymphs.The effect number adults on transmission showed that a single adult could transmit the pathogen very efficiently.In serial transmissions adults, minimum latent period 1-2 days, maximum 25 days after acquisition feeding.The infected retained infectivity throughout its life.When newly emerged...
Genetic variants may lead to disease, denoted here by a dimmed letter representing nucleotide. The PsychENCODE Consortium presents research link the effects of genetic variation gene expression in brain.
The relationship between the triglyceride‒glucose (TyG) index and clinical prognosis of septic patients in intensive care units (ICUs) remains unclear. This study aimed to explore correlation TyG 28-day all-cause mortality patients. A retrospective observational cohort was conducted, including 8955 from MIMIC IV 2.2 database. primary outcome mortality. Multivariate logistic regression analysis restricted cubic spline were used assess Subgroup analyses sensitivity performed further validate...
<title>Abstract</title> Combined methylmalonic acidemia and homocystinemia (cblC) is an autosomal recessive disorder characterized by aberrant organic acid metabolism. The c.80A > G mutation in the <italic>MMACHC</italic> gene has been documented numerous studies linked to cblC phenotypes. However, this mutation's pathogenic mechanisms remain elusive, as it not yet validated through functional studies. In a previous study, we developed murine model with Mmachc elucidate intricacies of...
The triglyceride-glucose (TyG) index has emerged as a novel marker for insulin resistance and is commonly observed in patients suffering from sepsis-associated acute kidney injury (SA-AKI). This study explored the correlation between TyG short-term all-cause mortality among SA-AKI patients. We performed retrospective analysis of ICU with using data MIMIC-IV database. primary outcomes were 28-day 90-day mortality. Multivariate Cox proportional hazards regression, restricted cubic spline (RCS)...
<title>Abstract</title> Combined methylmalonic acidemia and homocystinemia (cblC) is an autosomal recessive disorder characterized by aberrant organic acid metabolism. The c.80A > G mutation in the <italic>MMACHC</italic> gene has been documented numerous studies linked to cblC phenotypes. However, this mutation's pathogenic mechanisms remain elusive, as it not yet validated through functional studies. In a previous study, we developed murine model with Mmachc elucidate intricacies of...
We aimed to prove the existence of positional effects in Illumina methylation beadchip data and find an optimal correction method. Three HumanMethylation450, three HumanMethylation27 datasets two EPIC were analyzed. ComBat, linear regression, functional normalization single-sample Noob used for minimizing effects. The corrected results evaluated by four methods. detected 52,988 CpG loci significantly associated with sample positions, 112 remained after ComBat primary dataset. pre-...
Abstract Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, these impairments inadequately addressed by current medications. While novel drug targets schizophrenia depression have emerged from recent large-scale genome-wide association studies (GWAS) of psychiatric disorders, GWAS general ability can suggest potential nootropic repurposing. Here, we (1) meta-analyze results two to further enhance power locus discovery; (2)...
Second generation antipsychotics such as risperidone are first-line pharmacotherapy treatment choices for schizophrenia. However, our ability to reliably predict and monitor reaction is impeded by the lack of relevant biomarkers. As a biomarker susceptibility schizophrenia clozapine response, DNA methylation (DNAm) has been studied, but impact on DNAm not explored in drug-naïve patients. The aim present study was examine changes after short-term antipsychotic therapy first-episode (FES)...
Abstract Single-cell genomics is a powerful tool for studying heterogeneous tissues such as the brain. Yet, little understood about how genetic variants influence cell-level gene expression. Addressing this, we uniformly processed single-nuclei, multi-omics datasets into resource comprising >2.8M nuclei from prefrontal cortex across 388 individuals. For 28 cell types, assessed population-level variation in expression and chromatin families drug targets. We identified >550K...
Abstract Copy number variation (CNV) is of great significance in human evolution and disorders. Through tracing the parent-of-origin de nov o pathogenic CNVs, we are expected to investigate relative contributions germline genomic stability on reproductive health. In our study, short tandem repeat (STR) single nucleotide polymorphism (SNP) were used determine 87 novo CNVs found unrelated patients with intellectual disability (ID), developmental delay (DD) multiple congenital anomalies (MCA)....