A5069851935- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Fetal and Pediatric Neurological Disorders
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Neonatal and fetal brain pathology
- Cerebrospinal fluid and hydrocephalus
- Neural dynamics and brain function
- Glioma Diagnosis and Treatment
- Vascular Malformations Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Sleep and Wakefulness Research
- Advanced Neuroimaging Techniques and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Genetics and Neurodevelopmental Disorders
- Memory and Neural Mechanisms
- Metabolism and Genetic Disorders
- Genomics and Rare Diseases
- Ion channel regulation and function
- Vestibular and auditory disorders
- Spinal Dysraphism and Malformations
- Neurobiology of Language and Bilingualism
Ospedale Maggiore
2001-2025
University of Sassari
2025
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2014-2024
Fondazione IRCCS Istituto Neurologico Carlo Besta
2001-2024
Società Italiana di Reumatologia
2018-2024
Azienda Socio Sanitaria Territoriale Lariana
2023
Azienda Ospedaliero-Universitaria di Modena
2022
Foundation Center
2022
University of Pavia
2022
University of Genoa
1997-2022
Purpose: Focal cortical dysplasias (FCD) are localized regions of malformed cerebral cortex and very frequently associated with epilepsy in both children adults. A broad spectrum histopathology has been included the diagnosis FCD. An ILAE task force proposes an international consensus classification system to better characterize specific clinicopathological FCD entities. Methods: Thirty-two Task Force members have reevaluated available data on electroclinical presentation, imaging,...
Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy.We report diagnoses made basis of resected specimens from 9523 patients who underwent epilepsy surgery in 36 centers 12 European countries over 25 years. Histopathological were determined through examination local hospitals (41%) or at German Neuropathology Reference Center Epilepsy Surgery (59%).The onset occurred before 18 years age 75.9%...
Since the original description by Taylor, term focal cortical dysplasia has been used to refer a wide range of alterations mantle. More recently, these conditions have described from neuroimaging, neuropathological and genetic standpoints, generating several classifications. It is widely recognized that classifications are unsatisfactory. We propose simplified classification dysplasias based on easily characteristics. retrospectively re-examined histological sections cortex 52 224 (23%)...
Summary Many patients with medically refractory epilepsy now undergo successful surgery based on noninvasive diagnostic information, but intracranial electroencephalography ( IEEG ) continues to be used as increasingly complex cases are considered surgical candidates. The indications for and the modalities employed vary across centers; each modality has its advantages limitations. can performed in same intraoperative setting, that is, electrocorticography, or through an independent...
This retrospective description of a surgical series is aimed at reporting on indications, methodology, results seizures, outcome predictors and complications from 20-year stereoelectroencephalography (SEEG) activity performed single epilepsy surgery centre. Prospectively collected data consecutive 742 SEEG procedures carried out 713 patients were reviewed described. Long-term seizure SEEG-guided resections was defined as binomial variable: absence (ILAE classes 1-2) or recurrence 3-6)...
To report on indications, surgical technique, results, and morbidity of stereoelectroencephalography (SEEG) in the presurgical evaluation patients with drug-resistant focal epilepsy.Two-hundred fifteen stereotactic implantations multilead intracerebral electrodes were performed 211 (4 explored twice), who showed variable patterns localizing incoherence among electrical (interictal/ictal scalp electroencephalography), clinical (ictal semeiology), anatomic (magnetic resonance imaging [MRI])...
Study Objectives:Arousal parasomnias are expressions of sleep/ wake state dissociations in which wakefulness and NREM sleep seem to coexist. We describe the results a neurophysiological (intracerebral EEG) investigation that captured an episode confusional arousal.
We present the results of a retrospective study on 10 patients operated for intractable epilepsy associated with nodular heterotopia as identified by high resolution MRI. Seven had unilateral heterotopia, one patient symmetric bilateral and two asymmetric heterotopia. By stereo-electroencephalogram (SEEG) (nine patients) interictal activity within nodules was similar in all cases, ictal never started from alone but overlying cortex or simultaneously cortex. Excellent outcomes (Engel class...
We investigated the role of temporal pole (TP) in 48 consecutive patients with drug-refractory lobe epilepsy (TLE). Chronic depth recordings TP cortex activity were used association video recording ictal symptoms during spontaneous seizures. In 23 cases (48%, group 1) was involved at onset seizure, before or concurrently hippocampus. remaining 25 (52%, 2) 16.4 ± 13.8 s after A past history febrile seizures found both groups, no statistical difference. Ictal did not differentiate from...
Summary: Purpose. Periventricular nodular heterotopia (PNH) is among the most common malformations of cortical development, and affected patients are frequently characterized by focal drug‐resistant epilepsy. Here we analyzed clinical, MRI, electrophysiologic findings in 54 PNH to reevaluate classification PNH, relate anatomic features epileptic outcome, ascertain contribution nodules onset discharges. Methods: The were followed up for a prolonged period at Epilepsy Center our Institute. In...
Summary Objective To assess the diagnostic yield of 7T magnetic resonance imaging ( MRI ) in detecting and characterizing structural lesions patients with intractable focal epilepsy unrevealing conventional (1.5 or 3T) . Methods We conducted an observational clinical study on 21 (17 adults 4 children) epilepsy, exhibiting electroencephalographic features consistent a single seizure‐onset zone SOZ Patients were enrolled at two tertiary surgery centers imaged 7T, including whole brain...
Radiofrequency thermocoagulation (RF-TC) of presumed epileptogenic lesions and/or structures has gained new popularity as a treatment option for drug-resistant focal epilepsy, mainly in patients with mesial temporal lobe epilepsy. The role this minimally invasive procedure more complex cases which may require intracranial electroencephalographic evaluation, not been fully assessed. This retrospective study reports on case series particularly epilepsy who underwent...
ABSTRACT Pre‐surgical and post‐surgical data were examined compared from 215 consecutive patients undergoing surgery for intractable epilepsy. Patients selected on the basis of a proven histopathological diagnosis type I focal cortical dysplasia (FCD I), alone or associated with other lesions. The divided into five sub‐groups: i) 66 isolated FCD I, ii) 76 hippocampal sclerosis, iii) 49 tumours, iv) 16 malformations development v) eight anoxic‐ischaemic inflammatory diseases. duration...
Sleep-related complex motor seizures are a common feature of nocturnal frontal lobe epilepsy. Nevertheless, recent studies also suggest that sleep-related hypermotor can originate in the insula. The present study describes electroclinical features eight drug-resistant epileptic patients with insular-opercular manifesting seizures.Patients underwent comprehensive presurgical evaluation, which included history, interictal electroencephalography (EEG), scalp video-EEG monitoring,...
ABSTRACT Focal cortical dysplasias (FCDs) are highly epileptogenic malformations associated with drug‐resistant epilepsy, susceptible to surgical treatment. Among the different types of FCD, type II includes two subgroups based on absence (IIa) or presence (IIb) balloon cells. The aim this retrospective study was investigate possible differences in electroclinical presentations and outcomes between 100 consecutive surgically treated patients FCDs. All underwent a comprehensive presurgical...
Summary Sleep has been shown to be a global phenomenon in which the presence of local processes both activation and deactivation are finely orchestrated. Dysfunctional independent action systems involved non‐rapid eye movement (NREM) sleep wakefulness is deemed at basis arousal parasomnias. We show, patient with confusional arousals, persistence hippocampal frontal associative cortices contrast awakening motor, cingulate, insular, amygdalar temporopolar cortices. The clinical features...
Summary Objective In one third of patients with a diagnosis pharmacoresistant focal epilepsy who are candidates for therapeutic surgery, cerebral areas responsible seizure generation can be defined exclusively invasive intracranial recordings. A correct presurgical identification the epileptogenic zone ( EZ ) electrodes has direct impact on postsurgical outcome. We aimed at identifying biomarkers based computer‐assisted inspection electroencephalography EEG ). Methods Computer‐driven...