A5012418429- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Cystic Fibrosis Research Advances
- Intensive Care Unit Cognitive Disorders
- Pediatric health and respiratory diseases
- Long-Term Effects of COVID-19
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Chronic Disease Management Strategies
- Heart Failure Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Dysphagia Assessment and Management
- Pneumonia and Respiratory Infections
- Palliative Care and End-of-Life Issues
- Frailty in Older Adults
- Pulmonary Hypertension Research and Treatments
- Geriatric Care and Nursing Homes
- Ethics in medical practice
- Venous Thromboembolism Diagnosis and Management
- Asthma and respiratory diseases
Northumbria Healthcare NHS Foundation Trust
2016-2025
Newcastle University
2016-2025
North Tyneside General Hospital
2014-2024
Medical Research Council
2021
University of Dundee
2021
Australian National University
2020
University of Newcastle Australia
2002-2017
Auckland City Hospital
2012
Freeman Hospital
2000-2004
Royal Hallamshire Hospital
2001-2003
<h3>Importance</h3> Outcomes after exacerbations of chronic obstructive pulmonary disease (COPD) requiring acute noninvasive ventilation (NIV) are poor and there few treatments to prevent hospital readmission death. <h3>Objective</h3> To investigate the effect home NIV plus oxygen on time or death in patients with persistent hypercapnia an COPD exacerbation. <h3>Design, Setting, Participants</h3> A randomized clinical trial (Paco<sub>2</sub>>53 mm Hg) 2 weeks 4 resolution respiratory...
<h3>Background</h3> Despite exacerbations of chronic obstructive pulmonary disease (COPD) being both common and often fatal, accurate prognostication patients hospitalised with an exacerbation is difficult. For complicated by pneumonia, the CURB-65 prognostic tool frequently used but its use in this population suboptimal. <h3>Methods</h3> Consecutive COPD were recruited. Admission clinical data inhospital death rates recorded. Independent predictors outcome identified logistic regression...
The impact of COVID-19 varies markedly, not only between individual patients but also different populations. We hypothesised that differences in human leukocyte antigen (HLA) genes might influence this variation. Using next generation sequencing, we analysed the class I and II classical HLA 147 individuals European descent experiencing variable clinical outcomes following infection. Forty-nine these were admitted to hospital with severe respiratory disease. They had no significant...
<b><i>Background:</i></b> Noninvasive ventilation (NIV) probably improves survival in ALS, but the magnitude and duration of any improvement quality life (QoL) optimal criteria for initiating treatment are unclear. <b><i>Methods:</i></b> QoL (Short Form-36 [SF-36], Chronic Respiratory Disease Questionnaire, Sleep Apnea Quality Life Index) respiratory function were assessed every 2 months polysomnography 4 22 subjects with ALS. A trial NIV was offered when met one or more predefined criteria:...
<h3>Background</h3> Rates of mortality and readmission are high in patients hospitalised with acute exacerbations chronic obstructive pulmonary disease (AECOPD). In this population, the prognostic value Medical Research Council Dyspnoea Scale (MRCD) is uncertain, an extended MRCD (eMRCD) scale has been proposed to improve its utility. Coexistent pneumonia common and, although CURB-65 prediction tool used, discriminatory not reported. <h3>Methods</h3> Clinical demographic data were collected...
<h3>Background</h3> Hospitalisation due to acute exacerbations of COPD (AECOPD) is common, and subsequent mortality high. The DECAF score was derived for accurate prediction risk stratification inform patient care. We aimed validate the score, internally externally, compare its performance other predictive tools. <h3>Methods</h3> study took place in two hospitals within derivation (internal validation) four additional (external between January 2012 May 2014. Consecutive admissions were...
Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates global burden ECOPD mortality hospital readmission are needed to inform policy makers aid preventive strategies mitigate this burden. The aims present study were explore in-hospital mortality, post-discharge rates after ECOPD-related hospitalisation using an individual patient data meta-analysis (IPDMA) design.
<b><i>Background:</i></b> Most patients with ALS have evidence of respiratory muscle weakness at diagnosis, and death is usually due to failure. Sleep disruption, possibly apneas, hypopneas, orthopnea, or REM-related desaturation, common. The relative impact these factors on quality life has not been established. <b><i>Methods:</i></b> authors recruited 23 subjects probable definite ALS. Quality was assessed using generic specific instruments, strength by measurement vital capacity, maximum...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in death, usually from respiratory failure, within 2-3 years of symptom onset. Non-invasive ventilation (NIV) treatment that when given to patients failure leads improved survival and quality life. Diaphragm pacing (DP), using the NeuRx/4(®) diaphragm system (DPS)™ (Synapse Biomedical, Oberlin, OH, USA), new technique may offer additional or alternative benefits with ALS who are failure. The Pacing Lateral Sclerosis...
<h3>Background</h3> One in three patients hospitalised due to acute exacerbation of COPD (AECOPD) is readmitted within 90 days. No tool has been developed specifically this population predict readmission or death. Clinicians are unable identify at particular risk, yet resources prevent allocated based on clinical judgement. <h3>Methods</h3> In participating hospitals, consecutive admissions with AECOPD were identified by screening wards and reviewing coding records. A 90-day death without...
Background and Objectives: Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. Acute exacerbations (AECOPD) are common often triggered by viral infection. During the COVID-19 pandemic social restrictions, including 'shielding' 'lockdowns', were mandated. Multiple, worldwide studies report reduction in AECOPD admissions during this period. This study aims to assess effect Lockdown on rates admission with severity hospitalised North-East England. Materials...
<h3>Background</h3> In motor neurone disease (MND), respiratory muscle weakness causes substantial morbidity, and death is usually due to failure. Non-invasive ventilation (NIV) improves symptoms, quality of life survival, but previous surveys showed that few patients with MND received NIV. <h3>Methods</h3> A postal survey was conducted the clinical application NIV in among consultant neurologists UK. The results were compared those a similar done 2000. <h3>Findings</h3> Over 12 months, 612...
Previous models of Hospital at Home (HAH) for COPD exacerbation (ECOPD) were limited by the lack a reliable prognostic score to guide patient selection. Approximately 50% hospitalised patients have low mortality risk DECAF, thus are potentially suitable.In non-inferiority randomised controlled trial, 118 admitted with low-risk ECOPD (DECAF 0 or 1) recruited HAH usual care (UC). The primary outcome was health and social costs 90 days.Mean 90-day £1016 lower in HAH, but one-sided 95% CI...
Background In hospitalised patients with exacerbation of Chronic Obstructive Pulmonary Disease, European and British guidelines endorse oxygen target saturations 88%–92%, adjustment to 94%–98% if carbon dioxide levels are normal. We assessed the impact admission saturation level baseline on inpatient mortality. Methods Patients were identified from prospective Dyspnoea, Eosinopenia, Consolidation, Acidaemia Atrial Fibrillation (DECAF) derivation study (December 2008–June 2010) mixed methods...
Background/Objectives: Heart disease is common in COPD, yet it underdiagnosed and undertreated. failure (HF) undiagnosed up to 20% of hospital inpatients. Hospitalised exacerbations COPD (ECOPD) confer high mortality readmission rates, with an elevated temporal cardiac risk. We performed a pilot randomised controlled trial examining the feasibility effect inpatient structured assessment (SCA) diagnose prompt guideline-recommended treatment heart disease. Methods: A total 115 inpatients ECOPD...
This study investigated the effect of colloidal bismuth subcitrate and cimetidine on Campylobacter pylori in peptic disease. In 74% 135 patients with disease diagnosed at endoscopy C was detected before treatment. Compared cimetidine, significantly decreased incidence after six weeks treatment (p less than 0.001). group, subsequent healing lesion correlated clearance pylori, unlike group. strongly associated presence histological gastritis, which by
#### Key points In neuromuscular disease (NMD), respiratory muscle weakness (RMW) is common and death often results from failure. RMW initially causes sleep-related hypoventilation, with sleep disruption. With progression, daytime failure ensues. Bulbar