A5013701801- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Meningioma and schwannoma management
- Respiratory and Cough-Related Research
- Statistical Methods in Clinical Trials
- Statistical Methods and Bayesian Inference
- Advanced Causal Inference Techniques
- Advanced Radiotherapy Techniques
- Heart Failure Treatment and Management
- Pituitary Gland Disorders and Treatments
- Management of metastatic bone disease
- Neurofibromatosis and Schwannoma Cases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Systems, Economic Evaluations, Quality of Life
- Glioma Diagnosis and Treatment
- Radiation Effects and Dosimetry
- Systemic Sclerosis and Related Diseases
- Statistical Methods and Inference
- Medical Imaging Techniques and Applications
- Eosinophilic Esophagitis
- Trace Elements in Health
- Bone health and osteoporosis research
- Inhalation and Respiratory Drug Delivery
- Vascular Malformations Diagnosis and Treatment
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2024-2025
North Shore University Hospital
2023-2024
Northwell Health
2023
Hartley McMaster (United Kingdom)
2022
AstraZeneca (Brazil)
2020
Boehringer Ingelheim (Philippines)
2020
GlaxoSmithKline (Netherlands)
2014
GlaxoSmithKline (United Kingdom)
2013-2014
SUNY Downstate Health Sciences University
2014
United Medical Center
1988
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are common, associated with acute inflammation, and may increase subsequent cardiovascular (CVD) risk.Objectives: Determine whether AECOPD events increased risk CVD.Methods: We performed a secondary cohort analysis the SUMMIT (Study to Understand Mortality Morbidity) trial, convenience sample current/former smokers moderate COPD from 1,368 centers in 43 countries. All had CVD or risk. was defined as an...
Measurement of sputum or blood eosinophils may allow identification a severe eosinophilic asthma population responsive to mepolizumab.The primary objective was assessment single eosinophil measurement predict future measurements in the following year versus using multiple measurements. In addition, we examined whether useful biomarker for predicting treatment response mepolizumab.Based on data from placebo subjects (n = 155), determined count 150/μl greater at screening remained average...
Background The association between chronic obstructive pulmonary disease exacerbations and increased cardiovascular event risk has not been adequately studied in a heterogenous population with both low high risk. Methods Results This post hoc analysis of the IMPACT (Informing Pathway COPD Treatment) trial (N=10 355 symptomatic patients at exacerbations) evaluated time-dependent adverse events special interest (CVAESI) following impact exacerbation history, factors, study treatment on this...
Abstract Statistical analyses of recurrent event data have typically been based on the missing at random assumption. One implication this is that, if are collected only when patients their randomized treatment, resulting de jure estimator treatment effect corresponds to situation in which adhere regime throughout study. For confirmatory analysis clinical trials, sensitivity required investigate alternative facto estimands that depart from Recent publications described use multiple imputation...
ABSTRACT Making good decisions about whether to commit‐to‐phase 3 clinical trials is challenging. This especially true in oncology because the relationships between registration endpoint, overall survival, and endpoints such as progression‐free survival confirmed objective response are often poorly understood. We present a framework for decision‐making based on three‐endpoint win odds. discuss properties of odds suggest that it can be interpreted, decision‐making, reciprocal an average...
Abstract Background Patients with chronic obstructive pulmonary disease (COPD) are at risk of exacerbations and pneumonia; how the factors interact is unclear. Methods This post-hoc, pooled analysis included studies COPD patients treated inhaled corticosteroid (ICS)/long-acting β 2 agonist (LABA) combinations comparator arms ICS, LABA, and/or placebo. Backward elimination via Cox’s proportional hazards regression modelling evaluated which combination best predicts time to first (a)...
<b>Background:</b> IMPACT is a landmark >10,000 patient study that simplifies care in COPD and prospectively identifies phenotypes/endotypes associated with preferential response to inhaled maintenance treatments. Previous studies have shown relation between ICS-associated reduction the rate of acute exacerbation (AECOPD) baseline blood eosinophil count (BEC). <b>Methods:</b> randomised, double-blind, parallel-group, 52-week, global comparing once-daily fluticasone...
In the IMPACT trial, single-inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) reduced moderate/severe exacerbation rates versus FF/VI or UMEC/VI dual in patients with chronic obstructive pulmonary disease (COPD); however, pneumonia incidence was higher FF-containing arms. As COPD is a growing problem Asia, we compared efficacy and safety of FF/UMEC/VI Asia non-Asia regions.
Discontinuation from randomised treatment is a common intercurrent event in clinical trials. When the target estimand uses policy strategy to deal with this event, data after cessation of relevant estimate and all efforts should be made collect such data. Missing may nevertheless occur due participants withdrawing study assumptions regarding values for that are missing required estimation. A missing-at-random assumption commonly setting, but it not always viewed as appropriate. Another...
ABSTRACT Correctly characterising the dose–response relationship and taking correct dose forward for further study is a critical part of drug development process. We use optimal design theory to compare different designs show that using longitudinal data from all available timepoints in continuous‐time model can substantially increase efficiency estimation compared single timepoint model. give theoretical results calculate gains large class these models. For example, linearly growing Emax...
Abstract BACKGROUND Meningiomas are the most common primary intracranial tumors in adults. Although benign a majority of cases, they have variable clinical course and may recur even after thorough surgical resection. Ki-67, nuclear protein involved cell cycle regulation, has been widely studied as marker cellular proliferation various cancers. Here, we investigate Ki-67 index, predictive meningioma recurrence following METHODS The medical records 451 patients with previously untreated...
Abstract OBJECTIVE Technological advances have allowed stereotactic radiosurgery (SRS) to be administered using fixation with a noninvasive mask, rather than frame. While the use of such masks offers advantages including ability hypofractionate SRS and improved patient comfort, there has been criticism that it eliminates possibility same-day, “wheels in wheels out” SRS. Our study examines feasibility conducting mask fitting treatment on same day versus conventional different-day approach....
<b>Background:</b> Clinical factors may contribute to blood eosinophil count (BEC) variability, leading a question: is one BEC measurement sufficient predict ICS response in COPD? <b>Methods:</b> IMPACT randomised, double-blind, 52-week trial comparing fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) 100/62.5/25µg with FF/VI 100/25µg and UMEC/VI 62.5/25µg. Using negative binomial regression fractional polynomials, this post hoc analysis modelled FF/UMEC/VI vs effect on...