A5111783631- Chronic Lymphocytic Leukemia Research
- Prostate Cancer Treatment and Research
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Respiratory Support and Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Lymphoma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Osteoarthritis Treatment and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Genomics and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Breast Cancer Therapies
- Cancer survivorship and care
- Health Promotion and Cardiovascular Prevention
- Inflammatory mediators and NSAID effects
- Prostate Cancer Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Hematopoietic Stem Cell Transplantation
- Genetic factors in colorectal cancer
- Alcoholism and Thiamine Deficiency
- Hemoglobinopathies and Related Disorders
- Musculoskeletal pain and rehabilitation
- Blood groups and transfusion
- Genetic and rare skin diseases.
Tianjin Medical University
2025
Alector (United States)
2025
Zhoushan Hospital
2024
Orthopedic Institute
2024
Gilead Sciences (United States)
2017-2023
Hematology Oncology Associates
2023
Lakeridge Health
2022
NYU Langone’s Laura and Isaac Perlmutter Cancer Center
2021
Winthrop-University Hospital
2020
Cornell University
2012-2015
A randomized, double-blind, phase III study of idelalisib (IDELA) plus rituximab versus placebo in patients with relapsed chronic lymphocytic leukemia (CLL) was terminated early because superior efficacy the IDELA-plus-rituximab (IDELA/R) arm. Patients either arm could then enroll an extension to receive IDELA monotherapy. Here, we report long-term and safety data for IDELA-treated across primary studies.Patients were randomly assigned combination 150 mg twice daily (IDELA/R; n = 110) or...
Genomic instability is a fundamental feature of human cancer often resulting from impaired genome maintenance. In prostate cancer, structural genomic rearrangements are common mechanism driving tumorigenesis. However, somatic alterations predisposing to chromosomal in remain largely undefined. Here, we show that SPOP , the most commonly mutated gene primary modulates DNA double strand break (DSB) repair, and mutation associated with instability. vivo, results transcriptional response...
Osteoarthritis (OA) is a prevalent degenerative joint disease, especially occur in the elderly. This study aimed to uncover novel biomarker for early diagnosis and treatment of OA. WGCNA, differential expression analysis PPI network were used screening hub genes-related OA, utilizing GSE55235 GSE57218 datasets from GEO database. Based on data datasets, compared normal tissues, ITGB5 was obviously elevated OA cartilage synovial samples. Additionally, ROC curve results validated diagnostic...
Copy number variants (CNVs) are a recently recognized class of human germ line polymorphisms and associated with variety diseases, including cancer. Because the strong genetic influence on prostate cancer, we sought to identify functionally active CNVs susceptibility this cancer type. We queried low-frequency biallelic from 1,903 men Caucasian origin enrolled in Tyrol Prostate Specific Antigen Screening Cohort discovered two strongly risk. The first risk locus ( P = 7.7 × 10 −4 , odds ratio...
Abstract Approximately 5% to 15% of acute myeloid leukemia (AML) patients have TP53 gene mutations ( m), which are associated with very poor outcomes. Adults (≥18 years) a new AML diagnosis were included from nationwide, de‐identified, real‐world database. Patients receiving first‐line therapy divided into three cohorts: venetoclax (VEN) + hypomethylating agents (HMAs; Cohort A), intensive chemotherapy (Cohort B), or HMA without VEN C). A total 370 newly diagnosed m (n = 124), chromosome 17p...
Previous studies have suggested that women with cardiovascular disease may receive less aggressive care than men. Using a large cardiology database from tertiary referral center, we sought to determine if treatment differences still persist in the current era.We analyzed data on 2462 patients who were referred for secondary prevention Preventive Cardiology Clinic at The Cleveland Foundation between 1997 and 2004. primary objective was evaluate use of effective preventive therapies, by...
Summary Comorbidities influence survival in patients with chronic lymphocytic leukaemia (CLL) treated chemo‐immunotherapy or ibrutinib. While idelalisib has been studied comorbidities, their impact not investigated. We analysed 481 on two randomised trials (NCT01659021 and NCT01539512). were assessed using the Cumulative Illness Risk Scale (CIRS). Patients received + anti‐CD20 (rituximab ofatumumab; n = 284) alone ( 197). The median age was 69 years. found that comorbidities did...
The CLL-IPI is a risk-weighted prognostic model for previously untreated patients with chronic lymphocytic leukemia (CLL), but has not been evaluated in relapsed CLL or on novel therapies. We the 897 relapsed/refractory 3 randomized trials testing idelalisib (PI3Kδ inhibitor). identified as low (2.2%), intermediate (12.8%), high (48.7%), and very (36.2%) risk was survival (log-rank p < .0001; C-statistic 0.706). Of factors, age >65, β2-microglobulin >3.5mg/L, unmutated immunoglobulin heavy...
Background Low lung function is associated with high mortality and adverse cardiopulmonary outcomes. Less known of its association broader health indices such as self-reported respiratory symptoms, perceived general health, cognitive physical performance. The present study seeks to address the between forced expiratory volume in 1 second (FEV ), an indicator function, broad markers relevant aging trajectory population. Methods findings From Canadian population, 22,822 adults (58% females,...
Abstract Trial Information Lessons Learned Although this study of idelalisib in patients with PDAC was limited size and duration because early termination, exposure resulted an overall safety profile consistent studies hematological malignancies, except that the incidences diarrhea colitis were reduced PDAC. Preclinical PI3K pathway positive clinical results inhibition other cancers support continued development inhibitors Background Pancreatic ductal adenocarcinoma (PDAC) is among most...
Introduction To examine the prevalence of chronic obstructive pulmonary disease (COPD) misclassification and associated burden symptoms, healthcare utilisation physical performance status in Canadian general population. This information is presently lacking from large population-based studies with high-quality spirometry data that can be generalised to Methods The self-reported physician-diagnosed COPD concordance airflow obstruction (AO) were assessed a cross-sectional cohort older adults....
Despite advances in ablation and other therapies for AF, progression of atrial fibrillation (AF) remains a significant clinical problem, associated with worse prognosis treatment outcomes. Upstream targeting inflammatory or antifibrotic mechanisms have been disappointing preventing AF progression, but more recently genetic genomic studies suggest novel cellular metabolic stress targets, supporting prior lifestyle risk factor modification (LRFM) AF. However, while obesity is factor, weight...
This study investigated the etiology, clinical features, and management of acute hydrogen sulfide (H
Abstract Background: Genomic instability is a fundamental feature of human cancer, and DNA repair defects resulting in impaired genome maintenance promote pathogenesis many types cancers. In prostate structural genomic rearrangements, including translocations copy number aberrations, are key mechanism driving tumorigenesis. Recently, whole sequencing revealed striking abundance, complexity, heterogeneity potentially suggesting distinct mechanisms different molecular classes cancer. However,...