A5033382458- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Occupational and environmental lung diseases
- Systemic Sclerosis and Related Diseases
- Pulmonary Hypertension Research and Treatments
- Transplantation: Methods and Outcomes
- Occupational exposure and asthma
- Health Literacy and Information Accessibility
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Pleural and Pulmonary Diseases
- Ocular Diseases and Behçet’s Syndrome
- Neonatal Respiratory Health Research
- Vasculitis and related conditions
- Social Media in Health Education
- Polyomavirus and related diseases
- Frailty in Older Adults
- Sinusitis and nasal conditions
- Research on Leishmaniasis Studies
- Rheumatoid Arthritis Research and Therapies
- Respiratory viral infections research
Vancouver General Hospital
2025
University of Toronto
2016-2025
University of British Columbia
2017-2025
University of Calgary
2021-2025
St. Paul's Hospital
2025
St. Paul's Hospital
2025
Université de Montréal
2025
University Health Network
2014-2025
Libin Cardiovascular Institute of Alberta
2021
Canada Research Chairs
2021
Progressive fibrosing interstitial lung disease (PF-ILD) is characterised by progressive physiological, symptomatic and/or radiographic worsening. The real-world prevalence and characteristics of PF-ILD remain uncertain.Patients were enrolled from the Canadian Registry for Pulmonary Fibrosis between 2015 2020. was defined as a relative forced vital capacity (FVC) decline ≥10%, death, transplantation or any two of: FVC ≥5% <10%, worsening respiratory symptoms fibrosis on computed tomography...
Extent of fibrosis, defined by the amount honeycombing and traction bronchiectasis, was consistently associated with death or lung transplant across all interstitial disease subtypes in a dose-dependent fashion.
Rationale: Patients frequently use YouTube as a platform for dissemination and consumption of health information. Caregivers patients affected by idiopathic pulmonary fibrosis (IPF) are likely consumers this Objectives: We aimed to determine viewer engagement, quality, content videos on IPF compare the provided information with contemporaneous guidelines. Methods: analyzed first 200 resulting from search term "idiopathic fibrosis." Patient-directed containing any were eligible. Each video...
Patients commonly use the Internet as a resource for health information; however, no studies have evaluated online information about idiopathic pulmonary fibrosis (IPF).We sought to determine readability, content (compared with established guidelines), bias, and quality of IPF resources.We analyzed first 200 hits "idiopathic fibrosis" in Google, Yahoo, Bing. Each website was related features treatments that are discussed clinical guidelines. Website assessed using validated DISCERN...
Particulate matter 2.5 μm or less in diameter (PM2.5) is associated with adverse outcomes for patients idiopathic pulmonary fibrosis, but its association other fibrotic interstitial lung diseases (fILDs) and the of PM2.5 composition remain unclear.
Rationale: Cough is a key symptom in patients with fibrotic interstitial lung disease (ILD). Objective: This study evaluated the prevalence, longitudinal change, associations, and prognostic significance of cough severity ILD. Methods: We included consecutive idiopathic pulmonary fibrosis (IPF) non-IPF ILD who completed 100mm-Cough Severity Visual Analog Scale (VAS) from prospective multi-center Canadian Registry for Pulmonary Fibrosis. Baseline associations patient demographics clinical...
The CAnadian REgistry for Pulmonary Fibrosis (CARE-PF) is a multi-center, prospective registry designed to study the natural history of fibrotic interstitial lung disease (ILD) in adults. aim this cross-sectional sub-study was describe baseline characteristics, risk factors, and comorbidities patients enrolled CARE-PF date. Patients completed questionnaires clinical measurements at enrollment each follow-up visit. Environmental exposures were assessed by patient self-report Charlson...
Surgical volume-outcome relationships are well established but have not been studied in patients with interstitial lung disease (ILD) undergoing surgical biopsy (SLB). Our study objective was to determine if hospital SLB volume is associated post-operative mortality ILD.A cohort using administrative, population-based data from Ontario, Canada performed adults ILD who underwent a between 2001 and 2014. The association yearly 30-day assessed multilevel logistic regression modelling.3057...
Abstract Objectives Interstitial lung disease (ILD) in CTDs has highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality, immunosuppression response. Methods Patients with CTD-ILD had high-resolution chest CT (HRCT) reviewed by expert radiologists blinded clinical data for overall pattern [usual interstitial pneumonia (UIP); non-specific (NSIP); organizing (OP); fibrotic hypersensitivity pneumonitis (fHP); other]. Transplant-free...
Background . The relative rarity and diversity of fibrotic interstitial lung disease (ILD) have made it challenging to study these diseases in single-centre cohorts. Here we describe formation a multicentre Canadian registry that is needed the outcomes ILD enable detailed healthcare utilization analyses will be cornerstone for future planning. Methods Registry Pulmonary Fibrosis (CARE-PF) prospective cohort anticipated consist at least 2,800 patients with ILD. CARE-PF used (1) natural...
Sarcoidosis-related mortality appears to be rising in North America, with increasing rates females and the elderly. We aimed estimate trends sarcoidosis incidence, prevalence Ontario, Canada.We performed a cohort study using health administrative data from Ontario between 1996 2015. International Classification of Diseases Health Insurance Plan codes were used for case detection. Three disease definitions created: 1) sarcoidosis, two or more physician claims within 2 years; 2) chronic five 3...
Rationale The European Quality of Life 5-Dimensions 5-Levels questionnaire (EQ-5D-5L) is a multidimensional patient-reported that supports calculation quality-adjusted life-years. Our objectives were to demonstrate feasibility use and calculate the minimum important difference (MID) EQ-5D-5L its associated visual analogue scale (EQ-VAS) in patients with fibrotic interstitial lung disease (ILD). Methods Patients who completed identified from prospective multicentre CAnadian REgistry for...
Rationale: Fibrotic interstitial lung disease (fILD) is a group of pathologic entities characterized by scarring the lungs and high morbidity mortality. Research investigating how socioeconomic residential factors impact outcomes in patients with fILD lacking. Objectives: To determine association between neighborhood-level disadvantage presentation severity, progression, transplantation, mortality from United States Canada. Methods: We performed multicenter, international, prospective cohort...
Pulmonary rehabilitation (PR) benefits individuals with chronic respiratory conditions beyond COPD; however, the quality of online resources has not been evaluated. The aims this study were to assess content, quality, and comprehensibility YouTube videos that provide PR lung diseases other than COPD. A search was conducted on for related non-COPD conditions, first 350 screened eligibility (2004-2024). Videos assessed content based predefined scoring matrix derived from guidelines, evaluated...
Background The epidemiology of adult interstitial lung disease (ILD) is uncertain, given heterogeneous estimates from prior studies. objective this study was to define the incidence, prevalence, and mortality ILD over a 10-year period using population-based data. Methods We created an administrative cohort in Alberta, Canada between 2010-2019 data (inpatient, ambulatory, outpatient physician billing databases) for repeat cross-sectional study. Case definitions were developed established...
The interstitial lung disease (ILD) specialists in Vancouver participate a multidisciplinary discussion (MDD) that is primarily used internally for patients seen by these specialists. MDD also remotely (externally) general pulmonologists to increase access this service.To describe the impact of an on diagnosis and management ILD two patient cohorts, report satisfaction referring with service.This retrospective cross-sectional study included who underwent review between March 2014 June 2017....
Background Little is known about generalisability of randomised controlled trials (RCTs) for idiopathic pulmonary fibrosis (IPF). We evaluated eligibility criteria phase III IPF RCTs to determine their representativeness in clinical registries, and calculated forced vital capacity (FVC) changes according criteria. Methods Common used >60% were identified from a literature search applied patients with prospective Australian Canadian registries. Additional pre-specified 6-min walk distance...
Abstract Background and objective Inhalational exposures are a known cause of interstitial lung disease (ILD), but little is understood about their prevalence across ILD subtypes relationship with pulmonary function survival. Methods Patients fibrotic were identified from the multicentre Canadian Registry for Pulmonary Fibrosis. completed questionnaires regarding ILD‐related occupational environmental exposures. The between outcomes baseline age, gender, family history, survival was analysed...
Individuals with lung disease commonly use the internet as a source of health information on pulmonary rehabilitation (PR). The objective this study was to characterize resources PR, and assess content, readability, quality patient-directed PR resources.The first 200 websites for search term 'pulmonary exercise' were analyzed Google, Yahoo, Bing. Website content assessed based 30 key components from 2013 2021 international consensus statements. determined using DISCERN, JAMA benchmarks,...
BACKGROUND: Portopulmonary hypertension is associated with significant morbidity and mortality. Phosphodiesterase‐5 inhibitor therapy efficacious in other causes of WHO group I pulmonary arterial hypertension. OBJECTIVE: To evaluate the efficacy safety phosphodiesterase‐5 patients portopulmonary METHODS: A single‐centre retrospective cohort study that included a diagnosis was performed. The primary outcome change vascular resistance after six months therapy. secondary evaluation investigated...