A5028991511- Schizophrenia research and treatment
- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- Health, Environment, Cognitive Aging
- Mental Health Research Topics
- Cannabis and Cannabinoid Research
- Bioinformatics and Genomic Networks
- Mental Health Treatment and Access
- Autism Spectrum Disorder Research
- Epigenetics and DNA Methylation
- Obsessive-Compulsive Spectrum Disorders
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Attention Deficit Hyperactivity Disorder
- Tryptophan and brain disorders
- Art Therapy and Mental Health
- Psychiatric care and mental health services
- Psychodrama and Leishmaniasis Studies
- Genetic Mapping and Diversity in Plants and Animals
- Music Therapy and Health
- Occupational Therapy Practice and Research
- Parkinson's Disease Mechanisms and Treatments
National and Kapodistrian University of Athens
2016-2025
Eginition Hospital
2016-2025
University Mental Health Research Institute
2007-2022
Association of the Scientific Medical Societies
2021
401 General Military Hospital of Athens
2019
Kings Health Partners
2017
King's College London
2011-2017
The University of Western Australia
2011-2015
North Metropolitan Health Service
2013-2015
Athens State University
1993-2008
Here, we present a large (n = 107,207) genome-wide association study (GWAS) of general cognitive ability ("g"), further enhanced by combining results with large-scale GWAS educational attainment. We identified 70 independent genomic loci associated ability. Results showed significant enrichment for genes causing Mendelian disorders an intellectual disability phenotype. Competitive pathway analysis implicated the biological processes neurogenesis and synaptic regulation, as well gene targets...
We investigated the existence of a temporal association between age at initiation cannabis use and onset psychotic illness in 997 participants from 2010 Survey High Impact Psychosis (SHIP) Australia. tested for group differences duration premorbid exposure to (DPEC). Analyses were repeated subgroups with schizophrenia-spectrum disorder (SSD), diagnosis lifetime dependence (LCD), comorbid SSD/LCD diagnosis. The was linear significant, F(11, 984) = 13.77, P < .001, even after adjusting...
In 2019, the WPA set up an Expert International Advisory Panel for Early Intervention in Psychosis (EIP) Low- and Middle-Income Countries (LMICs), as part of a presidential initiative1 linked to Action Plan 2020-20232-4. Here we present update on recent activities related that initiative. The has promoted several symposia keynote/plenary lectures at international conferences EIP models LMICs, their clinical effectiveness, cultural contextualization, implementation challenges. These included...
Abstract The tryptophan-metabolizing kynurenine pathway (KP) can be activated by enhanced inflammatory responses and has been implicated in the pathophysiology of schizophrenia. However, there is little evidence for KP dysregulation early course psychotic illness. We aimed to investigate potential immune-mediated hyperactivity individuals with first-episode psychosis (FEP) relationship symptom severity treatment response outcomes. Serum immunoassays were performed measure peripheral levels...
Background: Schizotypal traits are notably prevalent among children diagnosed with Autism Spectrum Disorder (ASD). Both conditions commonly exhibit impairments in executive functions (EF), which encompass &quot;cool&quot; and &quot;hot&quot; processes. The observed deficits these EF domains across ASD schizotypy underscore a compelling need to investigate how their co-occurrence impacts EF. Methods: This study investigated the impact of co-occurring autistic schizotypal on 63...
Schizotypal traits are considered to be clinical and cognitive features of Disorder in children (SDc). These also seen adolescents with high-functioning Autism Spectrum (ASD). This study examines the influence schizotypal (and their se-verity) on capacity ASD manage emotions, develop relationships others adapt school family life. Methods: The 63 (6-12 years old) High Functioning were measured by Melbourne Assessment Schizotypy Kids (MASK). Parents teachers participating completed Child...
Background: Schizotypal traits are notably prevalent among children diagnosed with Autism spectrum disorder (ASD). Both conditions commonly exhibit impairments in executive functions (EF), which encompass cool and hot processes. The observed deficits these EF domains across ASD schizotypy underscore a compelling need to investigate how their co-occurrence impacts EF. Methods: This study investigated the impact of co-occurring autistic schizotypal on 63 ASD, aged 7 12 years. Participants were...
Background: It is unclear whether arts-based social prescribing efficacious for people with mental illness. Methods: Three hundred and eighty two adults, mean age 52 years +/- 14 years, in the community psychiatric diagnoses receiving care as usual (CAU) by their health teams Greece, were referred via a novel Arts on Prescription scheme. Participants randomised either to group-based art intervention (art+CAU) form of regular activities involving theatre, cinema, photography, museum visits,...
Background: It is unclear whether arts-based social prescribing efficacious for people with mental illness. Methods: Three hundred and eighty two adults, mean age 52 years +/- 14 years, in the community psychiatric diagnoses receiving care as usual (CAU) by their health teams Greece, were referred via a novel Arts on Prescription scheme. Participants randomised either to group-based art intervention (art+CAU) form of regular activities involving theatre, cinema, photography, museum visits,...
Introduction Globally, there is limited scientific consensus on the definition of Treatment Resistant Depression (TRD) or Difficult to Treat (DTD) and even greater challenges are being reported with its management. In Greece, last available guidelines depression from 2015 make no reference TRD/DTD This study aims inform TRD DTD propose a pathway for integrated management in context Greek National Health System (NHS). Methods Individual interviews clinical experts based structured interview...
Up-regulation of the complement component 4A (C4A) in brain has been associated with excessive synaptic pruning and increased schizophrenia (SZ) susceptibility. Over-expression C4A observed SZ postmortem tissue, gene encoding for a protein inhibitor activity, CUB Sushi multiple domains 1 (CSMD1) gene, implicated risk cognitive ability. Herein, we examined CSMD1 mRNA expression peripheral blood from antipsychotic-naive individuals first-episode psychosis (FEP; n = 73) mentally healthy...
Although there is some evidence that Theory of Mind (ToM) deficits may be trait markers schizophrenia it not clear yet if ToM are primary deficits, is, to independent in general intellectual abilities and executive function. The aim was examine the illness effect cognitive inhibition, depression on patients with their unaffected parents.We assessed (first-order second-order stories, Revised Eyes Test), inhibition (Stroop Task), ability (Standard Progressive Matrices Test Plus) (N=21) fathers...
Genetic variations in clock-relevant genes have been investigated relation to sleep abnormalities, both healthy populations and mood-disorder patients with inconsistent results. Environmental influences may moderate associations between phenotype. The authors examined the CLOCK 3111T/C polymorphism several variants within PER3 gene their possible interaction stressful life events a group of female volunteers (n = 415). Gene-environment (G × E) interactions main effects were on depressive...
Abstract Broad-based cognitive deficits are an enduring and disabling symptom for many patients with severe mental illness, these impairments inadequately addressed by current medications. While novel drug targets schizophrenia depression have emerged from recent large-scale genome-wide association studies (GWAS) of psychiatric disorders, GWAS general ability can suggest potential nootropic repurposing. Here, we (1) meta-analyze results two to further enhance power locus discovery; (2)...