Aladin M. Boriek
A5058695747- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Muscle Physiology and Disorders
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Muscle activation and electromyography studies
- Cellular Mechanics and Interactions
- Cardiomyopathy and Myosin Studies
- Exercise and Physiological Responses
- RNA Research and Splicing
- Respiratory and Cough-Related Research
- Pleural and Pulmonary Diseases
- Sirtuins and Resveratrol in Medicine
- Shoulder Injury and Treatment
- Pulmonary Hypertension Research and Treatments
- Inhalation and Respiratory Drug Delivery
- Nutrition and Health in Aging
- Elasticity and Material Modeling
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sports injuries and prevention
- Skin and Cellular Biology Research
- Cell Adhesion Molecules Research
- Cardiovascular and Diving-Related Complications
Baylor College of Medicine
2015-2025
Michael E. DeBakey VA Medical Center
2004
University of Salerno
1997
University of Minnesota
1997
University of Pennsylvania
1996
Rice University
1988-1992
Rationale: The small conducting airways are the major site of airflow obstruction in chronic obstructive pulmonary disease and may precede emphysema development.Objectives: We hypothesized a novel computed tomography (CT) biomarker airway predicts FEV1 decline.Methods: analyzed 1,508 current former smokers from COPDGene with linear regression to assess predictors change (ml/yr) over 5 years. Separate models for subjects without were generated using baseline clinical physiologic addition two...
Increasing awareness of the prevalence and significance Preserved Ratio Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for Chronic Obstructive Lung Disease (GOLD)-unclassified spirometry, has expanded body knowledge on cross-sectional risk factors. However, longitudinal studies PRISm remain limited.
Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified substantial number individuals without COPD who suffer from respiratory symptoms and/or increased There is clear need for an expanded definition that linked to physiologic, structural (computed tomography [CT]) clinical disease. Using data the Genetic Epidemiology study (COPDGene
The ex vivo effects of passive mechanical stretch on the activation nuclear factor-kappaB (NF-kappaB) pathways in skeletal muscles from normal and mdx mouse, a model Duchenne muscular dystrophy (DMD), were investigated. NF-kappaB/DNA binding activity diaphragm muscle was increased by application axial time-dependent manner. NF-kappaB associated with concomitant increase I-kappaB (IkappaB) kinase degradation IkappaBalpha protein. Pretreatment nifedipine (a Ca2+ channel blocker)...
Airway smooth muscle hypertrophy is one of the hallmarks airway remodeling in severe asthma. Several human diseases have been now associated with dysregulated microRNA (miRNA) expression. miRNAs are a class small non-coding RNAs, which negatively regulate gene expression at post-transcriptional level. Here, we identify miR-26a as hypertrophic miRNA cells (HASMCs). We show that stretch selectively induces transcription located locus 3p21.3 chromosome 3. The factor CCAAT enhancer-binding...
High-fat diet (HFD) plays a central role in the initiation of mitochondrial dysfunction that significantly contributes to skeletal muscle metabolic disorders obesity. However, mechanism by which HFD weakens metabolism altering function and biogenesis is unknown. Given emerging roles microRNAs (miRNAs) regulation metabolism, we sought determine whether activation specific miRNA pathway would rescue HFD-induced via sirtuin-1 (SIRT-1)/ peroxisome proliferator–activated receptor γ coactivator-1α...
Rationale: The decades-long progression of chronic obstructive pulmonary disease (COPD) renders identifying different trajectories challenging.Objectives: To identify subtypes patients with COPD distinct longitudinal patterns using a novel machine-learning tool called "Subtype and Stage Inference" (SuStaIn) to evaluate the utility SuStaIn for patient stratification in COPD.Methods: We applied cross-sectional computed tomography imaging markers 3,698 Global Initiative Chronic Obstructive Lung...
Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary (COPD). COPD exacerbations not only contribute to progression but may also elevate risk of CVD. This study aimed determine whether increase subsequent CVD events using up 15 years prospective longitudinal follow-up data from COPDGene (Genetic Epidemiology Chronic Obstructive Pulmonary Disease) study.
Dystrophin is a cytoskeletal protein found at the inner surface of skeletal and cardiac muscle fibers. We hypothesize that deficiency dystrophin increases compliance causes an aberrant mechanotransduction in To test this hypothesis, we measured length-tension relationships determined intracellular signaling leading to activation mitogen-activated (MAP) kinases diaphragm fibers from dystrophin-deficient mdx mice. Compared with controls, curves mice were shifted right. A higher level...
Skeletal muscle aging is associated with increased inflammation and oxidative stress, a decrease in the ability to rebuild after injury response exercise. In this perspective, we discuss mechanisms regulating Sirt1 activity expression skeletal muscles, emphasizing their implications physiology impairment of function age.
In the diaphragm muscle we tested hypothesis that MAP kinase signaling pathways are activated by mechanical stress and such dependent on direction in which is applied. Although equal magnitudes of were applied axially transversely a greater level activation ERK1/2, p38, Raf-1, p90 RSK, Elk-1, DNA binding activity AP-1 transcription factor was produced when stretched than axially. A significant up-regulation protein tyrosine phosphorylation observed or loaded muscles ERK1/2 completely...
We investigated the effects of mechanical stretch and induced stimulation lung parenchyma on activation proinflammatory transcription factors in normal mice a mouse model asthma. Mechanical stretching led to increased NF-kappaB AP-1 factors. Incubation with methacholine NF-kappaB, which was further augmented by stretch. Activation response associated phosphorylation degradation IkappaBalpha IkappaB kinase. Stretch-induced involves stretch-activated (SA) channels production free radicals....
Mechanical loading of muscles by intrinsic muscle activity or passive stretch leads to an increase in the production reactive oxygen species. The NAD-dependent protein deacetylase SIRT1 is involved protection against oxidative stress enhancing FOXO-driven Sod2 transcription. In this report, we unravel a mechanism triggered mechanical skeletal cells that EGR1-dependent transcriptional activation Sirt1 gene. resulting transient expression generates antioxidative response contributes species scavenging.
Low muscle mass is associated with increased mortality in the general population but its prognostic value at-risk smokers, those without expiratory airflow obstruction, unknown. We aimed to test hypothesis that reduced smokers. Measures of both pectoralis and paravertebral erector spinae cross-sectional area (PMA PVMA, respectively) as well emphysema on chest computed tomography (CT) scans were performed 3705 current former smokers (≥10 pack-years) aged 45–80 years enrolled into COPDGene...
Rationale: The American Thoracic Society (ATS)/European Respiratory defines a positive bronchodilator response (BDR) by composite of BDR in either forced expiratory volume 1 second (FEV1) and/or vital capacity (FVC) greater than or equal to 12% and 200 ml (ATS-BDR). We hypothesized that ATS-BDR components would be differentially associated with important chronic obstructive pulmonary disease (COPD) outcomes. Objectives: To examine whether are clinical, functional, radiographic features COPD....
Striated muscle is a linear motor whose properties have been defined in terms of uniaxial structures. The question addressed here what contribution made to the this by extramyofilament cytoskeletal structures that are not aligned parallel with myofilaments. This arose from observations transverse loads increase force production diaphragm but hindlimb muscle, thereby indicating presence couple longitudinal and diaphragmatic muscle. Furthermore, we find diaphragms null mutants for protein...
Here we investigated the mechanisms by which mechanical stretch regulates production of IL-8 in primary human airway smooth muscle cells (HASMC). Bronchial HASMC were subjected to cyclic (12%, 1 Hz) using computer-controlled Flexcell Strain system. Mechanical increased mRNA expression and protein production. Cyclic also kinase activities ERK1/2, JNK1, p38, DNA binding AP-1 C/EBP transcription factors with little effect on NF-κB. The inhibition transcriptional blocked culture supernatants....
The effect of incision length, location, and shape on the structural integrity globe was examined using finite element analysis by comparing radial deformation corneoscleral tissue adjacent to incision. results show that length had greatest adverse effect, 12 mm incisions causing deformations an order magnitude higher than distension intact at 20 Hg. least disturbance produced 3 scleral pocket incisions.