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Amit Parulekar

ORCID: 0000-0003-4828-4041
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A5063365600
Research Areas
  • Transplantation: Methods and Outcomes
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Asthma and respiratory diseases
  • Respiratory Support and Mechanisms
  • Organ Transplantation Techniques and Outcomes
  • Respiratory and Cough-Related Research
  • Renal Transplantation Outcomes and Treatments
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Pulmonary Hypertension Research and Treatments
  • IL-33, ST2, and ILC Pathways
  • Polyomavirus and related diseases
  • Mechanical Circulatory Support Devices
  • Tracheal and airway disorders
  • Medical Imaging and Pathology Studies
  • Allergic Rhinitis and Sensitization
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Pleural and Pulmonary Diseases
  • Cardiac Arrhythmias and Treatments
  • Healthcare professionals’ stress and burnout
  • Delphi Technique in Research
  • Respiratory viral infections research
  • Trauma Management and Diagnosis
  • Immune Cell Function and Interaction
  • Eosinophilic Esophagitis
  • Atrial Fibrillation Management and Outcomes

AstraZeneca (Switzerland)
 2025

Baylor College of Medicine
 2012-2023

Roche (Switzerland)
 2022

Vanderbilt University Medical Center
 2020-2021

Vanderbilt University
 2020

Indiana University – Purdue University Indianapolis
 2020

St. Luke's Medical Center
 2019

St. Luke's Hospital
 2017

Washington University in St. Louis
 2010-2013

Methodist Hospital
 2012

 Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study
OPENALEX - Publications 
Emily S. Wan Spyridon Fortis Elizabeth A. Regan John E. Hokanson MeiLan K. Han and 95 more Richard Casaburi Barry J. Make James D. Crapo Dawn L. DeMeo Edwin K. Silverman James D. Crapo Edwin K. Silverman Barry J. Make Elizabeth A. Regan Terri H. Beaty Ferdouse Begum Peter J. Castaldi Michael H. Cho Dawn L. DeMeo Adel R. Boueiz Marilyn G. Foreman Eitan Halper-Stromberg Lystra P. Hayden Craig P. Hersh Jacqueline B. Hetmanski Brian D. Hobbs John E. Hokanson Nan M. Laird Christoph Lange Sharon M. Lutz Merry‐Lynn McDonald Margaret M. Parker Dandi Qiao Elizabeth A. Regan Edwin K. Silverman Emily S. Wan Sungho Won Phuwanat Sakornsakolpat Dmitry Prokopenko Mustafa Al Qaisi Harvey O. Coxson Teresa Gray MeiLan K. Han Eric A. Hoffman Stephen M. Humphries Francine L. Jacobson Philip F. Judy Ella A. Kazerooni Alex Kluiber David A. Lynch John D. Newell Elizabeth A. Regan James C. Ross Raúl San Jośe Estépar Joyce Schroeder Jered Sieren Douglas Stinson Berend C. Stoel Juerg Tschirren Edwin J.R. van Beek Bram van Ginneken Eva M. van Rikxoort George R. Washko Carla G. Wilson Robert L. Jensen Douglas Curran‐Everett Jim Crooks Camille M. Moore Matthew Strand Carla G. Wilson John E. Hokanson J A Hughes Gregory L. Kinney Sharon M. Lutz Katherine Pratte Kendra A. Young Surya P. Bhatt Jessica Bon MeiLan K. Han Barry J. Make Carlos Martínez Susan Murray Elizabeth A. Regan Xavier Soler Carla G. Wilson Russell P. Bowler Katerina Kechris Farnoush Banaei‐Kashani Jeffrey L. Curtis Cristina Martínez Perry G. Pernicano Nicola A. Hanania Philip Alapat Mustafa Atik Venkata Bandi Aladin M. Boriek Kalpatha Guntupalli Elizabeth Guy Arun C. Nachiappan Amit Parulekar

Increasing awareness of the prevalence and significance Preserved Ratio Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for Chronic Obstructive Lung Disease (GOLD)-unclassified spirometry, has expanded body knowledge on cross-sectional risk factors. However, longitudinal studies PRISm remain limited.

10.1164/rccm.201804-0663oc article EN American Journal of Respiratory and Critical Care Medicine 2018-06-06
 Blood eosinophil count thresholds and exacerbations in patients with chronic obstructive pulmonary disease
OPENALEX - Publications 
Jeong H. Yun Andrew Lamb Robert Chase Dave Singh Margaret M. Parker and 95 more Aabida Saferali Jørgen Vestbo Ruth Tal‐Singer Peter J. Castaldi Edwin K. Silverman Craig P. Hersh James D. Crapo Edwin K. Silverman Barry J. Make Elizabeth A. Regan Terri H. Beaty Ferdouse Begum Robert Busch Peter J. Castaldi Michael Cho Dawn L. DeMeo Adel R. Boueiz Marilyn G. Foreman Eitan Halper-Stromberg Nadia N. Hansel Megan Hardin Lystra P. Hayden Craig P. Hersh Jacqueline B. Hetmanski Brian D. Hobbs John E. Hokanson Nan M. Laird Christoph Lange Sharon M. Lutz Merry‐Lynn McDonald Margaret M. Parker Dandi Qiao Elizabeth A. Regan Stephanie Santorico Edwin K. Silverman Emily S. Wan Sungho Won Mustafa Al Qaisi Harvey O. Coxson Teresa Gray MeiLan K. Han Eric A. Hoffman Steve E. Humphries Francine L. Jacobson Philip F. Judy Ella A. Kazerooni Alex Kluiber David A. Lynch John D. Newell Elizabeth A. Regan James C. Ross Raúl San Jośe Estépar Joyce Schroeder Jered Sieren Douglas R. Stinson Berend C. Stoel Juerg Tschirren Edwin J.R. van Beek Bram van Ginneken Eva M. van Rikxoort George R. Washko Carla G. Wilson Robert T. Jensen D. H. Everett Jim Crooks Camille M. Moore Matthew Strand Carla G. Wilson John E. Hokanson John P. Hughes Gregory L. Kinney Sharon M. Lutz Katherine Pratte Kendra A. Young Jeffrey L. Curtis Cristina Martínez Perry G. Pernicano Nicola A. Hanania Philip Alapat Mustafa Atik Venkata Bandi Aladin M. Boriek Kalpatha Guntupalli Elizabeth Guy Arun C. Nachiappan Amit Parulekar Dawn L. DeMeo Craig P. Hersh Francine L. Jacobson George R. Washko R. Graham Barr John Austin Belinda D’Souza Gregory D. Pearson Anna Rozenshtein

10.1016/j.jaci.2018.04.010 article EN publisher-specific-oa Journal of Allergy and Clinical Immunology 2018-04-28
 Disease Progression Modeling in Chronic Obstructive Pulmonary Disease
OPENALEX - Publications 
Alexandra L. Young Felix Bragman Bojidar Rangelov MeiLan K. Han Craig J. Galbán and 95 more David A. Lynch David J. Hawkes Daniel C. Alexander John R. Hurst James D. Crapo Edwin K. Silverman Barry J. Make Elizabeth A. Regan Terri H. Beaty Ferdouse Begum Peter J. Castaldi Michael Cho Dawn L. DeMeo Adel R. Boueiz Marilyn G. Foreman Eitan Halper-Stromberg Lystra P. Hayden Craig P. Hersh Jacqueline B. Hetmanski Brian D. Hobbs John E. Hokanson Nan M. Laird Christoph Lange Sharon M. Lutz Merry‐Lynn McDonald Margaret M. Parker Dandi Qiao Emily S. Wan Sungho Won Phuwanat Sakornsakolpat Dmitry Prokopenko Mustafa Al Qaisi Harvey O. Coxson Teresa Gray MeiLan K. Han Eric A. Hoffman Stephen M. Humphries Francine L. Jacobson Philip F. Judy Ella A. Kazerooni Alex Kluiber David A. Lynch John D. Newell James C. Ross Raúl San Jośe Estépar Joyce Schroeder Jered Sieren Douglas Stinson Berend C. Stoel Juerg Tschirren Edwin J.R. van Beek Bram van Ginneken Eva M. van Rikxoort George R. Washko Carla G. Wilson Robert L. Jensen Douglas Curran‐Everett Jim Crooks Camille M. Moore Matthew Strand J A Hughes Gregory L. Kinney Katherine Pratte Kendra A. Young Surya P. Bhatt Jessica Bon Cristina Martínez Susan Murray Xavier Soler Russell P. Bowler Katerina Kechris Farnoush Banaei‐Kashani Jeffrey L. Curtis Cristina Martínez Perry G. Pernicano Nicola A. Hanania Philip Alapat Mustafa Atik Venkata Bandi Aladin M. Boriek Kalpatha Guntupalli Elizabeth Guy Arun C. Nachiappan Amit Parulekar R. Graham Barr John Austin Belinda D’Souza Gregory D. Pearson Anna Rozenshtein Byron Thomashow Neil MacIntyre H. Page McAdams Lacey Washington Charlene McEvoy Joseph Tashjian

Rationale: The decades-long progression of chronic obstructive pulmonary disease (COPD) renders identifying different trajectories challenging.Objectives: To identify subtypes patients with COPD distinct longitudinal patterns using a novel machine-learning tool called "Subtype and Stage Inference" (SuStaIn) to evaluate the utility SuStaIn for patient stratification in COPD.Methods: We applied cross-sectional computed tomography imaging markers 3,698 Global Initiative Chronic Obstructive Lung...

10.1164/rccm.201908-1600oc article EN American Journal of Respiratory and Critical Care Medicine 2019-10-28
 Chronic Obstructive Pulmonary Disease Exacerbations Increase the Risk of Subsequent Cardiovascular Events: A Longitudinal Analysis of the COPDGene Study
OPENALEX - Publications 
Han‐Mo Yang Min Hyung Ryu Vincent J. Carey Gregory L. Kinney John E. Hokanson and 95 more Mark T. Dransfield Craig P. Hersh Edwin K. Silverman James D. Crapo Edwin K. Silverman Barry J. Make Elizabeth A. Regan Terri H. Beaty Peter J. Castaldi Michael H. Cho Dawn L. DeMeo Adel Boueiz Marilyn G. Foreman Auyon Ghosh Lystra P. Hayden Craig P. Hersh Jacqueline B. Hetmanski Brian D. Hobbs John E. Hokanson Wonji Kim Nan M. Laird Christoph Lange Sharon M. Lutz Merry‐Lynn McDonald Dmitry Prokopenko Matthew Moll Jarrett D. Morrow Dandi Qiao Elizabeth A. Regan Aabida Saferali Phuwanat Sakornsakolpat Edwin K. Silverman Emily S. Wan Jeong H. Yun Juan Pablo Centeno Jean‐Paul Charbonnier Harvey O. Coxson Craig J. Galbán MeiLan K. Han Eric A. Hoffman Stephen M. Humphries Francine L. Jacobson Philip F. Judy Ella A. Kazerooni Alex Kluiber David A. Lynch Pietro Nardelli John D. Newell Aleena Notary Andrea Oh Elizabeth A. Regan James C. Ross Raúl San Jośe Estépar Joyce Schroeder Jered Sieren Berend C. Stoel Juerg Tschirren Edwin J.R. van Beek Bram van Ginneken Eva M. van Rikxoort Gonzalo Vegas‐Sánchez‐Ferrero Lucas Veitel George R. Washko Carla G. Wilson Robert L. Jensen Douglas Curran‐Everett Jim Crooks Katherine Pratte Matthew Strand Carla G. Wilson John E. Hokanson Erin Austin Gregory L. Kinney Sharon M. Lutz Kendra A. Young Surya P. Bhatt Jessica Bon Alejandro A. Díaz MeiLan K. Han Barry J. Make Susan Murray Elizabeth Regan Xavier Soler Carla G. Wilson Russell P. Bowler Katerina Kechris Farnoush Banaei‐Kashani Jeffrey L. Curtis Perry G. Pernicano Nicola A. Hanania Mustafa Atik Aladin M. Boriek Kalpatha Guntupalli Elizabeth Guy Amit Parulekar

Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary (COPD). COPD exacerbations not only contribute to progression but may also elevate risk of CVD. This study aimed determine whether increase subsequent CVD events using up 15 years prospective longitudinal follow-up data from COPDGene (Genetic Epidemiology Chronic Obstructive Pulmonary Disease) study.

10.1161/jaha.123.033882 article EN cc-by-nc-nd Journal of the American Heart Association 2024-05-31
 Initial skin cancer screening for solid organ transplant recipients in the United States: Delphi method development of expert consensus guidelines
OPENALEX - Publications 
Lauren Crow Anokhi Jambusaria‐Pahlajani Christina Lee Chung David A. Baran Stefan E. Lowenstein and 81 more Mark Abdelmalek Rehana L. Ahmed Milan J. Anadkat Selim M. Arcasoy Daniel Berg Kristin Bibee Elizabeth M. Billingsley William H. Black Travis W. Blalock Melissa Bleicher Daniel C. Brennan David G. Brodland Mariah Brown Bryan T. Carroll John A. Carucci Timothy W. Chang George Chaux Carrie Ann Cusack Daniel F. Dilling Alden Doyle A. Emtiazjoo Nkanyezi H. Ferguson Scott W. Fosko Matthew C. Fox Simin Göral Alice Gray John R. Griffin Ramsey R. Hachem Shelley Hall Allison Hanlon Don Hayes Gavin W. Hickey Jonathan E. Holtz R. Samuel Hopkins Jenny Hu Conway C. Huang Shang I. Brian Jiang Siddhartha G. Kapnadak Edward S. Kraus Erika D. Lease Nicolae Leca James Lee Justin J. Leitenberger Mary Ann Lim María Isabel Longo Shahid M. Malik Jorge M. Mallea Alan Menter Sarah A. Myers Marcy Neuburg Rajiv I. Nijhawan Douglas J. Norman Clark C. Otley So Yeon Paek Amit Parulekar Manisha J. Patel Vishal A. Patel Timothy Patton Melissa Pugliano‐Mauro Karthik Ranganna Ashwin Ravichandran Rachel Redenius Garrett R. Roll Faramarz H. Samie Thuzar M. Shin Jonathan P. Singer Pooja Singh Seaver L. Soon Teresa Soriano Ronald A. Squires Thomas Stasko Jennifer Stein Sandra J. Taler Norah A. Terrault Christie P. Thomas Sofya Tokman Rade Tomic Amanda R. Twigg M. Wigger Nathalie C. Zeitouni Sarah T. Arron

10.1111/tri.13520 article EN Transplant International 2019-09-10
 Combined Forced Expiratory Volume in 1 Second and Forced Vital Capacity Bronchodilator Response, Exacerbations, and Mortality in Chronic Obstructive Pulmonary Disease
OPENALEX - Publications 
Spyridon Fortis Alejandro P. Comellas Barry J. Make Craig P. Hersh Sandeep Bodduluri and 95 more Dimitris Georgopoulos Victor Kim Gerard J. Criner Mark T. Dransfield Surya P. Bhatt James D. Crapo Edwin K. Silverman Barry J. Make Elizabeth A. Regan Terri H. Beaty Ferdouse Begum Robert Busch Peter J. Castaldi Michael Cho Dawn L. DeMeo Adel R. Boueiz Marilyn G. Foreman Eitan Halper-Stromberg Nadia N. Hansel Megan Hardin Lystra P. Hayden Craig P. Hersh Jacqueline B. Hetmanski Brian D. Hobbs John E. Hokanson Nan M. Laird Christoph Lange Sharon M. Lutz Merry‐Lynn McDonald Margaret M. Parker Dandi Qiao Elizabeth A. Regan Stephanie Santorico Edwin K. Silverman Emily S. Wan Sungho Won Mustafa Al Qaisi Harvey O. Coxson Teresa Gray MeiLan K. Han Eric A. Hoffman Stephen M. Humphries Francine L. Jacobson Philip F. Judy Ella A. Kazerooni Alex Kluiber David A. Lynch John D. Newell Elizabeth A. Regan James C. Ross Raúl San Jośe Estépar Joyce Schroeder Jered Sieren Douglas Stinson Berend C. Stoel Juerg Tschirren Edwin J.R. van Beek Bram van Ginneken Eva M. van Rikxoort George R. Washko Carla G. Wilson Robert T. Jensen D. H. Everett Jim Crooks Camille M. Moore Matthew Strand Carla G. Wilson John E. Hokanson John P. Hughes Gregory L. Kinney Sharon M. Lutz Katherine Pratte Kendra A. Young Jeffrey L. Curtis Cristina Martínez Perry G. Pernicano Nicola A. Hanania Philip Alapat Mustafa Atik Venkata Bandi Aladin M. Boriek Kalpatha Guntupalli Elizabeth Guy Arun C. Nachiappan Amit Parulekar Dawn L. DeMeo Craig P. Hersh Francine L. Jacobson George R. Washko R. Graham Barr John Austin Belinda D’Souza Gregory D. Pearson Anna Rozenshtein Byron Thomashow

Rationale: The American Thoracic Society (ATS)/European Respiratory defines a positive bronchodilator response (BDR) by composite of BDR in either forced expiratory volume 1 second (FEV1) and/or vital capacity (FVC) greater than or equal to 12% and 200 ml (ATS-BDR). We hypothesized that ATS-BDR components would be differentially associated with important chronic obstructive pulmonary disease (COPD) outcomes. Objectives: To examine whether are clinical, functional, radiographic features COPD....

10.1513/annalsats.201809-601oc article EN Annals of the American Thoracic Society 2019-03-25
 Fungal Sensitization Is Associated with Increased Risk of Life-Threatening Asthma
OPENALEX - Publications 
Sarah Medrek Christina C. Kao Danny H Yang Nicola A. Hanania Amit Parulekar

10.1016/j.jaip.2016.11.015 article EN The Journal of Allergy and Clinical Immunology In Practice 2016-12-22
 The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition
OPENALEX - Publications 
V. Kim Huaqing Zhao Elizabeth A. Regan MeiLan K. Han Barry J. Make and 95 more James D. Crapo Paul Jones Jeffrey L. Curtis Edwin K. Silverman Gerard J. Criner James D. Crapo Edwin K. Silverman Barry J. Make Elizabeth A. Regan Terri H. Beaty Ferdouse Begum Robert Busch Peter J. Castaldi Michael Cho Dawn L. DeMeo Adel R. Boueiz Marilyn G. Foreman Eitan Halper-Stromberg Nadia N. Hansel Megan Hardin Lystra P. Hayden Craig P. Hersh Jacqueline B. Hetmanski Brian D. Hobbs John E. Hokanson Nan M. Laird Christoph Lange Sharon M. Lutz Merry‐Lynn McDonald Margaret M. Parker Dandi Qiao Elizabeth A. Regan Stephanie Santorico Edwin K. Silverman Emily S. Wan Sungho Won Jean‐Paul Charbonnier Harvey O. Coxson MeiLan K. Han Eric A. Hoffman Stephen M. Humphries Francine L. Jacobson Philip F. Judy Ella A. Kazerooni Alex Kluiber David A. Lynch John D. Newell Elizabeth A. Regan James C. Ross Raúl San Jośe Estépar Jered Sieren Berend C. Stoel Juerg Tschirren Edwin J.R. van Beek Bram van Ginneken Eva M. van Rikxoort George R. Washko Carla G. Wilson Robert T. Jensen Douglas Curran‐Everett Jim Crooks Camille M. Moore Matthew Strand Carla G. Wilson John E. Hokanson John P. Hughes Gregory L. Kinney Sharon M. Lutz Katherine Pratte Kendra A. Young Jeffrey L. Curtis Cristina Martínez Perry G. Pernicano Nicola A. Hanania Philip Alapat Mustafa Atik Venkata Bandi Aladin M. Boriek Kalpatha Guntupalli Elizabeth Guy Arun C. Nachiappan Amit Parulekar Dawn L. DeMeo Craig P. Hersh Francine L. Jacobson George R. Washko R. Graham Barr John Austin Belinda D’Souza Gregory D. Pearson Anna Rozenshtein Byron Thomashow Neil MacIntyre H. Page McAdams Lacey Washington

10.1016/j.chest.2019.03.041 article EN CHEST Journal 2019-05-15
 Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression
OPENALEX - Publications 
Adel Boueiz Yale Chang Michael H. Cho George R. Washko Raúl San Jośe Estépar and 95 more Russell P. Bowler James D. Crapo Dawn L. DeMeo Jennifer Dy Edwin K. Silverman Peter J. Castaldi James D. Crapo Edwin K. Silverman Barry J. Make Elizabeth A. Regan Terri H. Beaty Nan M. Laird Christoph Lange Michael H. Cho Stephanie A. Santorico John E. Hokanson Dawn L. DeMeo Nadia N. Hansel Craig P. Hersh Peter J. Castaldi Merry‐Lynn McDonald Emily S. Wan Megan Hardin Jacqueline B. Hetmanski Margaret M. Parker Marilyn G. Foreman Brian D. Hobbs Robert Busch Adel Boueiz Peter J. Castaldi Megan Hardin Dandi Qiao Elizabeth A. Regan Eitan Halper-Stromberg Ferdouse Begum Sungho Won Sharon M. Lutz David A. Lynch Harvey O. Coxson MeiLan K. Han Eric A. Hoffman Stephen M. Humphries Francine L. Jacobson Philip F. Judy Ella A. Kazerooni John D. Newell Elizabeth A. Regan James C. Ross Raul José Estépar Berend C. Stoel Juerg Tschirren Eva M. van Rikxoort Bram van Ginneken George R. Washko Carla G. Wilson Mustafa Al Qaisi Teresa Gray Alex Kluiber Tanya Mann Jered Sieren Douglas Stinson Joyce Schroeder Edwin J.R. van Beek Robert L. Jensen Douglas Curran‐Everett Anna Faino Matthew Strand Carla G. Wilson John E. Hokanson Gregory L. Kinney Sharon M. Lutz Kendra A. Young Katherine Pratte Lindsey M. Duca Jeffrey L. Curtis Cristina Martínez Perry G. Pernicano Nicola A. Hanania Philip Alapat Venkata Bandi Mustafa Atik Aladin M. Boriek Kalpatha Guntupalli Elizabeth Guy Amit Parulekar Arun C. Nachiappan Dawn L. DeMeo Craig P. Hersh George R. Washko Francine L. Jacobson R. Graham Barr Byron Thomashow John Austin Belinda D’Souza Gregory D. Pearson

10.1016/j.chest.2017.09.022 article EN CHEST Journal 2017-09-22
 Age-Related Differences in Health-Related Quality of Life in COPD
OPENALEX - Publications 
Cristina Martínez Alejandro A. Díaz Amit Parulekar Stephen I. Rennard Richard E. Kanner and 11 more Nadia N. Hansel David Couper Kristen E. Holm Karin F. Hoth Jeffrey L. Curtis Fernando J. Martínez Nicola A. Hanania Elizabeth A. Regan Robert Paine Christine T. Cigolle MeiLan K. Han

10.1016/j.chest.2015.11.025 article EN CHEST Journal 2015-12-17
 A Randomized Controlled Trial to Evaluate Inhibition of T-Cell Costimulation in Allergen-induced Airway Inflammation
OPENALEX - Publications 
Amit Parulekar Jonathan Boomer Brenda Patterson Huiqing Yin‐Declue Christine Deppong and 4 more Brad S. Wilson Nizar N. Jarjour Mario Castro Jonathan M. Green

T lymphocytes are important in the pathogenesis of allergic asthma. Costimulation through CD28 is critical for optimal activation cells, and inhibition this pathway with CTLA4Ig has been shown to be effective preventing airway inflammation hyperresponsiveness animal models Abatacept, a humanized version CTLA4Ig, approved treatment rheumatoid arthritis, providing opportunity test whether costimulation an strategy treat people asthma.To determine if 3 months abatacept reduced allergen-induced...

10.1164/rccm.201207-1205oc article EN American Journal of Respiratory and Critical Care Medicine 2013-01-06
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