A5058778822- Diabetes Treatment and Management
- Diabetes Management and Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Pancreatic function and diabetes
- Lipoproteins and Cardiovascular Health
- Diabetes and associated disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Cardiac Health and Mental Health
- Pharmacology and Obesity Treatment
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Peripheral Artery Disease Management
- Health Systems, Economic Evaluations, Quality of Life
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Inhalation and Respiratory Drug Delivery
- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
Cleveland Clinic
2005-2023
Central Michigan University
2020-2023
Eli Lilly (United States)
2009-2020
Dallas Diabetes Research Center
2011
University of North Carolina at Chapel Hill
2011
Park Nicollet Clinic
2011
University of Minnesota
1983-2009
General Department of Preventive Medicine
2009
Twin Cities Orthopedics
2009
Calvin University
2009
Background: Insulin replacement in diabetes often requires prandial intervention to reach hemoglobin A1c (HbA1c) targets. Objective: To test whether twice-daily exenatide injections reduce HbA1c levels more than placebo people receiving insulin glargine. Design: Parallel, randomized, placebo-controlled trial, blocked and stratified by level at site, performed from October 2008 January 2010. Participants, investigators, personnel conducting the study were masked treatment assignments....
OBJECTIVE Intensive therapy targeting normal blood glucose increased mortality compared with standard treatment in a randomized clinical trial of 10,251 participants type 2 diabetes at high-risk for cardiovascular disease (CVD) events. We evaluated whether the presence cardiac autonomic neuropathy (CAN) baseline modified effect intensive glycemia on outcomes Action to Control Cardiovascular Risk Diabetes (ACCORD) participants. RESEARCH DESIGN AND METHODS CAN was assessed by measures heart...
Background: Exenatide therapy is effective in combination with metformin or sulfonylureas for treating type 2 diabetes. Thiazolidinediones (TZDs) also are commonly used, but the efficacy of exenatide a TZD has not been reported. Objective: To compare effects versus placebo on glycemic control. Design: Placebo run-in, randomized, double-blind, placebo-controlled trial conducted from May 2004 to August 2005. Setting: 49 sites Canada, Spain, and United States. Patients: 233 (exenatide group, n...
To examine whether the form of dietary carbohydrate influences glucose and insulin responses, we studied responses to five meals--each containing a different but all with nearly identical amounts total carbohydrate, protein, fat--in 10 healthy subjects, 12 patients Type I diabetes, II diabetes. The test carbohydrates were glucose, fructose, sucrose, potato starch, wheat starch. In three groups, meal sucrose as did not produce significantly greater peak increments in plasma concentration or...
OBJECTIVE To test the hypothesis that exenatide twice daily reduces relative incidence of cardiovascular disease (CVD) events among patients with type 2 diabetes compared other glucose-lowering agent(s). RESEARCH DESIGN AND METHODS A retrospective database analysis was performed LifeLink medical and pharmaceutical insurance claims for June 2005 through March 2009. Patients no history in preceding 9 months myocardial infarction, ischemic stroke, or coronary revascularization procedure were...
OBJECTIVE Mealtime insulin is commonly added to manage hyperglycemia in type 2 diabetes when basal insufficient. However, this complex regimen associated with weight gain and hypoglycemia. This study compared the efficacy safety of exenatide twice daily or mealtime lispro patients inadequately controlled by glargine metformin despite up-titration. RESEARCH DESIGN AND METHODS In 30-week, open-label, multicenter, randomized, noninferiority trial 12 weeks prior optimization, 627 insufficient...
Background —The Post Coronary Artery Bypass Graft Trial, designed to compare the effects of 2 lipid-lowering regimens and low-dose anticoagulation versus placebo on progression atherosclerosis in saphenous vein grafts patients who had CABG surgery, demonstrated that aggressive lowering LDL cholesterol (LDL-C) levels <100 mg/dL compared with a moderate reduction 132 136 decreased grafts. Low-dose did not significantly affect progression. Methods Results —Approximately 3 years after last...
Abstract Objective Uric acid is a product of the activity xanthine oxidase, an enzyme linked to oxidative stress, endothelial dysfunction, and heart failure. It unclear whether adding uric levels assessment cardiovascular risk might contribute improved ability stratify risk. The purpose this study was evaluate prognostic value serum in large cohort men women at high disease. Methods Serum were determined all patients seen for primary/secondary disease prevention Cleveland Clinic Section...
OBJECTIVE Foot ulceration remains a major health problem for diabetic patients and has impact on the cost of diabetes treatment. We tested hyperspectral imaging technology that quantifies cutaneous tissue hemoglobin oxygenation generated anatomically relevant maps to assess healing potential foot ulcers (DFUs). RESEARCH DESIGN AND METHODS A prospective single-arm blinded study was completed in which 66 with type 1 2 were enrolled followed over 24-week period. Clinical, medical, histories...
We investigated non-alcoholic fatty liver disease (NAFLD) prevalence and its metabolic associations in patients with type 1 diabetes (T1D), insulin-naïve insulin-treated 2 (T2D). Baseline data from who had fat content (LFC) evaluated by magnetic resonance imaging four phase 3 studies of basal insulin peglispro (BIL) were analysed. Associations NAFLD clinical characteristics, glycaemic control therapy evaluated. The (defined as LFC ≥ 6%) was low T1D (8.8%) but high T2D, greater (75.6%) vs...
Thyroid hormones have profound effect on the heart and peripheral vasculature. Hypothyroidism is associated with an increase in a number of coronary disease (CHD) risk factors including dyslipidemia, hypertension, elevated levels homocysteine. Our objective was to assess effects hypothyroidism (thyroid-stimulating hormone [TSH]: >10 μ U/mL), moderate subclinical (SCH; TSH: 6.1-10 mild SCH (TSH: 3.1-6.0 U/mL) cardiovascular factors, CHD prevalence, all-cause mortality patients at high for...
The BMI is the most frequently used marker to evaluate obesity-associated risks. An alternative continuous index of lipid over accumulation, accumulation product (LAP), has been proposed, which computed from waist circumference (WC, cm) and fasting triglycerides (TGs) (mmol/l): (WC - 65) x TG (men) 58) (women). We evaluated LAP as predictors mortality in a high-risk cohort. Study population included 5,924 new consecutive patients seen between 1995 2006 at preventive cardiology clinic....
Abstract Background Cardiovascular effects of glucose-lowering agents are increasing interest. Our aim was to assess the glucagon-like peptide-1 receptor agonist exenatide on heart rate (HR) and blood pressure (BP) in subjects with type 2 diabetes mellitus (T2DM). Methods In this double-blind, placebo-controlled trial, T2DM metformin and/or a thiazolidinedione were randomized receive (5 μg for 4 weeks followed by 10 μg) or placebo BID 12 weeks. Heart BP assessed 24-hour ambulatory...
Examine the association between obesity and glycemic control among patients with type 1 (T1DM) or 2 diabetes mellitus (T2DM).Data from US physician electronic health records (Humedica®) 2009-2011 were utilized. Patients defined as having above-target if they had an HbA1c ≥7% at any time during study period. Multinomial logistic regressions conducted separately for T1DM T2DM patients, examined associations BMI categories probability of (≥7% <8%, ≥8% <9%, ≥9%) while controlling patient...
Diabetes is associated with abnormal autonomic function and increased mortality. Abnormal heart rate recovery after exercise, a measure of dysfunction, also The objective this study was to determine the association fasting plasma glucose its prognostic importance in healthy adults. We studied 5,190 adults who did not have medically treated diabetes (mean age 45 years, 39% women), were enrolled Lipid Research Clinics’ Prevalence Study, underwent exercise testing. Heart defined as change from...