A5006688566- Heart Failure Treatment and Management
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Cardiac Valve Diseases and Treatments
- Adipose Tissue and Metabolism
- Cardiac Arrhythmias and Treatments
- Islamic Finance and Banking Studies
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Organ and Tissue Transplantation Research
- Socioeconomic Development in MENA
- Heart Rate Variability and Autonomic Control
- Cardiovascular and exercise physiology
- Cardiac Arrest and Resuscitation
- Cardiac Imaging and Diagnostics
- Diabetes Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Erythropoietin and Anemia Treatment
Case Western Reserve University
2016-2025
Cleveland Clinic Lerner College of Medicine
2016-2025
Cleveland Clinic
2015-2024
Allama Iqbal Open University
2022-2024
National Open University
2022-2024
University of Naples Federico II
2024
Adana Science and Technology University
2024
Universiti Putra Malaysia
2024
University of San Jose–Recoletos
2023-2024
Guangdong University of Technology
2024
Classifications of heart muscle diseases have proved to be exceedingly complex and in many respects contradictory. Indeed, the precise language used describe these is profoundly important. A new contemporary rigorous classification cardiomyopathies (with definitions) proposed here. This reference document affords an important framework measure clarity this heterogeneous group diseases. Of particular note, present scheme recognizes rapid evolution molecular genetics cardiology, as well...
Cardiac resynchronization therapy (CRT) through biventricular pacing is an effective treatment for heart failure (HF) with a wide QRS; however, the outcomes of patients requiring CRT and implantable cardioverter defibrillator (ICD) are unknown.To examine efficacy safety combined ICD in New York Heart Association (NYHA) class III or IV congestive HF despite appropriate medical management.Randomized, double-blind, parallel-controlled trial conducted from October 1, 1999, to August 31, 2001,...
Recent studies indicate a link between carbohydrate intake and the functional state of sympathetic nervous system. Fasting or restriction decreases activity, while glucose ingestion dietary supplementation with sucrose increases nerve activity. To examine potential contributions hyperglycemia hyperinsulinemia to stimulation, activity was assessed by measurement plasma norepinephrine (NE) levels concomitant cardiovascular indices in nonobese young men during insulin infusions using clamp...
Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that produces negative inotropic effects in the heart. Recently, elevated levels of TNF-alpha have been reported patients with advanced congestive heart failure. Although thought to exert its deleterious by binding two cell surface receptors, TNFR1 and TNFR2, level expression regulation TNF receptors cardiac disease states not known.We examined mRNA protein for TNFR1, explanted hearts from organ donors as well end-stage...
Background —Previous reports have shown that elevated circulating levels of cytokines and/or cytokine receptors predict adverse outcomes in patients with heart failure. However, these studies were limited by small numbers they performed a single center. In addition, did not sufficient size to address the influence age, race, sex, and cause failure on inflammatory mediators Methods Results —We analyzed (tumor necrosis factor [TNF] interleukin-6) their cognate 1200 consecutive who enrolled...
The association between systolic blood pressure (SBP) at admission, clinical characteristics, and outcomes in patients hospitalized for heart failure who have reduced or relatively preserved function has not been well studied.To evaluate the relationship SBP profile, acute failure.Cohort study using data from Organized Program to Initiate Lifesaving Treatment Hospitalized Patients with Heart Failure (OPTIMIZE-HF) registry performance-improvement program 259 US hospitals March 2003 December...
Background —We investigated the effects of candesartan (an angiotensin II antagonist) alone, enalapril and their combination on exercise tolerance, ventricular function, quality life (QOL), neurohormone levels, tolerability in congestive heart failure (CHF). Methods Results —Seven hundred sixty-eight patients New York Heart Association functional class (NYHA-FC) to IV with ejection fraction (EF) <0.40 a 6-minute walk distance (6MWD) <500 m received either (4, 8, or 16 mg), (4 8 mg)...
Introduction: Although numerous trials have shown benefit of implantable cardioverter defibrillators (ICDs) for either primary or secondary prevention, no trial has prospectively enrolled patients from both indications and analyzed ICD utilization between groups. Methods Results: We performed a retrospective review MIRACLE ICD, randomized, prospective double‐blind cardiac resynchronization therapy (CRT) in the population. Both prevention (N = 563) 415) were enrolled. Subgroup analysis...
Although digoxin is effective in the treatment of patients with chronic heart failure who are receiving diuretic agents, it not clear whether drug has a role when angiotensin-converting-enzyme inhibitors, as often case current practice.
Eosinophilic asthma is a phenotype of characterized by the persistence eosinophils in airways. IL-5 involved activation and survival eosinophils.To evaluate effect antibody to IL-5, reslizumab, patients with eosinophilic that poorly controlled high-dose inhaled corticosteroid.Patients were randomly assigned receive infusions reslizumab at 3.0 mg/kg (n = 53) or placebo baseline Weeks 4, 8, 12, stratification Asthma Control Questionnaire (ACQ) score less than equal 2 greater 2. The primary...
Most of our knowledge about atherosclerosis at young ages is derived from necropsy studies, which have inherent limitations. Detailed, in vivo data on individuals are limited. Intravascular ultrasonography provides a unique opportunity for characterization early clinically relevant context.Intravascular ultrasound was performed 262 heart transplant recipients 30.9+/-13.2 days after transplantation to investigate coronary arteries asymptomatic subjects. The donor population consisted 146 men...
To determine whether the risk of adverse cardiovascular (CV) outcomes associated with diabetes differs in patients low and preserved ejection fraction (EF) heart failure (HF). We analysed Candesartan Heart failure—Assessment Reduction Mortality morbidity (CHARM) programme which randomized 7599 symptomatic HF a broad range EF. The prevalence was 28.3% EF (>40%) 28.5% those (≤40%). Diabetes greater relative CV death or hospitalization [hazard ratio (HR) 2.0 (1.70–2.36)] than [HR 1.60...
Background— Patients with chronic heart failure (HF) are at increased risk of both fatal and nonfatal major adverse cardiovascular events. We used data from the Candesartan in Heart failure: Assessment Reduction Mortality morbidity (CHARM) trials to assess influence hospitalizations for HF on subsequent mortality rates a broad spectrum patients. Methods Results— In present study, 7599 patients New York Association class II IV reduced or preserved left ventricular ejection fraction were...
Background— About half of the 5 million heart failure patients in United States have diastolic (clinical with normal or near-normal ejection fraction). Except for candesartan, no drugs been tested randomized clinical trials these patients. Although digoxin was an appreciable number Digitalis Investigation Group ancillary trial, detailed findings from this important study not previously published. Methods and Results— Ambulatory chronic (n=988) sinus rhythm fraction >45% (median, 53%)...
The effects of cardiac resynchronization therapy (CRT) in patients with mildly symptomatic heart failure have not been fully elucidated.The Multicenter InSync ICD Randomized Clinical Evaluation II (MIRACLE II) was a randomized, double-blind, parallel-controlled clinical trial CRT NYHA class on optimal medical left ventricular (LV) ejection fraction < or =35%, QRS > =130 ms, and I indication for an ICD. One hundred eighty-six were randomized: 101 to the control group (ICD activated, off) 85...