A5070819440- Amyotrophic Lateral Sclerosis Research
- Family and Disability Support Research
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Psychosomatic Disorders and Their Treatments
- Digital Mental Health Interventions
- Reproductive Health and Contraception
- Ethics in Clinical Research
- Diabetes Management and Research
- Mental Health Treatment and Access
- Parkinson's Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Gynecological conditions and treatments
- Telemedicine and Telehealth Implementation
- Healthcare Policy and Management
- Hospital Admissions and Outcomes
- Health Policy Implementation Science
- Policing Practices and Perceptions
- Primary Care and Health Outcomes
- Dysphagia Assessment and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Treatment and Management
- Mental Health and Psychiatry
- Political Conflict and Governance
University of Sheffield
2015-2024
Clinical Orthopaedics and Related Research
2022-2024
Aintree University Hospital
2012-2019
University of Liverpool
2012-2019
King Abdulaziz Medical City
2014-2016
University of Edinburgh
2015
Harvard University
2014
Leeds Beckett University
1970-2012
Centre for Family Medicine
2012
Institute of Astronomy
1995-2006
<b>Study question</b> How effective is supported computerised cognitive behaviour therapy (cCBT) as an adjunct to usual primary care for adults with depression? <b>Methods</b> This was a pragmatic, multicentre, three arm, parallel randomised controlled trial simple randomisation. Treatment allocation not blinded. Participants were symptoms of depression (score ≥10 on nine item patient health questionnaire, PHQ-9) who receive commercially produced cCBT programme ("Beating the Blues") or free...
Diabetic peripheral neuropathic pain (DPNP) is common and often distressing. Most guidelines recommend amitriptyline, duloxetine, pregabalin, or gabapentin as initial analgesic treatment for DPNP, but there little comparative evidence on which one best whether they should be combined. We aimed to assess the efficacy tolerability of different combinations first-line drugs DPNP.OPTION-DM was a multicentre, randomised, double-blind, crossover trial in patients with DPNP mean daily numerical...
Background Computerised cognitive–behavioural therapy (cCBT) for depression has the potential to be efficient but engagement is poor in primary care trials. Aims We tested benefits of adding telephone support cCBT. Method compared telephone-facilitated cCBT (MoodGYM) ( n = 187) minimally supported 182) a pragmatic randomised trial (trial registration: ISRCTN55310481). Outcomes were severity (Patient Health Questionnaire (PHQ)-9), anxiety (Generalized Anxiety Disorder (GAD)-7) and somatoform...
Background Computerised cognitive behaviour therapy (cCBT) has been developed as an efficient form of delivery with the potential to enhance access psychological care. Independent research is needed which examines both clinical effectiveness and cost-effectiveness cCBT over short longer term. Objectives To compare adjunct usual general practitioner (GP) care against GP alone, for a free-to-use program (MoodGYM; National Institute Mental Health Research, Australian University, Canberra,...
Background Insulin is generally administered to people with type 1 diabetes mellitus (T1DM) using multiple daily injections (MDIs), but can also be delivered infusion pumps. In the UK, pumps are recommended for patients greatest need and adult use less than in comparable countries. Previous trials have been small, of short duration failed control training insulin adjustment. Objective To assess clinical effectiveness cost-effectiveness pump therapy compared MDI adults T1DM, both groups...
An efficient algorithm for adaptive kernel smoothing (AKS) of two-dimensional imaging data has been developed and implemented using the Interactive Data Language (idl). The functional form can be varied (top-hat, Gaussian, etc.) to allow different weighting event counts registered within region. For each individual pixel, increases scale until signal-to-noise ratio (S/N) reaches a pre-set value. Thus, noise is suppressed very efficiently, while at same time real structure, that is, signal...
Abstract Aims To explore health professionals' views about insulin pump therapy [continuous subcutaneous infusion ( CSII )] and the types of individuals they thought would gain greatest clinical benefit from using this treatment. Methods In‐depth interviews with staff n = 18) who delivered Relative Effectiveness Pumps Over MDI Structured Education REPOSE ) trial. Data were analysed thematically. Results Staff perceived pumps as offering a better self‐management tool to some due drip feed...
Abstract Background Group interventions are delivered to groups of people rather than individuals and used in healthcare for mental health recovery, behaviour change, peer support, self-management and/or education. Evaluating group randomised controlled trials (RCTs) presents trialists with a set practical problems, which not present RCTs one-to-one may be immediately obvious. Methods Case-based approach summarising Sheffield unit’s experience the design implementation five interventions. We...
Abstract Police initial training is a newcomer to UK higher education. Other similar professions like teaching and nursing have long-established university partnerships. This paper compares police officer education schemes with teacher nurse The particular focus on the lecturers themselves, ways in which they are positioned between academic professional fields of influence. Three distinct models identified. These demonstrate how inter-institutional relationships significant impact recruits...
The perspectives and experiences of trial staff are increasingly being investigated as these can be used to improve recruitment, adherence protocols support given future staff. We interviewed working on a type 1 diabetes in order aid interpretation findings, inform recommendations for the rollout treatments provide conduct trials. However, our interviews uncovered aspects work erstwhile unrecognised or underreported trials literature, it is which form focus this paper. In-depth were...
Computerised cognitive behaviour therapy (cCBT) is an efficient form of potentially improving access to psychological care. Indirect evidence suggests that the uptake and effectiveness cCBT can be increased if facilitated by telephone, but this not routinely offered in NHS. To compare clinical cost-effectiveness telephone-facilitated free-to-use [e.g. MoodGYM (National Institute for Mental Health Research, Australian National University, Canberra, ACT, Australia)] with minimally supported...
Objectives To assess the long-term cost-effectiveness of insulin pumps and Dose Adjustment for Normal Eating (pumps+DAFNE) compared with multiple daily injections DAFNE (MDI+DAFNE) adults type 1 diabetes mellitus (T1DM) in UK. Methods We undertook a cost–utility analysis using Sheffield Type Diabetes Policy Model data from Relative Effectiveness Pumps over Structured Education (REPOSE) trial to estimate lifetime incidence diabetic complications, intervention-based resource use associated...
Abstract This article examines the philosophical principles underlying police training in England and Wales. An explanation for documented lack of progress changing culture is proposed. It suggested current vogue “National Standards” “Competence Frameworks” based on a discredited technical rationality that models human systems using “machine” metaphors. Such approaches are intellectually impoverished relation to both educational thought wider history ideas. They permit dislocation methods...
Motor neuron disease (MND) is a fatal, progressive neurodegenerative that causes weakening and wasting of limb, bulbar, thoracic abdominal muscles. Clear evidence-based guidance on how psychological distress should be managed in people living with MND (plwMND) lacking. Acceptance Commitment Therapy (ACT) form therapy may particularly suitable for this population. However, to the authors' knowledge, no study date has evaluated ACT plwMND. Consequently, primary aim uncontrolled feasibility was...
Recruitment to clinical trials remains a challenge, particularly in primary care settings. Initial projections of participant recruitment need be as accurate possible order avoid the financial, and ethical costs trial extensions or failures. However, estimation rates is challenging often poorly executed, if attempted at all. We used qualitative methods explore experiences views researchers on planning this setting. Participants had registered accrual UK-based research study between April...
Background: There is a lack of knowledge about what factors may impede or facilitate engagement in psychological interventions people with motor neuron disease (pwMND) and how such can be adapted to best meet the needs this population. Objectives: To explore preferences pwMND respect interventions, adapt for pwMND. Methods: A series semi-structured interviews (n = 22) workshops 3) were conducted 15), informal caregivers 10), MND healthcare professionals 12). These explored concerns that...
Clinical and pathologic evidence for interstitial pulmonary fibrosis occurring in some patients with the Hermansky-Pudlak syndrome is well described literature, but data on immunologic mechanisms operating this form of lung disease have not been published. In case report, we describe bronchoalveolar lavage (BAL) findings a patient syndrome. Recovered alveolar macrophages (AM) contained characteristic ceroidlike material previously specimens. The BAL analysis was similar to that seen...
Greiver, Michelle; White, David; Kaplan, David M.; Katz, Kevin; Moineddin, Rahim; Dolabchian, Edita Author Information
Introduction People with type 1 diabetes (T1DM) require insulin therapy to sustain life, and need optimal glycaemic control prevent diabetic ketoacidosis serious long-term complications. Insulin is generally administered using multiple daily injections but can also be delivered an infusion pump (continuous subcutaneous infusion), a more costly option benefits for some patients. The UK National Institute Health Care Excellence (NICE) recommend the use of pumps patients greatest need, citing...
Motor neuron disease ( MND ), also known as amyotrophic lateral sclerosis, is a neurodegenerative disorder that causes progressive muscle paralysis and typically leads to death within 3 years. As no cure currently available, symptomatic management the mainstay of treatment. An important part this optimizing nutritional intake with evidence may positively affect survival quality life. Health care professionals HCP s) play pivotal role in people (pw ) but, date, their views on psychological...
Abstract STUDY QUESTION What is the clinical-effectiveness and safety of endometrial scratch (ES) procedure compared to no ES, prior usual first time in vitro fertilisation (IVF) treatment? SUMMARY ANSWER ES was safe but did not improve pregnancy outcomes when performed mid-luteal phase IVF cycle, with or without intracytoplasmic sperm injection (ICSI). WHAT IS KNOWN ALREADY an ‘add-on’ treatment that available women undergoing a cycle IVF, ICSI, despite lack evidence support its use....