Jeffrey L. Curtis
A5052110481- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Respiratory and Cough-Related Research
- Immune Response and Inflammation
- Gut microbiota and health
- Lung Cancer Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Pulmonary Hypertension Research and Treatments
- Leprosy Research and Treatment
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Mycobacterium research and diagnosis
- Phagocytosis and Immune Regulation
- Inhalation and Respiratory Drug Delivery
- Immune cells in cancer
- Genetic Associations and Epidemiology
- Cell Adhesion Molecules Research
- Nail Diseases and Treatments
- Pneumonia and Respiratory Infections
University of Michigan–Ann Arbor
2016-2025
Michigan Medicine
2016-2025
VA Ann Arbor Healthcare System
2016-2025
Michigan United
2011-2025
Pulmonary and Critical Care Associates
2010-2024
University of Alabama at Birmingham
2024
Institute of Immunology
2008-2023
Veterans Health Administration
1999-2023
United States Department of Veterans Affairs
1994-2022
University of Maryland, Baltimore
2020
Acute exacerbations adversely affect patients with chronic obstructive pulmonary disease (COPD). Macrolide antibiotics benefit a variety of inflammatory airway diseases.We performed randomized trial to determine whether azithromycin decreased the frequency in participants COPD who had an increased risk but no hearing impairment, resting tachycardia, or apparent prolongation corrected QT interval.A total 1577 subjects were screened; 1142 (72%) randomly assigned receive azithromycin, at dose...
Significant heterogeneity of clinical presentation and disease progression exists within chronic obstructive pulmonary (COPD). Although FEV(1) inadequately describes this heterogeneity, a clear alternative has not emerged. The goal phenotyping is to identify patient groups with unique prognostic or therapeutic characteristics, but significant variation confusion surrounds use the term "phenotype" in COPD. Phenotype classically refers any observable characteristic an organism, up until now,...
Although culture-independent techniques have shown that the lungs are not sterile, little is known about lung microbiome in chronic obstructive pulmonary disease (COPD). We used pyrosequencing of 16S amplicons to analyze two ways: first, using bronchoalveolar lavage (BAL) sample distal bronchi and air-spaces; second, by examining multiple discrete tissue sites six subjects removed at time transplantation. performed BAL on three never-smokers (NS) with normal spirometry, seven smokers...
Rationale: Results from 16S rDNA-encoding gene sequence–based, culture-independent techniques have led to conflicting conclusions about the composition of lower respiratory tract microbiome.Objectives: To compare microbiome upper and in healthy HIV-uninfected nonsmokers smokers a multicenter cohort.Methods: Participants were without significant comorbidities. Oral washes bronchoscopic alveolar lavages collected standardized manner. Sequence analysis bacterial rRNA-encoding genes was...
No studies have examined the relationships between bacterial communities along sites of upper aerodigestive tract an individual subject. Our objective was to perform intrasubject and intersite analysis determine contributions two mucosal (mouth nose) as source for microbiome lower (lungs stomach). Oral wash, bronchoalveolar lavage (BAL) fluid, nasal swab, gastric aspirate samples were collected from 28 healthy subjects. Extensive controls serial BAL fluid demonstrated that sampling lungs by...
As increasingly powerful techniques emerge for machine tagging multimedia content, it becomes ever more important to standardize the underlying vocabularies. Doing so provides interoperability and lets community focus ongoing research on a well-defined set of semantics. This paper describes collaborative effort researchers, library scientists, end users develop large standardized taxonomy describing broadcast news video. The large-scale concept ontology (LSCOM) is first its kind designed...
Currently, the diagnosis of chronic obstructive pulmonary disease (COPD) requires a ratio forced expiratory volume in 1 second (FEV1) to vital capacity (FVC) less than 0.70 as assessed by spirometry after bronchodilator use. However, many smokers who do not meet this definition have respiratory symptoms.
The lung microbiome is spatially heterogeneous in advanced airway diseases, but whether it varies health unknown. We postulated that the primary determinant of constitution balance immigration and elimination communities from upper respiratory tract (URT; "adapted island model biogeography"), rather than differences regional bacterial growth conditions.To determine if varied healthy adults.Bronchoscopy was performed on 15 subjects. Specimens were sequentially collected lingula right middle...
Limited data exist describing risk factors for mortality in patients having predominantly emphysema.A total of 609 with severe emphysema (ages 40-83 yr; 64.2% male) randomized to the medical therapy arm National Emphysema Treatment Trial formed study group. Cox proportional hazards regression analysis was used investigate all-cause mortality. Risk examined included demographics, body mass index, physiologic data, quality life, dyspnea, oxygen utilization, hemoglobin, smoking history,...
Exacerbations of chronic obstructive pulmonary disease (COPD) are associated with accelerated loss lung function and death. Identification patients at risk for these events, particularly those requiring hospitalization, is major importance. Severe hypertension an important complication advanced COPD predicts acute exacerbations, though vascular abnormalities also occur early in the course disease. We hypothesized that a computed tomographic (CT) metric (pulmonary artery enlargement, as...
To test the hypothesis-given increasing emphasis on quantitative computed tomographic (CT) phenotypes of chronic obstructive pulmonary disease (COPD)-that a relationship exists between COPD exacerbation frequency and CT measures emphysema airway disease.This research protocol was approved by institutional review board each participating institution, all participants provided written informed consent. One thousand two subjects who were enrolled in COPDGene Study met GOLD (Global Initiative...
ABSTRACT Although culture-independent techniques have refuted lung sterility in health, controversy about contamination during bronchoscope passage through the upper respiratory tract (URT) has impeded research progress. We sought to establish whether bronchoscopic sampling accurately reflects microbiome health and distinguish between two proposed routes of authentic microbial immigration, (i) dispersion along contiguous mucosa (ii) subclinical microaspiration. During bronchoscopy eight...
<h3>Importance</h3> Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow may assume that they are free. <h3>Objective</h3> To identify clinical radiologic evidence of smoking-related in a cohort who did not meet spirometric criteria for COPD, whom we adopted the discarded label Global Initiative Obstructive Lung Disease (GOLD) 0. <h3>Design, Setting, Participants</h3> Individuals from...
ABSTRACT DNA from phylogenetically diverse microbes is routinely recovered healthy human lungs and used to define the lung microbiome. The proportion of this originating adapted lungs, as opposed dispersing other body sites atmosphere, not known. We use a neutral model community ecology distinguish members microbiome whose presence consistent with dispersal those that deviate model, suggesting competitive advantage these in lungs. find composition predictions reflecting overriding role oral...
Limited data on sex differences in advanced COPD are available.To compare male and female emphysema patients with severe disease.One thousand fifty-three (38.8% female) evaluated for lung volume reduction surgery as part of the National Emphysema Treatment Trial were analyzed.Detailed clinical, physiological, radiological assessment, including quantitation severity distribution from helical chest computed tomography, was completed. In a subgroup (n = 101), airway size thickness determined by...
Retrospective studies have shown that statins decrease the rate and severity of exacerbations, hospitalization, mortality in chronic obstructive pulmonary disease (COPD). We prospectively studied efficacy simvastatin preventing exacerbations a large, multicenter, randomized trial.
Rationale: Acute exacerbations of chronic obstructive pulmonary disease (COPD) increase the risk death and drive healthcare costs, but whether they accelerate loss lung function remains controversial. Whether in subjects with mild COPD or similar acute respiratory events smokers without airflow obstruction affect decline is unknown.Objectives: To determine association between (and COPD) change over 5 years follow-up.Methods: We examined data on first 2,000 who returned for a second COPDGene...
Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of preserved FEV1/FVC ratio, is highly prevalent and associated with increased respiratory symptoms, systemic inflammation, mortality. Studies investigating quantitative chest tomographic features, genetic associations, subtypes PRISm subjects have not been reported. Data from current former smokers enrolled COPDGene (n = 10,192), an observational, cross-sectional study which recruited aged 45–80 ≥10 pack...
Chronic obstructive pulmonary disease is a heterogeneous disorder with varying presentation and progression, but limited disease-modifying therapies.It increasingly evident that lung function trajectories in COPD differ significantly differences are detectable young adulthood.It important to distinguish "early disease" meaning the first signs of developing individual from "late mild may be severity an older have been present for decades.We propose operational definition early as occurring...
Increasing awareness of the prevalence and significance Preserved Ratio Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for Chronic Obstructive Lung Disease (GOLD)-unclassified spirometry, has expanded body knowledge on cross-sectional risk factors. However, longitudinal studies PRISm remain limited.