A5100776219- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Respiratory Support and Mechanisms
- Asthma and respiratory diseases
- Obstructive Sleep Apnea Research
- Sleep and related disorders
- Neuroscience of respiration and sleep
- Pulmonary Hypertension Research and Treatments
- Heart Rate Variability and Autonomic Control
- Restless Legs Syndrome Research
- COVID-19 Clinical Research Studies
- Sleep and Wakefulness Research
- Peptidase Inhibition and Analysis
- Pneumonia and Respiratory Infections
- Chronic Disease Management Strategies
- Vitamin D Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV/AIDS oral health manifestations
- Heme Oxygenase-1 and Carbon Monoxide
- Nutrition and Health in Aging
- Cardiovascular and exercise physiology
- Primary Care and Health Outcomes
University of Minnesota
2016-2025
Minneapolis VA Health Care System
2016-2025
Minneapolis VA Medical Center
2010-2025
University of Minnesota System
2007-2024
Pulmonary Associates
2011-2023
Pulmonary and Allergy Associates
2010-2023
Veterans Health Administration
2008-2023
GTx (United States)
2013-2022
Twin Cities Orthopedics
2022
University of Minnesota Medical Center
2008-2021
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (COPD) increase the risk death and drive healthcare costs, but whether they accelerate loss lung function remains controversial. Whether in subjects with mild COPD or similar acute respiratory events smokers without airflow obstruction affect decline is unknown.Objectives: To determine association between (and COPD) change over 5 years follow-up.Methods: We examined data on first 2,000 who returned for a second COPDGene...
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are common, associated with acute inflammation, and may increase subsequent cardiovascular (CVD) risk.Objectives: Determine whether AECOPD events increased risk CVD.Methods: We performed a secondary cohort analysis the SUMMIT (Study to Understand Mortality Morbidity) trial, convenience sample current/former smokers moderate COPD from 1,368 centers in 43 countries. All had CVD or risk. was defined as an...
Observational studies suggest that beta-blockers may reduce the risk of exacerbations and death in patients with moderate or severe chronic obstructive pulmonary disease (COPD), but these findings have not been confirmed randomized trials.
Background The association between chronic obstructive pulmonary disease exacerbations and increased cardiovascular event risk has not been adequately studied in a heterogenous population with both low high risk. Methods Results This post hoc analysis of the IMPACT (Informing Pathway COPD Treatment) trial (N=10 355 symptomatic patients at exacerbations) evaluated time-dependent adverse events special interest (CVAESI) following impact exacerbation history, factors, study treatment on this...
Low blood vitamin D levels have been postulated to be a risk factor for worse lung function, based largely on cross-sectional data. We sought use longitudinal data test the hypothesis that baseline plasma 25-hydroxyvitamin (25(OH)D) is lower in subjects with more rapid function decline, compared those slow decline. conducted nested, matched case-control study Lung Health Study 3 cohort. Cases and controls were continuous smokers respectively, over ~6 yrs of follow-up. 25(OH)D between cases...
Low blood levels of 25-hydroxyvitamin D (25[OH]D) have been associated with a higher risk respiratory infections in general populations and exacerbations lung disease people asthma. We hypothesized that low 25(OH)D patients chronic obstructive pulmonary (COPD) would be an increased acute COPD (AECOPD).To determine if baseline relate to subsequent AECOPD cohort at high for AECOPD.Plasma was measured 973 participants on entry 1-year study designed daily azithromycin decreased the incidence...
Introduction Chronic lung disease is common among people living with HIV (PLWH). We hypothesised that PLWH receiving antiretroviral therapy (ART) have faster function decline than matched controls. Methods performed a prospective cohort study by including ART-treated from the Copenhagen Co-morbidity in Infection Study (n=705) and INSIGHT Strategic Timing of Antiretroviral Treatment Pulmonary Substudy (n=425) frequency population controls General Population (n=2895) 1:3 ratio. Eligible...
A subset of patients with chronic obstructive pulmonary disease (COPD) may respond more favorably to inhaled corticosteroids (ICS), but no simple method is currently utilized predict the presence or absence ICS responses in COPD.We evaluated ability exhaled nitric oxide (FENO) and serum inflammatory markers (C-reactive protein [CRP], interleukin-6 [IL-6], interleukin-8 [IL-8]) independently spirometric COPD.Among 60 ex-smokers severe COPD (mean FEV1 1.07 L, 36% predicted), we conducted a...
Low 25-hydroxyvitamin D (25[OH]D) levels, commonly observed in chronic obstructive pulmonary disease (COPD), are associated with muscle weakness elderly populations, and vitamin supplementation appears to improve strength decrease falls older individuals. We tested the effect of on physical performance patients COPD.Patients were randomized daily cholecalciferol (2000 IU) or placebo for 6 weeks. The primary outcome was 6-week change Short Physical Performance Battery (SPPB) score. Secondary...
Background: Clinical outcomes are worse in patients with COPD and chronic bronchitis. N -acetylcysteine (NAC) is commonly prescribed for such but uncertain clinical benefits. We postulated that oral NAC, at much larger doses than those ordinarily prescribed, would improve a subset of Objective: The aim this study was to determine whether very high-dose NAC respiratory health status Methods: Patients bronchitis were enrolled randomized, controlled, double-blinded trial. received (1,800 mg) or...
Introduction: Poor oral health has been implicated as an independent risk factor for the development of COPD, but few studies have evaluated association between and COPD exacerbations. We aimed to determine if poor is associated with exacerbations and/or worse respiratory health. Methods: performed a case-control study among exacerbators non-exacerbators. Cases (exacerbators) had experienced ≥1 exacerbation in previous 12 months, while controls (non-exacerbators) no 24 months. excluded those...
The impact of respiratory exacerbation on chronic obstructive pulmonary disease (COPD) is well established. effects exacerbations in people with cigarette smoking but normal spirometry are unknown. To assess the association lung function decline and mortality current or former history. We analyzed data from COPDGene participants ≥10 pack-years at enrollment (Visit 1) defined as post-bronchodilator forced expiratory volume 1 second (FEV1)/forced vital capacity (FVC) ≥lower limit (LLN) FEV1...
Objectives The aim of the study was to describe prevalence and correlates chronic obstructive pulmonary disease ( COPD ) in a multicentre international cohort persons living with HIV PLWH ). Methods We performed cross‐sectional analysis adult , naïve treatment, baseline CD4 cell count > 500 cells/μL enrolled Pulmonary Substudy Strategic Timing AntiRetroviral Treatment START trial. collected standardized, quality‐controlled spirometry. defined as forced expiratory volume 1 s:forced vital...
Seasonal nadirs in 25-hydroxyvitamin D (25[OH]D) concentrations overlap with increased incidence and severity of obstructive sleep apnea (OSA) winter. We hypothesized that, because lower 25(OH)D might lead to upper airway muscle dysfunction, low would be associated higher apnea-hypopnea index (AHI), a measure OSA severity.To determine if concentration is greater prevalence OSA, independent established risk factors.Using unconditional logistic regression, we performed cross-sectional analysis...
Initial studies suggest HIV-positive persons may be at increased risk for chronic lung diseases such as obstructive pulmonary disease, but have commonly relied on single-center designs, lacked HIV-negative controls, or assessed function with only spirometry. We tested differences in spirometry and single-breath diffusing capacity carbon monoxide (DLCO) without HIV.Cross-sectional, observational study.Participants were enrolled from the Multicenter AIDS Cohort Study, a longitudinal cohort...
Self-reported sleep quality is poor in persons with human immunodeficiency virus (PWH), but prior studies commonly used nonspecific questionnaires, investigated only single disorders, or lacked (HIV)-negative controls. We addressed these limitations the Pharmacokinetics and Clinical Observations People Over Fifty (POPPY) Sleep Substudy by assessing PWH HIV-negative controls for insomnia, restless legs syndrome (RLS), apnea (SA).Previously enrolled POPPY participants coenrolled this substudy...