A5080227095- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Occupational and environmental lung diseases
- Frailty in Older Adults
- Medical Imaging and Pathology Studies
- Diabetes and associated disorders
- Pain Mechanisms and Treatments
- Diabetes Management and Research
- Parkinson's Disease Mechanisms and Treatments
- Systemic Sclerosis and Related Diseases
- Respiratory Support and Mechanisms
- Heart Rate Variability and Autonomic Control
- Diabetes Management and Education
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Sarcoidosis and Beryllium Toxicity Research
- Botulinum Toxin and Related Neurological Disorders
- Diabetes Treatment and Management
- Cardiovascular Health and Risk Factors
- Inflammatory Myopathies and Dermatomyositis
- Ferroptosis and cancer prognosis
- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
University of Kansas Medical Center
2024
Lady Reading Hospital
2024
McMaster University
2018-2022
St. Joseph’s Healthcare Hamilton
2020-2021
Lunenfeld-Tanenbaum Research Institute
2015-2018
Mount Sinai Hospital
2015-2018
Hamilton Health Sciences
2018
Population Health Research Institute
2018
University of Toronto
2015-2018
University of Pittsburgh
2004
Progressive fibrosing interstitial lung disease (PF-ILD) is characterised by progressive physiological, symptomatic and/or radiographic worsening. The real-world prevalence and characteristics of PF-ILD remain uncertain.Patients were enrolled from the Canadian Registry for Pulmonary Fibrosis between 2015 2020. was defined as a relative forced vital capacity (FVC) decline ≥10%, death, transplantation or any two of: FVC ≥5% <10%, worsening respiratory symptoms fibrosis on computed tomography...
Background Frailty is associated with higher mortality in individuals at high cardiovascular disease (CVD) risk. We hypothesize that frailty a more important prognostic factor than CVD risk factors and aim to determine the value of cumulative deficit index patients or for CVD. Methods Results conducted an individual-level pooled analysis participants CVD, recruited 14 multicenter clinical trials. The was calculated as proportion 26 deficits exhibited. Individuals were categorized nonfrail,...
BACKGROUND. In type 1 diabetes (T1D), adjuvant treatment with inhibitors of the renin-angiotensin-aldosterone system (RAAS), which dilate efferent arteriole, is associated prevention progressive albuminuria and renal dysfunction. Uncertainty still exists as to why some individuals long-standing T1D develop diabetic kidney disease (DKD) while others do not (DKD resistors). We hypothesized that those DKD would be distinguished from resistors by presence RAAS activation.
In vivo Corneal Confocal Microscopy (IVCCM) is a validated, non-invasive test for diabetic sensorimotor polyneuropathy (DSP) detection, but its utility limited by the image analysis time and expertise required. We aimed to determine inter- intra-observer reproducibility of novel automated program compared manual analysis.In cross-sectional diagnostic study, 20 non-diabetes controls (mean age 41.4±17.3y, HbA1c 5.5±0.4%) 26 participants with type 1 diabetes (42.8±16.9y, 8.0±1.9%) underwent two...
Objectives To estimate the prevalence and awareness of risk factors behaviours coronary heart disease (CHD) in lower middle class residing urban localities Karachi, a mega city Pakistan
The capacity to exercise is a major contributor functional limitation and accompanied by increased morbidity mortality. What are the most important physiological contributors capacity? Cross-sectional data from consecutive patients referred McMaster University Medical Centre laboratory for incremental cardiopulmonary testing 1988 2012 were analysed. Exercise was determined maximal power output (MPO) in kpm·min-1. contributions of quadriceps strength (maximal peak force kg using dynamic...
Abstract Background and objective Physical frailty is associated with increased mortality hospitalizations in older adults. We describe the prevalence of physical its prognostic impact patients a spectrum fibrotic interstitial lung disease (ILD). Methods Patients ILD at McMaster University programme were prospectively followed up from November 2015 to March 2020. Baseline data used classify as non‐frail (score = 0), pre‐frail 1–2) or frail 3–5) based on modified Fried criteria. The...
Background Low lung function is associated with high mortality and adverse cardiopulmonary outcomes. Less known of its association broader health indices such as self-reported respiratory symptoms, perceived general health, cognitive physical performance. The present study seeks to address the between forced expiratory volume in 1 second (FEV ), an indicator function, broad markers relevant aging trajectory population. Methods findings From Canadian population, 22,822 adults (58% females,...
Introduction To examine the prevalence of chronic obstructive pulmonary disease (COPD) misclassification and associated burden symptoms, healthcare utilisation physical performance status in Canadian general population. This information is presently lacking from large population-based studies with high-quality spirometry data that can be generalised to Methods The self-reported physician-diagnosed COPD concordance airflow obstruction (AO) were assessed a cross-sectional cohort older adults....
This study investigates the prevalence of Giardia lamblia across different tehsils, genders, age groups, and healthcare facilities in District Swat, Pakistan. A total 14,732 patients were analyzed, out which 5,641 (38.3%) tested positive for lamblia. The highest tehsil-wise was observed Babozai (59%), followed by Khwazakhela (43.1%), while Kalam recorded lowest (10%). Gender-wise, males showed a significantly higher (59.4%) compared to females (19.3%), reflecting potential differences...
Chronic liver disease (CLD) contributes significantly to morbidity and mortality around the world. In Pakistan, it is due mainly infections of Hepatitis B C. One complications CLD, which often important for such patients, involves an infection spontaneous bacterial peritonitis. Asymptomatic peritonitis commonly develops in asymptomatic patients with ascites therefore preventable when early. This study will determine incidence SBP CLD ascites, providing potentially valuable data support...
Stridor is an uncommon presentation for Parkinson’s disease dystonia. We report a case of 68-year-old female with poorly controlled who presented to the hospital recurrent episodes respiratory distress and stridor. Aggressive management her disease, including insertion deep brain stimulator, led resolution these episodes.