A5075205011- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Schizophrenia research and treatment
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Genetic Neurodegenerative Diseases
- Memory and Neural Mechanisms
- Nutritional Studies and Diet
- Health Sciences Research and Education
- Neurotransmitter Receptor Influence on Behavior
- Cannabis and Cannabinoid Research
- Bipolar Disorder and Treatment
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Nutrition and Health in Aging
- Muscle activation and electromyography studies
- Neural dynamics and brain function
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Retinal Development and Disorders
- Innovations in Medical Education
Hollywood Private Hospital
2021-2024
The University of Notre Dame Australia
2015-2024
North Metropolitan Health Service
2012-2021
Irish Horseracing Regulatory Board (Ireland)
2019-2020
St. Vincent's University Hospital
2020
University College Dublin
2020
NIHR Clinical Research Network
2018
Government of Western Australia Department of Health
2018
Murphy Oil Corporation (United States)
2017
South Metropolitan Health Service
2012-2015
Electron micrographs of osmium-fixed left ventricles from 200-g female rats were analyzed by stereological techniques. By the use equations developed H. Sitte it was possible to determine volume fractions organelles and absolute membrane areas per unit cell for cellular systems implicated in excitation-contraction coupling. The were: mitochondria 0.34, myofibrils 0.481, T-system 0.012, total sarcotubules 0.035, other 0.13. (μm 2 /μm 3 ) external sarcolemma 0.27, + 1.3. Diads made up 0.08...
Abstract Although apathy is among the most frequent behavioral changes in Parkinson's disease (PD), its diagnosis still problematic, and overlap with depression dementia poorly studied. Aim of study was validate specific criteria to diagnose PD, examine association subsyndromes dementia. A series 164 patients 44 “primary” no 23 Alzheimer's disease, 26 age‐comparable healthy controls underwent a comprehensive psychiatric assessment that included structured interview Apathy Scale. set seven...
A consecutive series of 79 patients with probable Alzheimer's disease were assessed a structured psychiatric evaluation, and diagnoses apathy depression made using standardized criteria. Three-dimensional MRI scans obtained from all patients, images segmented into gray matter, white CSF. White matter hyperintensities edited on images, lobar assignments (frontal, temporal, parietal, occipital) based Talairach coordinates. Patients showed significantly larger volume frontal than without...
We investigated the existence of a temporal association between age at initiation cannabis use and onset psychotic illness in 997 participants from 2010 Survey High Impact Psychosis (SHIP) Australia. tested for group differences duration premorbid exposure to (DPEC). Analyses were repeated subgroups with schizophrenia-spectrum disorder (SSD), diagnosis lifetime dependence (LCD), comorbid SSD/LCD diagnosis. The was linear significant, F(11, 984) = 13.77, P < .001, even after adjusting...
To understand better the organisation of zona incerta thalamus, this study has examined patterns connections that nucleus with various nuclei brainstem. Injections biotinylated dextran or cholera toxin subunit B were made into dorsal raphe, midbrain reticular nucleus, pedunculopontine tegmental periaqueductal grey matter, pontine substantia nigra, superior colliculus, and ventral area Sprague-Dawley rats, their brains processed by using standard tracer-detection methods. In general, our...
In an effort to understand better how the zona incerta may influence neocortical activity, this study has examined patterns of projection that nucleus dorsal thalamus, “gateway” neocortex. To end, Sprague-Dawley rats were anaesthetised with Ketamil (100 mg/kg) and Rompun (10 mg/kg), injections biotinylated dextran or cholera toxin subunit B (CTB) made into various thalamic nuclei, including primary relay (dorsal lateral geniculate, medial ventral posterior), association (lateral dorsal,...
Objective To determine if adiposity in later life increases dementia hazard. Methods Cohort study of 12,047 men aged 65–84 years living Perth, Australia. Adiposity exposures were baseline body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR). We used the Western Australian Data Linkage System (WADLS) to establish presence new cases between 1996 2009 according International Classification Diseases (ICD). Crude adjusted hazard (HR, 95% confidence interval, 95%CI) for...
This study investigated the effect of colloidal bismuth subcitrate and cimetidine on Campylobacter pylori in peptic disease. In 74% 135 patients with disease diagnosed at endoscopy C was detected before treatment. Compared cimetidine, significantly decreased incidence after six weeks treatment (p less than 0.001). group, subsequent healing lesion correlated clearance pylori, unlike group. strongly associated presence histological gastritis, which by
ABSTRACT Background: There is ongoing debate about whether a decline in body mass represents true risk factor for dementia, it phenotypic marker of incipient or perhaps another process that increases dementia risk. This study was designed to determine if changes index (BMI) later life are associated with hazard incident over follow-up period up eight years. Methods: Method followed prospective cohort 4,181 men aged 65–84 years, resident Perth, Australia. The exposure interest change BMI...
Abstract Behavioral variant frontotemporal dementia (bvFTD) has been predominantly considered as a cortical disease, with limited direct investigation of frontal–subcortical connections. We aim to characterize the grey and white matter components frontal–thalamic frontal–striatal circuits in bvFTD. Twenty‐four patients bvFTD 24 healthy controls underwent morphological diffusion imaging. Subcortical structures were manually segmented according published protocols. Probabilistic pathways...
Resting tremor is the most common presenting motor symptom in Parkinson's disease (PD). The supplementary area (SMA) a main target of basal-ganglia-thalamo-cortical circuit and has direct, facilitatory connections with primary cortex (M1), which important for execution voluntary movement. Dopamine potentially modulates SMA M1 activity, both regions have been implicated resting tremor. This study investigated SMA-M1 connectivity individuals PD ON OFF dopamine medication, whether Dual-site...
Absolute rates of immunoreactive atrial natriuretic peptide (ANP) secretion were measured in vitro at 37 degrees C noncontracting preparations combined right and left rat atria constant distending pressures 0 or 5.1 mmHg presence 0.2 mM extracellular Ca2+ concentration [( Ca2+]o), 10 microM ryanodine, either 1 saxitoxin tetrodotoxin. By systematic deletion external Na+, K+, Mg2+, Cl-, HCO3-, reduction [Ca2+]o, by selective ion transport inhibitors, neither net transplasmalemmal fluxes Mg2+...
Parkinson's disease (PD) affects 2–3% of the population over age 65 with loss dopaminergic neurons in substantia nigra impacting functioning basal ganglia-thalamocortical circuits. The precise role played by thalamus is unknown, despite its critical cerebral cortex, and abnormal neuronal activity structure PD. Our objective was to more clearly elucidate how functional connectivity morphology are impacted PD (n = 32) compared Controls 20). To investigate we subdivided into two important...