A5030810513- Health Systems, Economic Evaluations, Quality of Life
- Global Health Care Issues
- Economic and Environmental Valuation
- Healthcare Policy and Management
- Liver Disease Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Chronic Disease Management Strategies
- Health disparities and outcomes
- Liver Disease and Transplantation
- Geriatric Care and Nursing Homes
- Amyotrophic Lateral Sclerosis Research
- Alcohol Consumption and Health Effects
- Congenital Heart Disease Studies
- Frailty in Older Adults
- Cerebral Palsy and Movement Disorders
- Emergency and Acute Care Studies
- Healthcare cost, quality, practices
- Nicotinic Acetylcholine Receptors Study
- Statistical Methods in Clinical Trials
- Healthcare Systems and Technology
- Advanced Causal Inference Techniques
- Prostate Cancer Treatment and Research
- Family and Disability Support Research
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
University of Sheffield
2015-2024
University of Exeter
2022
Ochsner Health System
2018
Wake Forest University
2001-2017
Hudson Institute
2016
John Wiley & Sons (United States)
2016
Brunel University of London
1999-2015
King's College London
2014
University of Brighton
2014
Brighton and Sussex Medical School
2014
<h3>OBJECTIVES</h3> To assess the impact of myocardial infarction on quality life in four year survivors compared to data from "community norms", and determine factors associated with a poor life. <h3>DESIGN</h3> Cohort study based Nottingham heart attack register. <h3>SETTING</h3> Two district general hospitals serving defined urban/rural population. <h3>SUBJECTS</h3> All patients admitted acute during 1992 alive at median years. <h3>MAIN OUTCOME MEASURES</h3> Short form 36 (SF 36) domain...
Internationally, there is increasing recognition of the need to collect and analyse data on patient safety incidents, facilitate learning develop solutions. The National Patient Safety Agency (NPSA) for England Wales has been capturing incident from acute hospitals since November 2003.This study analyses patterns in reporting incidents all NPSA Reporting Learning System, explores link between rates, hospital characteristics, other quality datasets.Reporting rates System were analysed as...
Background Dementia is one of the most common and serious disorders in later life economic personal cost caring for people with dementia immense. There a need to be able evaluate interventions using cost-effectiveness analyses, but generic preference-based measures typically used measure effectiveness do not work well dementia. Existing dementia-specific can effectively health-related quality their current form cannot directly inform analysis quality-adjusted life-years as effectiveness....
Objectives The Educational Needs Assessment Tool (ENAT) is a self-completed questionnaire, which allows patients with arthritis to prioritise their educational needs. aim of this study was evaluate the effects needs-based patient education on self-efficacy, health outcomes and knowledge in people rheumatoid (RA). Methods Patients RA were enrolled into multicentre, single-blind, parallel-group, pragmatic randomised controlled trial. either intervention group (IG) where completed ENAT,...
The EORTC QLU-C10D is a new multi-attribute utility instrument derived from the widely used cancer-specific quality-of-life (QOL) questionnaire, QLQ-C30. contains ten dimensions (Physical, Role, Social and Emotional Functioning; Pain, Fatigue, Sleep, Appetite, Nausea, Bowel Problems), each with four levels. To be in cost-utility analysis, country-specific valuation sets are required.The aim of this study was to provide Australian weights for QLU-C10D.An online panel quota-sampled ensure...
Alcohol-induced liver damage is associated with oxidative stress, which might be linked to disturbances in antioxidant defense mechanisms. The effect of chronic ethanol consumption on the mitochondrial and cytosolic glutathione/glutathione peroxidase-1 (GSHPx-1) system modification proteins was therefore studied rat.Male Sprague-Dawley rats were fed liquid diets that provided 36% total calories as for at least 31 days. Pair-fed controls received isocaloric substituted maltose-dextrins....
<i>Background:</i> The prevalence of overweight and obesity was examined in African-American Hispanic children compared with white children. <i>Methods:</i> Multivariate analyses were performed on cross-sectional data from the National Survey Children9s Health collected 2003 to 2004. <i>Results:</i> Analyses found that more likely be African American than white, male, live households incomes below 150% Federal poverty level, watch television 3 or hours daily, not have received preventive...
BackgroundGeneric preference-based measures were criticized for being inappropriate in some conditions. One solution is to include “bolt-on” dimensions describing additional specific health problems.ObjectivesThis study aimed develop bolt-on the EuroQol five-dimensional questionnaire (EQ-5D) and assess their impact on state values.MethodsBolt-on developed vision problems, hearing tiredness. Each dimension had three severity levels match EQ-5D. Three “core” EQ-5D states across a range of...
Little is known regarding the epigenetic basis of atherosclerosis. Here we present CD14+ blood monocyte transcriptome and epigenome signatures associated with human The signature includes transcription coactivator, ARID5B, which to form a chromatin derepressor complex histone H3K9Me2-specific demethylase promote adipogenesis smooth muscle development. ARID5B CpG (cg25953130) methylation inversely both expression atherosclerosis, consistent this residing in an enhancer region, based on...
Background: This article presents a valuation study to estimate preference-based index for 5-dimensional health state classification asthma (AQL-5D) derived from the Asthma Quality of Life Questionnaire (AQLQ). Methods: A sample 307 members UK general population valued 99 states selected AQL-5D using time tradeoff technique. Models were estimated predict all possible 3125 defined by AQL-5D, and models compared in terms their ability mean values states. Results: Mean ranged 0.39 0.94 based on...
Aberrant DNA methylation is a recognized feature of human cancers, and folate directly involved in via one-carbon metabolism. Previous reports also suggest that status associated with the natural history papillomavirus (HPV) infection. A cross-sectional study was conducted to test hypothesis aberrant show progressive change across stages cervical pathology from normal cells cancer. Additionally, we postulated gene-specific hypermethylation profile might be used as predictive biomarker cancer...
The majority of health-related quality-of-life instruments are not preference-based measures and so cannot be used within cost utility analysis. Asthma Quality Life Questionnaire (AQLQ) is one such instrument. aim this study was to develop a health state classification that amenable valuation from the AQLQ, being 1st stage in developing condition-specific measure for asthma patients. Rasch models were applied samples responders AQLQ with selecting number items (AQL-5D). Selection evaluation...
We sought to quantify the relationship between body mass index (BMI) and health-related quality (HRQoL) of life, as measured by EQ-5D, whilst controlling for potential confounders. In addition, we hypothesised that certain long-term conditions (LTCs), which being overweight or obese is a known risk factor, may mediate association BMI HRQoL. Hence aim our study was explore HRQoL, first confounders then exploring impact LTCs. used baseline data from South Yorkshire Cohort, cross-sectional...