A5011794653- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Potassium and Related Disorders
- Blood Pressure and Hypertension Studies
- Health Systems, Economic Evaluations, Quality of Life
- Health Policy Implementation Science
- Healthcare Policy and Management
- Primary Care and Health Outcomes
- Hormonal Regulation and Hypertension
- Dialysis and Renal Disease Management
- Advanced Causal Inference Techniques
- Diabetes Management and Education
- Diabetes Treatment and Management
- Multiple Sclerosis Research Studies
- Epilepsy research and treatment
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Medication Adherence and Compliance
- Cardiac electrophysiology and arrhythmias
- Advanced Statistical Process Monitoring
- Global Health Workforce Issues
- Health disparities and outcomes
- Geriatric Care and Nursing Homes
- Obesity, Physical Activity, Diet
- Cardiac Imaging and Diagnostics
Case Western Reserve University
2015-2024
MetroHealth Medical Center
2012-2024
MetroHealth
2011-2024
HealthPartners
2024
Ohio University
2023
National Health and Medical Research Council
2023
The University of Sydney
2023
The Ohio State University Wexner Medical Center
2023
Cleveland Clinic
2006-2018
University School
2012-2018
Background— About half of the 5 million heart failure patients in United States have diastolic (clinical with normal or near-normal ejection fraction). Except for candesartan, no drugs been tested randomized clinical trials these patients. Although digoxin was an appreciable number Digitalis Investigation Group ancillary trial, detailed findings from this important study not previously published. Methods and Results— Ambulatory chronic (n=988) sinus rhythm fraction >45% (median, 53%)...
Aims Non-potassium-sparing diuretics are commonly used in heart failure (HF).They activate the neurohormonal system, and potentially harmful.Yet, long-term effects of chronic diuretic use HF largely unknown.We retrospectively analysed Digitalis Investigation Group (DIG) data to determine on outcomes.Methods results Propensity scores for were calculated each 7788 DIG participants using a non-parsimonious multivariable logistic regression model, match 1391 (81%) no-diuretic patients with...
Aims To determine the effects of digoxin on all-cause mortality and heart failure (HF) hospitalizations, regardless ejection fraction, accounting for serum concentration (SDC). Methods results This comprehensive post-hoc analysis randomized controlled Digitalis Investigation Group trial (n=7788) focuses 5548 patients: 1687 with SDC, drawn randomly at 1 month, 3861 placebo patients, alive month. Overall, 33% died 31% had HF hospitalizations during a 40-month median follow-up. Compared...
Factors that determine renal function after partial nephrectomy are not well-defined, including the impact of cold vs warm ischemia, and relative importance modifiable nonmodifiable factors. We studied these determinants in a large cohort patients with solitary functioning kidney undergoing nephrectomy.From 1980 to 2009, 660 nephrectomies were performed at 4 centers for tumor under (300) or (360) ischemia. Data collected institutional review board approved registries followup averaged 4.5...
Available studies have shown few quality-related advantages of electronic health records (EHRs) over traditional paper records. We compared achievement and improvement in quality standards for diabetes at practices using EHRs with those All practices, including many safety-net primary care belonged to a regional collaborative publicly reported performance.
High dietary phosphorus intake has deleterious consequences for renal patients and is possibly harmful the general public as well. To prevent hyperphosphatemia, with end-stage disease limit their of foods that are naturally high in phosphorus. However, phosphorus-containing additives increasingly being added to processed fast foods. The effect such on serum levels unclear.To determine limiting food among disease.Cluster randomized controlled trial at 14 long-term hemodialysis facilities...
Background— Little is known about the effects of hypokalemia on outcomes in patients with chronic heart failure (HF) and kidney disease. Methods Results— Of 7788 HF Digitalis Investigation Group trial, 2793 had disease, defined as estimated glomerular filtration rate <60 mL/min per 1.73 m 2 . these, 527 (serum potassium <4 mEq/L; mild) 2266 normokalemia (4 to 4.9 mEq/L). Propensity scores for were used assemble a balanced cohort 522 pairs normokalemia. All-cause mortality occurred 48%...
To demonstrate the potential of de-identified clinical data from multiple healthcare systems using different electronic health records (EHR) to be efficiently used for very large retrospective cohort studies.
Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe individuals is due to aging, and independent of duration.This a cross-sectional study prospectively collected data from participants (N=1130; 454 with asthma) enrolled 2002 - 2011 Asthma Research Program.The association between age probability asthma, which was performed by applying Locally Weighted Scatterplot Smoother, revealed an inflection point at 45 asthma. The increased each year...
The aim was to compare the outcomes of subdural electrode (SDE) implantations versus stereotactic electroencephalography (SEEG), 2 predominant methods intracranial (iEEG) performed in difficult-to-localize drug-resistant focal epilepsy.
Background: Although health is influenced by an individual's characteristics and choices, accumulating evidence suggests that contextual attributes may influence a variety of outcomes. Whether these factors also represent “upstream” affecting one's ability to enter the healthcare system less clear, however. Objective: The objective this study was assess associations between report having usual source care. Research Design: Cross-sectional, survey-weighted data assessing demographics,...
The association between isolated systolic hypertension (ISH) and incident heart failure (HF) has not been prospectively studied in a propensity-matched population of ambulatory older adults. Of the 5795 participants public-use copy Cardiovascular Health Study data set, 5248 had diastolic blood pressure <90 mm Hg were free HF at baseline. these, 2000 (38%) ISH, defined as average seated ≥140 Hg. Propensity scores for baseline ISH calculated each participant (based on 64 covariates) used to...