A5087351248- Health Systems, Economic Evaluations, Quality of Life
- Amyotrophic Lateral Sclerosis Research
- Emergency and Acute Care Studies
- Neurogenetic and Muscular Disorders Research
- Fetal and Pediatric Neurological Disorders
- Respiratory Support and Mechanisms
- Global Cancer Incidence and Screening
- Prenatal Screening and Diagnostics
- Anorectal Disease Treatments and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Statistical Methods in Clinical Trials
- Breast Cancer Treatment Studies
- Cancer survivorship and care
- Pelvic floor disorders treatments
- Diverticular Disease and Complications
- Meta-analysis and systematic reviews
- Asthma and respiratory diseases
- Intestinal and Peritoneal Adhesions
- Abdominal Surgery and Complications
- Primary Care and Health Outcomes
- Interprofessional Education and Collaboration
- Family and Disability Support Research
- Lymphoma Diagnosis and Treatment
- Sepsis Diagnosis and Treatment
University of Sheffield
2016-2025
University of Warwick
2009-2020
University of Florida Health Science Center
2020
University of Florida Health
2020
Cardiff University
2020
North Central Cancer Treatment Group
2020
Bridge University
2020
Royal Marsden NHS Foundation Trust
2020
Brighton and Sussex Medical School
2020
East Midlands Ambulance Service NHS Trust
2020
This article describes updates of the meta-analysis command metan and options that have been added since command's original publication (Bradburn, Deeks, Altman, – an alternative command, Stata Technical Bulletin Reprints, vol. 8, pp. 86–100). These include version 9 graphics with flexible display options, ability to meta-analyze precalculated effect estimates, analyze subgroups by using by() option. Changes output, saved variables, results are also described.
For rare outcomes, meta-analysis of randomized trials may be the only way to obtain reliable evidence effects healthcare interventions. However, many methods are based on large sample approximations, and unsuitable when events rare. Through simulation, we evaluated performance 12 for pooling events, considering estimability, bias, coverage statistical power. Simulations were data sets from three case studies with between five 19 trials, using baseline event rates 0.1 10 per cent risk ratios...
The HTA Programme was
Background Giant cell arteritis (GCA) is a relatively common form of primary systemic vasculitis, which, if left untreated, can lead to permanent sight loss. We compared ultrasound as an alternative diagnostic test with temporal artery biopsy, which may be negative in 9–61% true cases. Objective To compare the clinical effectiveness and cost-effectiveness biopsy diagnosing patients suspected GCA. Design Prospective multicentre cohort study. Setting Secondary care. Participants A total 381...
In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance been poorly defined. We aimed assess whether accuracy and confidence of prenatal diagnosis fetal brain abnormalities is improved with iuMRI clinical impact patient acceptability iuMRI.We did a multicentre, prospective, cohort study in UK, at 16 medicine centres, pregnant women aged years or older whose fetus had abnormality detected by gestational age 18 weeks more, no...
Incidental benign adrenocortical adenomas, adrenal incidentalomas are found in 4.5% of abdominal computed tomography scans, with the incidence increasing to 10% patients older than 70 years age. These frequently show evidence excess cortisol secretion but without overt Cushing's syndrome. The mortality rate is increased This study sought investigate whether have an mortality. was a retrospective, longitudinal cohort study. carried out Endocrine Investigation Unit University Teaching...
BackgroundOptimum surgical intervention for low-grade haemorrhoids is unknown. Haemorrhoidal artery ligation (HAL) has been proposed as an efficacious, safe therapy while rubber band (RBL) a commonly used outpatient treatment. We compared recurrence after HAL versus RBL in patients with grade II–III haemorrhoids.MethodsThis multicentre, open-label, parallel group, randomised controlled trial included from 17 acute UK NHS trusts. screened aged 18 years or older presenting haemorrhoids....
Diabetic peripheral neuropathic pain (DPNP) is common and often distressing. Most guidelines recommend amitriptyline, duloxetine, pregabalin, or gabapentin as initial analgesic treatment for DPNP, but there little comparative evidence on which one best whether they should be combined. We aimed to assess the efficacy tolerability of different combinations first-line drugs DPNP.OPTION-DM was a multicentre, randomised, double-blind, crossover trial in patients with DPNP mean daily numerical...
Tumor development is angiogenesis dependent, and vascular endothelial growth factor (VEGF) a key in this process. We demonstrate that high expression of VEGF mRNA 55 superficial bladder cancers was associated with earlier recurrence (P = 0.001; hazard ratio, 3.09) progression to more invasive phenotype 0.02; 5.33). correlated protein levels tumors (r 0.59, P 0.003) normal 0.65, < 0.05), although the ratio elevated compared 0.004), suggesting posttranscriptional regulation. In study,...
<h3>Aim</h3> To describe procedural aspects and clinical outcomes in a consecutive series of patients whom manual aspiration thrombectomy (MAT) was performed as the first treatment modality with other techniques used only case MAT did not yield recanalization. <h3>Methods</h3> A retrospective review prospectively acquired acute stroke intervention database performed. Primary carried out preference for largest catheter considered to be trackable into target occlusive lesion. The wedged...
<h3>Aim</h3> Acute bronchiolitis is the commonest cause for hospitalisation in infancy. Supportive care remains cornerstone of current management and no other therapy has been shown to influence course disease. It suggested that adding nebulised hypertonic saline usual may shorten duration hospitalisation. To determine whether does have beneficial effects we undertook an open, multi-centre parallel-group, pragmatic RCT ten UK hospitals. <h3>Methods</h3> Infants admitted hospital with a...
Background Obesity is a major challenge for people with schizophrenia. Aims We assessed whether STEPWISE, theory-based, group structured lifestyle education programme could support weight reduction in Method In this randomised controlled trial (study registration: ISRCTN19447796), we recruited adults schizophrenia, schizoaffective disorder or first-episode psychosis from ten mental health organisations England. Participants were randomly allocated to the STEPWISE intervention treatment as...
Objectives We aimed to derive and validate a triage tool, based on clinical assessment alone, for predicting adverse outcome in acutely ill adults with suspected COVID-19 infection. Methods undertook mixed prospective retrospective observational cohort study 70 emergency departments across the United Kingdom (UK). collected presenting data from 22445 people attending between 26 March 2020 28 May 2020. The primary was death or organ support (respiratory, cardiovascular, renal) by record...
BackgroundPeptic ulcers in patients receiving aspirin are associated with Helicobacter pylori infection. We aimed to investigate whether H eradication would protect against aspirin-associated ulcer bleeding.MethodsWe conducted a randomised, double-blind, placebo-controlled trial (Helicobacter Eradication Aspirin Trial [HEAT]) at 1208 primary care centres the UK, using routinely collected clinical data. Eligible were aged 60 years or older who daily dose of 325 mg less (with four more 28-day...
Abstract Background Numerous surgical approaches exist for the treatment of pilonidal disease. Current literature on is poor quality, limiting ability to define optimal intervention. The aim this study was provide real-world data current practice and report patient risk-adjusted outcomes, informing future trial design. Methods This UK-wide multicentre prospective cohort study, including patients (aged over 16 years) who had definitive symptomatic disease, conducted between May 2019 March...
To evaluate the long-term results of high-dose therapy (HDT) in follicular lymphoma, with specific emphasis on prognostic significance polymerase chain reaction (PCR)-detectable Bcl-2/IgH rearrangements.Between June 1985 and October 1995, 99 patients lymphoma received HDT as consolidation second or subsequent remission. Bone marrow was treated vitro anti-B-cell antibodies complement.Sixty-five remained alive, 49 treatment-failure free, a median follow-up 5.5 years (range, 1.5 to 12.5 years)....
Abstract BACKGROUND A review of clinicopathologic features and outcome in women with carcinosarcoma the ovary (also known as malignant mixed mesodermal tumor [MMMT]) compared a group serous adenocarcinoma (SAC) was conducted. METHODS Between 1984 2002, 1568 patients epithelial ovarian carcinoma 70 underwent treatment at Edinburgh Cancer Centre. Analysis performed on 65 MMMT, 746 SAC were selected for comparison. Baseline variables recorded prospectively response to chemotherapy...