A5014136564- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Neurogenetic and Muscular Disorders Research
- Neuroscience and Neuropharmacology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Amyotrophic Lateral Sclerosis Research
- Mitochondrial Function and Pathology
- Cancer Immunotherapy and Biomarkers
- Neurological diseases and metabolism
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- MRI in cancer diagnosis
- Nausea and vomiting management
- Cardiac Structural Anomalies and Repair
- Metabolism and Genetic Disorders
- Advanced Neuroimaging Techniques and Applications
- Congenital Anomalies and Fetal Surgery
- Intensive Care Unit Cognitive Disorders
- Muscle Physiology and Disorders
- Anesthesia and Pain Management
- Anesthesia and Neurotoxicity Research
- Ferroptosis and cancer prognosis
- Glycogen Storage Diseases and Myoclonus
- Pharmacological Effects and Toxicity Studies
- Brain Metastases and Treatment
St. Franziskus Hospital
2024
University of Freiburg
2017-2018
University Medical Center Freiburg
2017-2018
Universitätsklinikum Erlangen
2015-2017
Epilepsy Foundation
2017
Friedrich-Alexander-Universität Erlangen-Nürnberg
2013-2014
Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy.We report diagnoses made basis of resected specimens from 9523 patients who underwent epilepsy surgery in 36 centers 12 European countries over 25 years. Histopathological were determined through examination local hospitals (41%) or at German Neuropathology Reference Center Epilepsy Surgery (59%).The onset occurred before 18 years age 75.9%...
Progressive functional decline in the epilepsies is largely unexplained. We formed ENIGMA-Epilepsy consortium to understand factors that influence brain measures epilepsy, pooling data from 24 research centres 14 countries across Europe, North and South America, Asia, Australia. Structural were extracted MRI scans 2149 individuals with divided into four epilepsy subgroups including idiopathic generalized (n =367), mesial temporal lobe hippocampal sclerosis (MTLE; left, n = 415; right, 339),...
// Dieter Henrik Heiland 1, 4 , Gerrit Haaker Daniel Delev Bianca Mercas Waseem Masalha Sabrina Heynckes Annette Gäbelein Dietmar Pfeifer 2, Maria Stella Carro Astrid Weyerbrock Marco Prinz 3, 4, 5 and Oliver Schnell 1 Department of Neurosurgery, Medical Center - University Freiburg, Baden-Württemberg, Germany 2 Hematology, Oncology Stem Cell Transplantation, 3 Institute Neuropathology, Faculty Medicine, BIOSS Centre for Biological Signalling Studies, Correspondence to: Heiland,...
Progressive cardiomyopathy (CMP) is one main cause of death in DMD. This cross-sectional assessment different cardiac diagnostic procedures focusses on preterm diagnosis dysfunction.39 male DMD patients aged 6-20 years were included. 6 still ambulatory, 21 received corticosteroid therapy.All investigated by ECG, Holter ECG and heart rate variability (HRV), B-type natriuretic peptide (BNP), echocardiography (TTE), tissue Doppler Imaging (TD) magnetic resonance imaging (MRI) with Late...
The biology of recurrent glioblastoma multiforme (GBM) is a dynamic process influenced by selection pressure induced different antitumoural therapies. poor clinical outcome tumours in the stage necessitates development effective therapeutic strategies. Checkpoint-inhibition (PD1/PD-L1 Inhibition) hallmark immunotherapy being investigated ongoing trials. purpose this study was to analyse PD-L1 expression de-novo and explore associated genetic alterations traits. We show that reduced GBM...
Abstract In the past, changes of Apparent Diffusion Coefficient in glioblastoma multiforme have been shown to be related specific genes and described as being associated with survival. The purpose this study was investigate diffusion imaging parameters combination genome-wide expression data order obtain a comprehensive characterisation transcriptomic indicated by parameters. Diffusion-weighted imaging, molecular clinical were collected prospectively 21 patients. Before surgery, MRI metrics...
Abstract Background Postoperative delirium (POD) is a severe perioperative complication that may increase mortality and length-of-stay in older patients. Moreover, POD major economic burden to any healthcare system. An altered expression of Acetylcholine- Butyrylcholinesterases (AChE, BuChE) due an unbalanced neuroinflammatory response trauma or operative stimulus has been reported play essential role the development POD. We investigated if measurement cholinesterases (ChEs) can help...
Pompe disease (PD), a lysosomal storage as well neuromuscular disorder, is rare marked by progressive muscle weakness. Enzyme replacement therapy (ERT) in recent years allowed longer survival but brought new problems to the treatment of PD with increasing affection musculoskeletal system, particularly significantly higher prevalence scoliosis. The present paper deals orthopedic patients and first describe surgical scoliosis patients.The eight from consultation for disorders are...