Yingze Zhang
A5100747020- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hemoglobinopathies and Related Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Iron Metabolism and Disorders
- Genetic Associations and Epidemiology
- Pulmonary Hypertension Research and Treatments
- Epigenetics and DNA Methylation
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Sarcoidosis and Beryllium Toxicity Research
- Pneumonia and Respiratory Infections
- Medical Imaging and Pathology Studies
- Folate and B Vitamins Research
- Telomeres, Telomerase, and Senescence
- Intensive Care Unit Cognitive Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Air Quality and Health Impacts
- Transplantation: Methods and Outcomes
- RNA modifications and cancer
- Nosocomial Infections in ICU
- Genomics and Rare Diseases
- Biomarkers in Disease Mechanisms
- COVID-19 Clinical Research Studies
- Sepsis Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
University of Pittsburgh
2016-2025
Hebei Medical University
2021-2025
Third Hospital of Hebei Medical University
2021-2025
State Key Laboratory of Polymer Physics and Chemistry
2024-2025
Changchun Institute of Applied Chemistry
2024-2025
University of Science and Technology of China
2024-2025
Chinese Academy of Sciences
2024-2025
Nankai University
2025
University of Pittsburgh Medical Center
2007-2024
Hospital of Hebei Province
2021-2024
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease associated with substantial morbidity and mortality. The objective of this study was to determine whether there peripheral blood protein signature in IPF components may serve as biomarkers for presence progression. Methods Findings We analyzed the concentrations 49 proteins plasma 74 patients 53 control individuals. identified combinatorial five proteins—MMP7, MMP1, MMP8, IGFBP1, TNFRSF1A—that...
Background Chronic obstructive pulmonary disease (COPD) is a progressive lung characterized by abnormal cellular responses to cigarette smoke, resulting in tissue destruction and airflow limitation. Autophagy degradative process involving lysosomal turnover of components, though its role human diseases remains unclear. Methodology Principal Findings Increased autophagy was observed from COPD patients, as indicated electron microscopic analysis, well increased activation autophagic proteins...
<h3>Importance</h3>Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF), which are based on clinical and physiological parameters, have modest value predicting patients will progress. In addition to the potential for improving prognostic models, identifying genetic molecular features that associated with IPF may provide insight into underlying mechanisms disease inform trials.<h3>Objective</h3>To determine whether MUC5B promoter polymorphism (rs35705950), previously...
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by activation of fibroblasts and overproduction extracellular matrix (ECM). Caveolin-1 (cav-1), principal component caveolae, has been implicated in the regulation numerous signaling pathways biological processes. We observed marked reduction cav-1 expression lung tissues primary from IPF patients compared with controls. also demonstrated that markedly ameliorated bleomycin (BLM)-induced fibrosis, as...
Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology with variable and unpredictable course.The aim this study was to identify validate plasma proteins that are predictive outcome in IPF.Plasma samples were available for 241 patients IPF (140 derivation 101 validation). In the cohort, concentrations 92 analyzed using multiplex bead-based immunoassay matrix metalloproteinase (MMP)-7, MMP-1, surfactant protein D assessed by ELISA. validation cohort intercellular...
Rationale: The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature IPF.Objectives: To understand patterns IPF.Methods: RNA was extracted from 23 stable IPF lungs, 8 lungs with exacerbation (IPF-AEx), and 15 control used for hybridization on Agilent microarrays. Functional analysis genes performed Spotfire Genomica. Gene validations MMP1, MMP7, AGER, DEFA1–3, COL1A2, CCNA2 were by...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the that believed to result from an atypical response injury epithelium. Genome-wide association studies have reported signals implicating multiple pathways including host defense, telomere maintenance, signaling, and cell-cell adhesion.Objectives: To improve our understanding factors increase IPF susceptibility identifying previously unreported genetic associations.Methods: We conducted...
There is an urgent need for improved understanding of the mechanisms and clinical characteristics acute respiratory distress syndrome (ARDS) due to coronavirus disease (COVID-19).
Adaptive immune responses are present in patients with chronic obstructive pulmonary disease (COPD), and it has been postulated that these processes could be autoreactive.
Rationale: Diverse autoantibodies are present in most patients with idiopathic pulmonary fibrosis (IPF). We hypothesized that specific may associate IPF manifestations.Objectives: To identify clinically relevant, antigen-specific immune responses IPF.Methods: Autoantibodies were detected by immunoblots and ELISA. Intrapulmonary processes evaluated immunohistochemistry. Anti–heat shock protein 70 (HSP70) IgG was isolated from plasma immunoaffinity. Flow cytometry used for leukocyte functional...
Abstract Idiopathic pulmonary fibrosis (IPF) is a morbid, refractory lung disorder with an unknown pathogenesis. To investigate potential adaptive immune mechanisms in IPF, we compared phenotypes and effector functions of peripheral CD4 T cells, autoantibody production, proliferative responses hilar lymph node cells to autologous extracts from afflicted patients normals. Our results show that greater proportions lymphocytes IPF subjects expressed MHC class II CD154 (CD40L), they more...
Particulate matter 2.5 μm or less in diameter (PM2.5) is associated with adverse outcomes for patients idiopathic pulmonary fibrosis, but its association other fibrotic interstitial lung diseases (fILDs) and the of PM2.5 composition remain unclear.
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWASs leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study across ancestrally diverse individuals (European, African, Asian, Hispanic/Latino) from NHLBI Trans-Omics Precision Medicine (TOPMed) program. We used whole-genome sequencing (WGS) of whole blood variant genotype calling bioinformatic estimation in n = 109,122...
The biomechanical environment plays a dominant role in fracture healing, and Piezo1 is regarded as major mechanosensor bone homeostasis.However, the of healing not yet well characterized.In this study, we first delineated that highly expressed periosteal stem cells (PSCs) their derived osteoblastic lineage chondrocytes.Furthermore, downregulation callus leads to impaired while activation by its specific agonist promotes through stimulation PSC-modulated chondrogenesis osteogenesis, along...
Cigarette smoke (CS) is the most common risk factor for chronic obstructive pulmonary disease (COPD). The present study aimed to elucidate whether mtDNA released upon CS exposure and detected in plasma of former smokers affected by COPD as a possible consequence airway damage. We measured cell-free (cf-mtDNA) nuclear DNA (cf-nDNA) patient mouse serum with CS-induced emphysema. patients mice emphysema showed increased cf-mtDNA levels. In cell culture, sublethal dose CSE decreased...
Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare, irreversible, and progressive disease of the lungs. Common genetic variants, in addition to nongenetic factors, have been consistently associated with IPF. Rare variants identified by candidate gene, family-based, exome studies also reported associate However, extent which rare genome-wide, may contribute risk IPF remains unknown. Objectives: We used whole-genome sequencing investigate role on risk. Methods: As part Trans-Omics for...
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by limited treatment options and high mortality. A better understanding of the molecular drivers IPF progression needed.
Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)–dependent vascular dysfunction, HIF-2α promoted expression neighboring genes, long noncoding RNA (lncRNA) histone lysine N -methyltransferase 2E-antisense 1 ( KMT2E-AS1 ) N-methyltransferase 2E KMT2E ). stabilized protein to increase epigenetic 3 4 trimethylation (H3K4me3),...
Ventilator-induced lung injury (VILI) leads to an unacceptably high mortality. In this regard, the antiinflammatory properties of inhaled carbon monoxide (CO) may provide a therapeutic option.