A5076195655- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Kidney Stones and Urolithiasis Treatments
- COVID-19 and healthcare impacts
- Pneumonia and Respiratory Infections
- Dementia and Cognitive Impairment Research
- Pediatric Urology and Nephrology Studies
- Trauma and Emergency Care Studies
- Mental Health and Patient Involvement
- Disaster Response and Management
- Geriatric Care and Nursing Homes
- Respiratory Support and Mechanisms
- Chronic Disease Management Strategies
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Primary Care and Health Outcomes
- Radiation Dose and Imaging
- Renal cell carcinoma treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Bladder and Urothelial Cancer Treatments
- Hepatitis C virus research
- Palliative Care and End-of-Life Issues
- Hepatitis B Virus Studies
- Health Policy Implementation Science
- Ureteral procedures and complications
Mission Therapeutics (United Kingdom)
2024
University of Sheffield
2019-2023
Betsi Cadwaladr University Health Board
2023
Western General Hospital
2009-2022
Swansea Bay University Health Board
2021
London South Bank University
2021
Manchester Academic Health Science Centre
2017
University of Manchester
2017
Sheffield Hallam University
2011-2017
University Hospital Leipzig
2015
Objectives We aimed to derive and validate a triage tool, based on clinical assessment alone, for predicting adverse outcome in acutely ill adults with suspected COVID-19 infection. Methods undertook mixed prospective retrospective observational cohort study 70 emergency departments across the United Kingdom (UK). collected presenting data from 22445 people attending between 26 March 2020 28 May 2020. The primary was death or organ support (respiratory, cardiovascular, renal) by record...
Background The WHO and National Institute for Health Care Excellence recommend various triage tools to assist decision-making patients with suspected COVID-19. We aimed compare the accuracy of predicting severe illness in adults presenting ED Methods undertook a mixed prospective retrospective observational cohort study 70 EDs across UK. collected data from people attending COVID-19 used determine results assessment algorithm, Early Warning Score version 2 (NEWS2), CURB-65, CRB-65, Pandemic...
Background Hospital emergency departments play a crucial role in the initial assessment and management of suspected COVID-19 infection. This needs to be guided by studies people presenting with COVID-19, including those admitted discharged, who do not ultimately have confirmed. We aimed characterise patients attending subgroups based on sex, ethnicity test results. Methods findings undertook mixed prospective retrospective observational cohort study 70 across United Kingdom (UK). collected...
Ambulance services need to identify and prioritise patients with sepsis for early hospital assessment. We aimed determine the accuracy of warning scores alongside paramedic diagnostic impression that required urgent treatment.We undertook a retrospective cohort study involving adult emergency medical cases transported Sheffield Teaching Hospitals ED by Yorkshire Service in 2019. used routine ambulance service data calculate 21 categorise impressions as sepsis, infection, non-specific...
Here we present the timeline for those who reach a memory assessment service based on research conducted with 31 people living dementia and 49 carers in one area of UK. The study develops findings earlier work by illuminating other stages journey as events decision points. Two key delay are exposed. Firstly, period from first thinking something may be amiss to point talking someone about it. Secondly, someone, contact healthcare professional (HCP). A third emerged where delays occur once...
There is very often a lengthy delay between first noticing symptoms of dementia and making contact with Health Care Professionals (HCPs). This article identifies influences on the decision to HCPs for time.Qualitative thematic analysis 20 case studies carer experience. Participants were carers people who attended Memory Clinic services.Key themes emerging were: triggers, supports constraints. The draws out social nature engage health care system, considering negotiations that occur areas are...
In response to delays in research for 2009 influenza A/H1N1, 2012 the National Institute Health Research (NIHR), a UK funder, funded portfolio of nine projects.1Simpson CR Beever D Challen K et al.The UK's pandemic portfolio: model future on emerging infections.Lancet Infect Dis. 2019; 19: 295-300Summary Full Text PDF PubMed Scopus (29) Google Scholar These projects were put standby maintenance-only state awaiting activation event new pandemic. The covered key pathways health care, including...
Measurement of post-exertion oxygen saturation has been proposed to assess illness severity in suspected COVID-19 infection. We aimed determine the accuracy post-exertional for predicting adverse outcome COVID-19.We undertook a substudy an observational cohort study across 70 emergency departments during first wave pandemic UK. collected data prospectively, using standardised assessment form, and retrospectively, hospital records, from patients with COVID-19, reviewed records at 30 days...
Tools proposed to triage patient acuity in COVID-19 infection have only been validated hospital populations. We estimated the accuracy of five risk-stratification tools recommended predict severe illness and compared existing clinical decision making a prehospital setting.
<b><i>Introduction:</i></b> The authors of this paper assessed the surgical management and outcome renal cancers when tumor thrombus extended into inferior vena cava (IVC). <b><i>Methods:</i></b> From 2000 to 2015, 46 radical nephrectomies were performed on patients with in IVC. mean age was 60 ± 11 years. Radical nephrectomy thrombectomies a single session. There 18 level-IV, 23 level-III, 5 level-II thrombi. operations using cardiopulmonary...
COVID-19 infected millions of people and increased mortality worldwide. Patients with suspected utilised emergency medical services (EMS) attended departments, resulting in pressures waiting times. Rapid accurate decision-making is required to identify patients at high-risk clinical deterioration following infection, whilst also avoiding unnecessary hospital admissions. Our study aimed develop artificial intelligence models predict adverse outcomes by EMS clinicians.Linked ambulance service...
Many eye movement desensitization and reprocessing (EMDR) therapists moved their practice online during COVID-19. We conducted surveys interviews to understand the implementation acceptability of EMDR therapy. From 17 June 2nd August 2021 an survey was open from Association UK & Ireland International email lists, and, through them, clients. Questions related determinants (for therapists) clients) EMDR. Semi-structured were with a sample therapist respondents provide deeper understanding...
BackgroundThere is an urgent clinical need for evidence-based psychosocial interventions people with mild dementia. We aimed to determine the benefits and cost-effectiveness of Journeying through Dementia (JtD), intervention designed promote wellbeing independence in dementia.MethodsWe did a single-blind, parallel group, individually randomised, phase 3 trial at 13 National Health Service sites across England. People dementia (Mini-Mental State Examination score ≥18) who lived community were...
Fibromyalgia syndrome (FMS) is a long-term condition that affects between 1 and 5% of the general population lies within spectrum medically unexplained symptoms (MUS). FMS can be difficult to diagnose usually done so as diagnosis exclusion. There continuing debate regarding its legitimacy excluding other causes symptoms. It known management MUS, including FMS, receives little attention in medical curricula attitudes towards patients with amongst professionals trainees negative. The purpose...
Objective: To identify the barriers and facilitators to implementation of a complex psychosocial intervention though study exploring experiences participants, carers interventionists during trial. Methods: Individual semi-structured interviews were conducted with their carers, from sample recruiting sites that took part in Journeying through Dementia randomized controlled trial (RCT). Interview data transcribed analysed using framework analysis. Co-researcher analysis workshops also explore...
To assess accuracy of telephone triage in identifying need for emergency care among those with suspected COVID-19 infection and identify factors which affect accuracy. Observational cohort study. Community provided the UK by Yorkshire Ambulance Service NHS Trust (YAS). 40 261 adults who contacted National Health (NHS) 111 services YAS between 18 March 2020 29 June symptoms indicating were linked to Office Statistics death registrations healthcare data collected Digital. Accuracy disposition...
Services are being encouraged to provide postdiagnostic treatment those with dementia but the availability of evidence-based interventions following diagnosis has not kept pace increase in demand. To address this need, Journeying through Dementia (JtD) intervention was created. A randomised controlled trial (RCT), based on a pilot study, is progress. The RCT pragmatic, two-arm, parallel group designed test clinical and cost-effectiveness JtD compared usual care. Recruitment will be NHS...
Background There are few effective interventions for dementia. Aim To determine the clinical effectiveness and cost-effectiveness of an intervention to promote self-management, independence self-efficacy in people with early-stage Objectives undertake a randomised controlled trial Journeying through Dementia compared usual care, conduct internal pilot testing feasibility, assess delivery fidelity qualitative exploration participants’ experiences. Design A pragmatic two-arm individually...
Objective This audit aimed to improve the speed and completeness of delivery treatment urology patients at risk sepsis in hospital. Patients methods were prospectively included if they developed a new-onset systemic inflammatory response syndrome, reviewed by doctor who thought this was due infection prescribed antibiotics. We measured median time antibiotic administration (TTABx) as primary outcome. Factors associated with delays management identified, targeted quality improvement...
Abstract Objectives The World Health Organisation (WHO) and National Institute for Care Excellence (NICE) recommend various triage tools to assist decision-making patients with suspected COVID-19. We aimed estimate the accuracy of predicting severe illness in adults presenting emergency department (ED) COVID-19 infection. Methods undertook a mixed prospective retrospective observational cohort study 70 EDs across United Kingdom (UK). collected data from people attending between 26 March 2020...
To identify clinicopathological or radiological factors that may predict a diagnosis of upper urinary tract urothelial cell carcinoma (UTUC) to inform which patients can proceed directly radical nephroureterectomy (RNU) without the delay for diagnostic ureteroscopy (URS).All consecutive investigated suspected UTUC in high-volume UK centre between 2011 and 2017 were identified through retrospective analysis surgical logbooks prospectively maintained pathology database. Details on clinical...
The RNA methyltransferase METTL1 in complex with the adaptor protein WDR4 is responsible for deposition of N7-methylguanosine at position 46 (m7G46) a subgroup transfer RNAs (tRNAs). m7G46 modification tRNAs mediates their increased structural stability and elevated expression levels, which turn enables translation rates mRNAs enriched codons matching those tRNAs. often found over-expressed cancer tissue, its gene locus frequently amplified tumours. Recent studies have shown that reducing...
Understanding intervention delivery as intended, particularly in complex interventions, should be underpinned by good quality fidelity assessment. We present the findings from a assessment embedded part of trial community-based psychosocial intervention, Journeying through Dementia (JtD). The was designed to equip individuals with knowledge and skills successfully self-manage, maintain independence, live well dementia involves both group individual sessions. methodological challenges...