A5079066516- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Fungal and yeast genetics research
- Cell Adhesion Molecules Research
- Cardiomyopathy and Myosin Studies
- Cellular transport and secretion
- Advanced Fluorescence Microscopy Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ocular Oncology and Treatments
- Force Microscopy Techniques and Applications
- Ubiquitin and proteasome pathways
- Global Health Workforce Issues
- Biotin and Related Studies
- Innovations in Medical Education
- Photosynthetic Processes and Mechanisms
- RNA and protein synthesis mechanisms
- Plant Reproductive Biology
- 3D Printing in Biomedical Research
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Hemoglobin structure and function
- Protist diversity and phylogeny
- Primary Care and Health Outcomes
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
University of Alabama at Birmingham
1996-2024
Washington University in St. Louis
2015-2024
KU Leuven
2024
The Ohio State University
1984-2023
The Ohio State University Wexner Medical Center
2023
Birmingham VA Medical Center
1990-2021
Cleveland Clinic Florida
2019-2020
University of Florida
2020
RELX Group (United States)
2020
University of Alabama
1990-2019
Acute exacerbations adversely affect patients with chronic obstructive pulmonary disease (COPD). Macrolide antibiotics benefit a variety of inflammatory airway diseases.We performed randomized trial to determine whether azithromycin decreased the frequency in participants COPD who had an increased risk but no hearing impairment, resting tachycardia, or apparent prolongation corrected QT interval.A total 1577 subjects were screened; 1142 (72%) randomly assigned receive azithromycin, at dose...
Background: Patients with chronic obstructive pulmonary disease (COPD) frequently develop exacerbations, leading to major clinical and health resource use ramifications. Objective: To prospectively evaluate the effectiveness of a long-acting inhaled anticholinergic bronchodilator, tiotropium, in reducing COPD exacerbations exacerbation-related care utilization. Design: Randomized, double-blind study. Setting: 26 Veterans Affairs medical centers. Patients: 1829 patients moderate severe (mean...
Bursts of actin polymerization in vivo involve the transient appearance free barbed ends. To determine how rapidly ends might appear and long they remain vivo, we studied kinetics capping protein, major end capper, binding to vitro. First, off-rate constant for protein leaving a is slow, predicting half-life capped approximately 30 min. This implies that cells cannot wait spontaneously dissociate from order create However, find phosphatidylinositol 4,5-bisphosphate (PIP2) 4-mono-phosphate...
Cortactin is an actin-binding protein that enriched within the lamellipodia of motile cells and in neuronal growth cones. Here, we report cortactin localized with actin-related (Arp) 2/3 complex at sites actin polymerization lamellipodia. Two distinct sequence motifs contribute to its interaction cortical network: fourth six tandem repeats amino-terminal acidic region (NTA). variants lacking either repeat or NTA failed localize cell periphery. Tandem four was necessary for stably bind...
Radioimmunoassay (RIA) and competitive protein binding (CPB) assays provide dose response curves which show severe nonlinearity the residual (error) variance is non-uniform not normally distributed. Accordingly, several classic "least squares" statistical procedures commonly used for bioassay data are directly applicable. Linearization may be obtained by use of logit transformation, but this increases non-uniformity variance. We have utilized an empirical quality control system in order to...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative analysis of the effect Acanthamoeba profilin on actin filament nucleation and elongationThomas D. Pollard John A. CooperCite this: Biochemistry 1984, 23, 26, 6631–6641Publication Date (Print):December 18, 1984Publication History Published online1 May 2002Published inissue 18 December 1984https://pubs.acs.org/doi/10.1021/bi00321a054https://doi.org/10.1021/bi00321a054research-articleACS PublicationsRequest reuse permissionsArticle...
Retrospective studies have shown that statins decrease the rate and severity of exacerbations, hospitalization, mortality in chronic obstructive pulmonary disease (COPD). We prospectively studied efficacy simvastatin preventing exacerbations a large, multicenter, randomized trial.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid Scintillation Technique for Measuring Carbon-14-Dioxide ActivityJ. M. Passmann, N. S. Radin, and J. A. D. CooperCite this: Anal. Chem. 1956, 28, 4, 484–486Publication Date (Print):April 1, 1956Publication History Published online1 May 2002Published inissue 1 April 1956https://pubs.acs.org/doi/10.1021/ac50161a021https://doi.org/10.1021/ac50161a021research-articleACS PublicationsRequest reuse permissionsArticle...
The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting passage of molecules and microorganisms. Despite this barrier, however, fungal pathogen Cryptococcus neoformans invades brain, causing a meningoencephalitis that is estimated to kill over 600,000 people annually. Cryptococcal infection begins in lung, experimental evidence suggests host phagocytes play role subsequent dissemination, although remains ill defined. Additionally, disparate approaches have been...
Observational studies suggest that beta-blockers may reduce the risk of exacerbations and death in patients with moderate or severe chronic obstructive pulmonary disease (COPD), but these findings have not been confirmed randomized trials.
The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with die, on average, 6 years earlier than without diabetes. We aimed to provide reliable estimates the associations between at diagnosis and all-cause mortality, cause-specific reductions in life expectancy.
During mitosis in budding yeast the nucleus first moves to mother-bud neck and then into neck. Both movements depend on interactions of cytoplasmic microtubules with cortex. We investigated mechanism these living cells using video analysis GFP-labeled wild-type EB1 Arp1 mutants, which are defective second steps, respectively. found that nuclear movement is largely mediated by capture microtubule ends at one cortical region incipient bud site or tip, followed depolymerization. Efficient...