A5103042213- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Neurobiology of Language and Bilingualism
- Healthcare cost, quality, practices
- Emergency and Acute Care Studies
- Acute Myocardial Infarction Research
- Health Systems, Economic Evaluations, Quality of Life
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Diabetes Treatment and Management
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Cerebral Palsy and Movement Disorders
- Pediatric Pain Management Techniques
- Child and Adolescent Psychosocial and Emotional Development
- Antibiotic Use and Resistance
- Diabetes Management and Education
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Venous Thromboembolism Diagnosis and Management
- RNA regulation and disease
- Cardiac Imaging and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
- Pneumonia and Respiratory Infections
- Hospital Admissions and Outcomes
- Coronary Artery Anomalies
University of Sheffield
2007-2025
Green Cross International
2021
Children's Hospital of Philadelphia
2019
Post-stroke aphasia might improve over many years with speech and language therapy; however therapy is often less readily available beyond a few months after stroke. We assessed self-managed computerised (CSLT) as means of providing more than patients can access through usual care alone.In this pragmatic, superiority, three-arm, individually randomised, single-blind, parallel group trial, were recruited from 21 departments in the UK. Participants aged 18 or older had been diagnosed...
<h3>Aim</h3> To describe procedural aspects and clinical outcomes in a consecutive series of patients whom manual aspiration thrombectomy (MAT) was performed as the first treatment modality with other techniques used only case MAT did not yield recanalization. <h3>Methods</h3> A retrospective review prospectively acquired acute stroke intervention database performed. Primary carried out preference for largest catheter considered to be trackable into target occlusive lesion. The wedged...
<h3>Aim</h3> Acute bronchiolitis is the commonest cause for hospitalisation in infancy. Supportive care remains cornerstone of current management and no other therapy has been shown to influence course disease. It suggested that adding nebulised hypertonic saline usual may shorten duration hospitalisation. To determine whether does have beneficial effects we undertook an open, multi-centre parallel-group, pragmatic RCT ten UK hospitals. <h3>Methods</h3> Infants admitted hospital with a...
Chest pain due to suspected myocardial infarction (MI) is responsible for many hospital admissions and consumes substantial health care resources. The Randomized Assessment of Treatment using Panel Assay Cardiac markers (RATPAC) trial showed that diagnostic assessment a point-of-care (POC) cardiac biomarker panel consisting CK-MB, myoglobin, troponin increased the proportion patients successfully discharged after emergency department (ED) assessment. In this economic analysis, authors aimed...
Background People with aphasia may improve their communication speech and language therapy many months/years after stroke. However, NHS reduces in availability over time post Objective This trial evaluated the clinical effectiveness cost-effectiveness of self-managed computerised to provide additional therapy. Design A pragmatic, superiority, single-blind, parallel-group, individually randomised (stratified block randomisation, stratified by word-finding severity site) adjunct trial. Setting...
ABSTRACT Aim To explore the views of patients, caregivers, and dental professionals on factors that influence implementation, processes, effectiveness a guided self‐help cognitive behavioural therapy (CBT) intervention, ‘Your teeth, you are in control’ (YTYAIC), CALM trial. Methods Semi‐structured interviews were conducted as part this qualitative component process evaluation, data analysed using framework approach based Consolidated Framework for Implementation Research (CFIR) Five Areas...
<b>Objective</b> To determine whether introducing chest pain unit care reduces emergency admissions without increasing reattendances and over the next 30 days. <b>Design</b> Cluster randomised before after intervention trial. <b>Setting</b> 14 diverse acute hospitals in United Kingdom. <b>Participants</b> Patients attending department with during year started. <b>Intervention</b> Establishment of compared continuation routine care. <b>Main outcome measures</b> Proportion attendances...
Abstract Background Transthyretin amyloidosis, or ATTR, is a progressive and debilitating rare proteopathy generally manifested as either transthyretin amyloid polyneuropathy (ATTR-PN) cardiomyopathy (ATTR-CM). Irrespective of the clinical presentation, affected patients manage chronic life-threatening condition that severely impacts their quality life. Although primary symptoms diagnostic criteria for ATTR are increasingly being discussed in medical literature, due large part by continual...
Objective: To examine the cost-effectiveness of self-managed computerised word finding therapy as an add-on to usual care for people with aphasia post-stroke. Design: Cost-effectiveness modelling over a life-time period, taking UK National Health Service (NHS) and personal social service perspective. Setting: Based on Big CACTUS randomised controlled trial, conducted in 21 NHS speech language departments. Participants: included 278 long-standing Interventions: Computerised plus care; alone;...
Waiting times in emergency departments (EDs) are an important government priority. Although substantial efforts currently being made to reduce waiting times, little attention has been paid the patients' view. We used qualitative methods explore perspectives on and other approaches rationing prioritisation.Face face, depth, interviews (n = 11) explored how patients valued for non-urgent ED care. The framework approach (identifying a thematic through repeated re-reading) was analyse...
Introduction The successful treatment of type 1 diabetes (T1D) requires those affected to employ insulin therapy maintain their blood glucose levels as close normal avoid complications in the long-term. Dose Adjustment For Normal Eating (DAFNE) intervention is a group education course designed help adults with T1D develop and sustain complex self-management skills needed adjust everyday life. It leads improved short term (manifest by falls glycated haemoglobin, HbA1c), reduced rates...
<h3>Background</h3> Chest pain attendances at the emergency department (ED) in UK are continuing to rise. units (CPU) provide nurse-led, protocol-driven care for patients attending ED with acute chest pain. The ESCAPE trial evaluated effectiveness, cost-effectiveness and acceptability of CPU NHS. This paper reports quantitative evaluation acceptability: patient satisfaction routine care. <h3>Methods</h3> study was a cluster-randomised controlled 14 hospitals which seven were allocated...
Barriers to recovering the excess treatment costs associated with health research from local organisations in United Kingdom can increase costs, delay completion of high- quality studies and risk disenfranchising trusts patients participation. The authors demonstrate how process for at a National Health Service (NHS) trust level multicentre study was inconsistent resulted effort cost budget. An innovative example an organisation acting as broker between commissioners researchers facilitated...
May 8, 2019April 9, 2019Free AccessClinical Outcome Assessments in TUBB4A-associated Leukoencephalopathies (P4.6-056)Adeline Vanderver, Julia Kramer-Golinkoff, Brittany Charsar, Omar Sherbini, Zachary Cross, Ann Harrington, Kimberly Kopin, and Elizabeth CrossAuthors Info & AffiliationsApril 2019 issue92 (15_supplement)https://doi.org/10.1212/WNL.92.15_supplement.P4.6-056 Letters to the Editor