Adel Boueiz
A5055915095- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Genetic Associations and Epidemiology
- Pulmonary Hypertension Research and Treatments
- Asthma and respiratory diseases
- RNA modifications and cancer
- Genomics and Rare Diseases
- Delphi Technique in Research
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA Research and Splicing
- Neonatal Respiratory Health Research
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Liver Disease and Transplantation
- Lung Cancer Diagnosis and Treatment
- Machine Learning in Bioinformatics
- Acute Myeloid Leukemia Research
- Cancer Genomics and Diagnostics
Harvard University
2017-2025
Harvard University Press
2021-2025
Brigham and Women's Hospital
2017-2024
Pulmonary and Critical Care Associates
2010-2023
Beth Israel Deaconess Medical Center
2021
RELX Group (United States)
2020
Johns Hopkins University
2008-2014
Johns Hopkins Medicine
2008-2011
American University of Beirut
2008
American University of Beirut Medical Center
2007
Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)–dependent vascular dysfunction, HIF-2α promoted expression neighboring genes, long noncoding RNA (lncRNA) histone lysine N -methyltransferase 2E-antisense 1 ( KMT2E-AS1 ) N-methyltransferase 2E KMT2E ). stabilized protein to increase epigenetic 3 4 trimethylation (H3K4me3),...
Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary (COPD). COPD exacerbations not only contribute to progression but may also elevate risk of CVD. This study aimed determine whether increase subsequent CVD events using up 15 years prospective longitudinal follow-up data from COPDGene (Genetic Epidemiology Chronic Obstructive Pulmonary Disease) study.
Objective In the hospital setting, several studies have reported proton pump inhibitor (PPI) overuse, a majority of which is continued after discharge. addition to being expensive, PPIs are associated with an increased risk infections, osteoporosis and serious drug interactions. We examined trends predictors PPI guidelines non-compliance among academic non- hospitalists in USA. Methods Patients Oral prescriptions initiated by 2 non-academic hospitalist groups were reviewed. Prescription...
Cigarette smoking contributes to the risk of death through different mechanisms.
Rationale: Emphysema has considerable variability in the severity and distribution of parenchymal destruction throughout lungs. Upper lobe–predominant emphysema emerged as an important predictor response to lung volume reduction surgery. Yet, aside from alpha-1 antitrypsin deficiency, genetic determinants remain largely unknown.Objectives: To identify influences non–alpha-1 antitrypsin–deficient smokers.Methods: A total 11,532 subjects with complete genotype computed tomography densitometry...
Signaling via p38 MAP kinase has been implicated in the mechanotransduction associated with mechanical stress and ventilator-induced lung injury (VILI). However, critical downstream mediators of alveolar remain incompletely defined. We provide evidence that high-tidal volume ventilation (HVt MV) rapidly activates caspases within lung, resulting increased cell apoptosis. Antagonism MV-induced activity SB-203580 suppresses both caspase apoptosis, placing upstream activation programmed death....
Recent evidence indicates that a higher plasma level of 25-hydroxyvitamin D [25(OH)D] is associated with lower adiposity and reduced number metabolic disturbances (MetD).We examined associations among dietary quality, 25(OH)D, percent body fat (%BF), MetD, pathway linking them, across central obesity.This cross-sectional nationally representative study used extensive data from the National Health Nutrition Examination Surveys 2001-2004.U.S. adults aged at least 20 yr were stratified by...
Mechanical ventilation, a fundamental therapy for acute lung injury, worsens pulmonary vascular permeability by exacting mechanical stress on various components of the respiratory system causing ventilator associated injury. We postulated that MK2 activation via p38 MAP kinase induced HSP25 phosphorylation, in response to stress, leading actin fiber formation and endothelial barrier dysfunction. sought determine role its downstream effector phosphorylation Wild type MK2−/− mice received...
We examined the relationship of elevated depressive symptoms with antioxidant status. Cross-sectional data from National Health and Nutrition Examination Surveys 2005–6 on US adults aged 20–85 years were analysed. Depressive measured using Patient Questionnaire a score cut-off point 10 to define ‘elevated symptoms’. Serum status was by serum levels carotenoids, retinol (free retinyl esters), vitamin C E. The main analyses consisted multiple logistic zero-inflated Poisson regression models,...
Multiple studies have demonstrated an increased risk of chronic obstructive pulmonary disease (COPD) in heterozygous carriers the AAT (alpha-1 antitrypsin) Z allele. However, it is not known if MZ subjects with COPD are phenotypically different from noncarriers (MM genotype) COPD.
The ability of peripheral blood biomarkers to assess chronic obstructive pulmonary disease (COPD) risk and progression is unknown. Genetics gene expression may capture important aspects COPD-related biology that predict activity.
The coagulation system is central to the pathophysiology of acute lung injury. We have previously demonstrated that anticoagulant activated protein C (APC) prevents increased endothelial permeability in response edemagenic agonists cells and this protection dependent on receptor (EPCR). currently investigate effect APC a mouse model ventilator-induced injury (VILI). C57BL/6J mice received spontaneous ventilation (control) or mechanical (MV) with high (HV T ; 20 ml/kg) low (LV 7 tidal volumes...
Although herpes simplex virus (HSV)-1 and HSV-2 may co-exist interact, some epidemiologic features including geographical distribution, secular trends, route of transmission, established risk factors distinguish these HSV sub-types. With recent data indicating a link between genital either strain, re-evaluation for HSV-1/HSV-2 infection co-infection is needed.We used the 1999-2004 National Health Nutrition Examination Study (NHANES) logistic regression modeling to identify socio-demographic...
Emphysema is a chronic obstructive pulmonary disease phenotype with important prognostic implications. Identifying blood-based biomarkers of emphysema will facilitate early diagnosis and development targeted therapies.
Chronic obstructive pulmonary disease (COPD) exhibits considerable progression heterogeneity. We hypothesized that elastic principal graph analysis (EPGA) would identify distinct clinical phenotypes and their longitudinal relationships.