A5057705931- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Diagnosis and Treatment
- Urologic and reproductive health conditions
- Kidney Stones and Urolithiasis Treatments
- Prostate Cancer Treatment and Research
- Ureteral procedures and complications
- Testicular diseases and treatments
- Genital Health and Disease
- Bladder and Urothelial Cancer Treatments
- Venous Thromboembolism Diagnosis and Management
- Hernia repair and management
- Hormonal and reproductive studies
- Urinary and Genital Oncology Studies
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Urinary Bladder and Prostate Research
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cardiac tumors and thrombi
- Genetic and Kidney Cyst Diseases
- Hormonal Regulation and Hypertension
University of Debrecen
2013-2024
MicroRNAs (miRNAs) play a regulatory role in various human cancers. The roles of hsa-miR-15a-5p, hsa-miR-99b-5p, and hsa-miR-181a-5p have not been fully explored the angiogenesis renal cell carcinoma (RCC).
<b><i>Introduction:</i></b> The authors of this paper assessed the surgical management and outcome renal cancers when tumor thrombus extended into inferior vena cava (IVC). <b><i>Methods:</i></b> From 2000 to 2015, 46 radical nephrectomies were performed on patients with in IVC. mean age was 60 ± 11 years. Radical nephrectomy thrombectomies a single session. There 18 level-IV, 23 level-III, 5 level-II thrombi. operations using cardiopulmonary...
The prognosis of patients with synchronous metastatic renal cell carcinoma (mRCC) is poor. Whereas single-agent tyrosine kinase inhibition (TKI) clearly insufficient, the effects can be enhanced by combinations immune checkpoint inhibitors. Innovative treatment options combining TKI and other immune-stimulating agents could prove beneficial.To evaluate clinical on disease when two doses allogeneic monocyte-derived dendritic cells (ilixadencel) are administrated intratumorally followed...
Objective: To evaluate retrospectively the results and complication, efficacy, safety rates of laparoscopic ureterolithotomy in treatment large, impacted ureteric stones. Materials Methods: Between September 1994 December 2003, 73 patients underwent 75 ureterolithotomies (LUL). Mid- upper-ureteric stones were removed retroperitoneally 69 cases (92%). Lower transperitoneally 6 (8%). There 2 (3%) bilateral LULs one session, 7 (10%) ipsilateral percutaneous nephrolithotomy, (8%) ureteroscopy...
To evaluate our experience and results with endopyelotomy in the pediatric population.Between 1990 2002, we performed percutaneous antegrade under general anesthesia 37 children because of ureteropelvic junction (UPJ) stricture. The youngest patient was 4.5 years oldest 17 at time procedure (mean age 11.5 years). One had bilateral stenosis; two sides were operated on separately. After insertion a 4F ureteral catheter filling collecting system colored contrast material, middle calix punctured...
Abstract BACKGROUND The majority of men will develop symptoms benign prostatic hyperplasia (BPH) after 70 years age. Various studies indicate that antagonists LHRH, such as cetrorelix, exert direct inhibitory effects on BPH mediated by specific LHRH receptors. Our aim was to investigate the mRNA for and receptors expression in specimens human BPH. METHODS (n = 35) 55) investigated RT‐PCR surgical BPH, using primers. characteristics binding sites 20 samples were determined ligand competition...
Recent studies provided evidence that evaluation of thrombin generation identifies patients at thrombotic risk. Thrombin has a central role in hemorrhage control and vascular occlusion its measurement provides new metrics these processes providing sufficient an individual's hemostatic competence response to anticoagulant therapy. The objective the study is assess measure hypercoagulability predisposes venous thromboembolism postoperative period after radical prostatectomy. Pre- (day-1) (hour...
11 Background: Ilixadencel is a cell-based allogeneic off-the-shelf product aimed to prime anti-cancer immune response when injected intratumorally. The present randomized Phase II multicenter trial (MERECA; NCT02432846) evaluated intratumoral ilixadencel administration (2 doses 2 weeks apart) pre-nephrectomy followed by sunitinib post-nephrectomy compared with monotherapy as first-line systemic therapy in patients newly diagnosed synchronous metastatic renal cell carcinoma (mRCC). Methods:...
The genetic profiling of renal tumors has revealed genomic regions commonly affected by structural changes and a general heterogeneity. VHL, PTEN, BAP1 genes are often mutated in tumors. frequency clinical relevance these mutations still being researched. In our study, we investigated the sequencing 24 samples patients with tumors, revealing that VHL was at noticeable (25%). Six showed mutations, one polymorphism (rs779805) detected both heterozygote homozygote forms. PTEN gene mutation...
In this paper, the authors report on a new, modified laparoscopic technique to remove large bladder diverticulum. A 26-year-old male with urinary problem underwent an ultrasound, as well intravenous urography and cystoscopy examinations, which showed The diverticulum was operated upon laparoscopically. extraperitoneal intervention facilitated by balloon placed into new for diverticulumectomy procedure successful operating time 140 minutes. There were no perioperative complications....
<i>Objective:</i> Several authors have investigated the background of process testicular descent, but role appendix testis has not been studied. The human was found to express both estrogen and androgen receptors. We determined compared occurrence appendices intraoperatively in descended undescended testes. <i>Methods:</i> number evaluated retrospectively 208 boys who underwent uni- or bilateral orchiopexy, hydrocele hernia repair visible during operation....
The purpose of this study was to investigate the effects an elevated hydrostatic pressure hydrocele on structural integrity and steroid receptor expression pattern appendix testis in children.Twenty-six testicular appendages were obtained from boys (aged between 13 79 months, mean 40 months) who underwent surgical exploration because or congenital inguinal hernia.The tissue sections stained with hematoxylin-eosin.Immunohistochemistry immunofluorescence laser microscopy performed using...
Venous thromboembolism is a possible fatal complication after pelvic surgery. There lack of trials assessing the effect prophylactic measures in urology. The aim study was to evaluate practice thrombosis prophylaxis Central European country. A questionnaire performed radical prostatectomies, way and number experienced thrombotic events posted all departments urology Hungary. With response rate 59%, 506 prostatectomies were reported. Low molecular weight heparin administered by 100%...
We describe our initial experience with hand-assisted laparoscopic retroperitoneal lymph node dissection for nonseminomatous testicular cancer.Between April 2002 and December 2004, 10 patients tumor were operated on, 6 on the right side 4 left side. Eight in clinical stage I, one patient was IIA, IIB disease. Depending site, a 6-7 cm mid-lower or -upper laparotomy done, HandPort (Smith Nephew, Andover, MA) placed abdominal wall, hand of surgeon inserted into abdomen. Four ports also...
Secondary bladder neoplasms are uncommon and they represent only 2% of all malignant tumors.The authors present a case 59-year-old Caucasian man with primary gastric adenocarcinoma that had been surgically removed 10 years before he developed metastasis. He presented low abdominal pain after without any symptoms. Cystoscopy an computed tomography scan showed tumor. A transurethral resection the tumor was performed. histological examination revealed adenocarcinoma, which turned out to be...
Seminal vesicle cysts can cause sub- or infertility. Minimally invasive techniques have the advantage of preserving vas deferens by treatment symptomatic cases. After reviewing published articles, only a few them presented data on fertility before and after surgery. The authors now report successful two patients with seminal cysts, in which laparoscopic cyst removal resolved symptoms, erectile function. Due to rarity preoperative examinations modalities should focus not relief symptoms but...